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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Shank3 (Rattus norvegicus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000165MAPKKK cascadeISO
GO:0001838embryonic epithelial tube formationIEA
GO:0001838embryonic epithelial tube formationISO
GO:0007416synapse assemblyISO
GO:0021773striatal medium spiny neuron differentiationISO
GO:0021773striatal medium spiny neuron differentiationISS
GO:0035176social behaviorISO
GO:0035176social behaviorISS
GO:0035641locomotory exploration behaviorISO
GO:0035641locomotory exploration behaviorISS
GO:0045794negative regulation of cell volumeISO
GO:0045794negative regulation of cell volumeISS
GO:0048170positive regulation of long-term neuronal synaptic plasticityISS
GO:0048854brain morphogenesisISO
GO:0048854brain morphogenesisISS
GO:0051259protein oligomerizationIDA
GO:0051835positive regulation of synapse structural plasticityISS
GO:0051968positive regulation of synaptic transmission, glutamatergicISO
GO:0051968positive regulation of synaptic transmission, glutamatergicISS
GO:0060997dendritic spine morphogenesisISO
GO:0060997dendritic spine morphogenesisISS
GO:0071625vocalization behaviorISS
GO:0097107postsynaptic density assemblyISO
GO:0097107postsynaptic density assemblyISS
GO:2000463positive regulation of excitatory postsynaptic membrane potentialISO
GO:2000463positive regulation of excitatory postsynaptic membrane potentialISS
GO:2000821regulation of grooming behaviorISO
GO:2000822regulation of behavioral fear responseISO
GO:2000822regulation of behavioral fear responseISS
GO:2000969positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISO
GO:2000969positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISS
cellular_component
GO:0005737cytoplasmIEA
GO:0005886plasma membraneISO
GO:0005886plasma membraneISS
GO:0014069postsynaptic densityIDA
GO:0030054cell junctionIEA
GO:0044309neuron spineISO
GO:0044309neuron spineISS
GO:0045202synapseIDA
GO:0045211postsynaptic membraneIEA
molecular_function
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0008022protein C-terminus bindingISO
GO:0008270zinc ion bindingIDA
GO:0017124SH3 domain bindingIPI
GO:0030160GKAP/Homer scaffold activityIDA
GO:0035255ionotropic glutamate receptor bindingISO
GO:0035255ionotropic glutamate receptor bindingISS
GO:0043621protein self-associationIDA
GO:0097110scaffold protein bindingIPI
GO:0097110scaffold protein bindingISO

Protein-protein interaction details for Shank3 (Rattus norvegicus)
(Information is obtained from BioGRID)
Interacting proteinExperimentTypePubMed ID
Homer1Two-hybridphysical10433269
Homer1Reconstituted Complexphysical10433269
Dlgap3Two-hybridphysical10433269
Dlgap3Reconstituted Complexphysical10433269
Dlgap3Reconstituted Complexphysical10433269
Grm5Reconstituted Complexphysical10433269
Dlgap1Two-hybridphysical10433268