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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NOD2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0002218 activation of innate immune response TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002227 innate immune response in mucosa IEA GO:0002253 activation of immune response IEA GO:0002367 cytokine production involved in immune response IMP GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IEA GO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS GO:0002710 negative regulation of T cell mediated immunity IEA GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0002830 positive regulation of type 2 immune response IMP GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA GO:0006952 defense response TAS GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IEA GO:0007254 JNK cascade TAS GO:0008063 Toll signaling pathway TAS GO:0009595 detection of biotic stimulus TAS GO:0016045 detection of bacterium IDA GO:0031398 positive regulation of protein ubiquitination IEA GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA GO:0032495 response to muramyl dipeptide IDA GO:0032495 response to muramyl dipeptide IEA GO:0032496 response to lipopolysaccharide IEA GO:0032498 detection of muramyl dipeptide IDA GO:0032689 negative regulation of interferon-gamma production IEA GO:0032695 negative regulation of interleukin-12 production IEA GO:0032701 negative regulation of interleukin-18 production IEA GO:0032703 negative regulation of interleukin-2 production IEA GO:0032720 negative regulation of tumor necrosis factor production IEA GO:0032731 positive regulation of interleukin-1 beta production IMP GO:0032733 positive regulation of interleukin-10 production IEA GO:0032733 positive regulation of interleukin-10 production ISS GO:0032735 positive regulation of interleukin-12 production IEA GO:0032740 positive regulation of interleukin-17 production IMP GO:0032755 positive regulation of interleukin-6 production IDA GO:0032755 positive regulation of interleukin-6 production IEA GO:0032760 positive regulation of tumor necrosis factor production IDA GO:0032760 positive regulation of tumor necrosis factor production IEA GO:0032760 positive regulation of tumor necrosis factor production IMP GO:0032874 positive regulation of stress-activated MAPK cascade IDA GO:0032874 positive regulation of stress-activated MAPK cascade IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0035419 activation of MAPK activity involved in innate immune response IEA GO:0035419 activation of MAPK activity involved in innate immune response ISS GO:0035556 intracellular signal transduction IDA GO:0042742 defense response to bacterium IDA GO:0042981 regulation of apoptosis IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IDA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEA GO:0043330 response to exogenous dsRNA IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS GO:0044130 negative regulation of growth of symbiont in host IEA GO:0045087 innate immune response NAS GO:0045087 innate immune response TAS GO:0045089 positive regulation of innate immune response IEA GO:0045747 positive regulation of Notch signaling pathway IEA GO:0045747 positive regulation of Notch signaling pathway ISS GO:0046330 positive regulation of JNK cascade IDA GO:0046330 positive regulation of JNK cascade IEA GO:0046645 positive regulation of gamma-delta T cell activation ISS GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0050679 positive regulation of epithelial cell proliferation ISS GO:0050718 positive regulation of interleukin-1 beta secretion IDA GO:0050727 regulation of inflammatory response IC GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050766 positive regulation of phagocytosis IEA GO:0050830 defense response to Gram-positive bacterium IEA GO:0050871 positive regulation of B cell activation IDA GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051092 positive regulation of NF-kappaB transcription factor activity IEA GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0051259 protein oligomerization TAS GO:0051353 positive regulation of oxidoreductase activity ISS GO:0051403 stress-activated MAPK cascade TAS GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IEA GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA GO:0071224 cellular response to peptidoglycan IEA GO:0071608 macrophage inflammatory protein-1 alpha production IEA GO:0090022 regulation of neutrophil chemotaxis IEA GO:2000110 negative regulation of macrophage apoptosis IEA GO:2000110 negative regulation of macrophage apoptosis ISS GO:2000363 positive regulation of prostaglandin-E synthase activity IEA GO:2000363 positive regulation of prostaglandin-E synthase activity ISS cellular_component GO:0005622 intracellular IEA GO:0005737 cytoplasm TAS GO:0005829 cytosol IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0008180 signalosome IDA GO:0009986 cell surface IDA GO:0031982 vesicle IDA molecular_function GO:0000166 nucleotide binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0019899 enzyme binding IPI GO:0019901 protein kinase binding IPI GO:0032500 muramyl dipeptide binding IDA GO:0042834 peptidoglycan binding IDA GO:0050700 CARD domain binding IPI

Protein-protein interaction details for NOD2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NLRC4 Affinity Capture-Western physical 15107016 CASP1 Affinity Capture-Western physical 15107016 NLRC4 Affinity Capture-Western physical 11472070 RIPK2 Affinity Capture-Western physical 11087742 RIPK2 Affinity Capture-Western physical 19592251 RIPK2 Affinity Capture-Western physical 15620648 RIPK2 Affinity Capture-Western physical 15620648 RIPK2 Affinity Capture-Western physical 21123652 RIPK2 Affinity Capture-Western physical 21123652