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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIAH1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006508 proteolysis TAS GO:0006915 apoptosis TAS GO:0007049 cell cycle IEA GO:0007275 multicellular organismal development IEA GO:0007283 spermatogenesis IEA GO:0007399 nervous system development TAS GO:0007411 axon guidance TAS GO:0009653 anatomical structure morphogenesis TAS GO:0030154 cell differentiation IEA GO:0030163 protein catabolic process IDA GO:0031648 protein destabilization IEA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISS GO:0043065 positive regulation of apoptosis IDA GO:0043161 proteasomal ubiquitin-dependent protein catabolic process ISS GO:0051402 neuron apoptosis ISS cellular_component GO:0005624 membrane fraction IEA GO:0005634 nucleus ISS GO:0005737 cytoplasm IEA GO:0005769 early endosome IEA GO:0005829 cytosol TAS GO:0030877 beta-catenin destruction complex IDA molecular_function GO:0004842 ubiquitin-protein ligase activity ISS GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0008270 zinc ion binding IDA GO:0008270 zinc ion binding ISS GO:0016874 ligase activity IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for SIAH1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID KIF22 Two-hybrid physical 11146551 PEG10 Two-hybrid physical 12810624 CACYBP Two-hybrid physical 11389839 AFF4 Two-hybrid physical 16189514 KHDRBS3 Two-hybrid physical 16189514 RBBP8 Reconstituted Complex physical 14654780 RBBP8 Affinity Capture-Western physical 14654780 RBBP8 Two-hybrid physical 14654780 KHDRBS3 Two-hybrid physical 15163637 KHDRBS3 Reconstituted Complex physical 15163637 PEG10 Reconstituted Complex physical 12810624 DAB1 Affinity Capture-Western physical 12646221 DAB1 Affinity Capture-Western physical 12646221 DAB1 Reconstituted Complex physical 12646221 DAB1 Reconstituted Complex physical 12646221 DAB1 Two-hybrid physical 12646221 APC Reconstituted Complex physical 11389840 APC Affinity Capture-Western physical 11389840 PEG3 Affinity Capture-Western physical 10681424 PEG3 Two-hybrid physical 10681424 CACYBP Reconstituted Complex physical 11389839 CACYBP Affinity Capture-Western physical 11389839 UBE2E3 Two-hybrid physical 11389839 UBE2D1 Two-hybrid physical 11389839 TBL1X Affinity Capture-Western physical 11389839 SYP Reconstituted Complex physical 11786535 VAV1 Two-hybrid physical 10207103 BAG1 Reconstituted Complex physical 9582267 SIAH1 Reconstituted Complex physical 9582267 BAG1 Affinity Capture-Western physical 9582267 BAG1 Two-hybrid physical 9582267 BAG1 Reconstituted Complex physical 9582267 POU2AF1 Two-hybrid physical 11483517 POU2AF1 Affinity Capture-Western physical 11483517 POU2AF1 Reconstituted Complex physical 11483517 POU2AF1 Phenotypic Suppression genetic 11483517 KIF22 Reconstituted Complex physical 11146551 KIF22 Reconstituted Complex physical 11146551 KIF22 Affinity Capture-Western physical 11146551 NUMB Two-hybrid physical 11752454 NUMB Reconstituted Complex physical 11752454 NUMB Reconstituted Complex physical 11752454 NUMB Affinity Capture-Western physical 11752454 SIAH1 Co-purification physical 11752454 DCC Reconstituted Complex physical 9858595 HIF1AN Affinity Capture-Western physical 18280659 TRIB3 Two-hybrid physical 18276110 TRIB3 Affinity Capture-Western physical 18276110 TRIB3 Affinity Capture-Western physical 18276110 PIAS1 Two-hybrid physical 17533377 PIAS2 Two-hybrid physical 17533377 UBE2I Two-hybrid physical 17533377 PIAS1 Reconstituted Complex physical 17533377 PIAS3 Reconstituted Complex physical 17533377 SIAH1 Biochemical Activity physical 17420721 SIAH1 Affinity Capture-Western physical 17420721 UBE2D2 Two-hybrid physical 19690564 UBE2D3 Two-hybrid physical 19690564 UBE2D4 Two-hybrid physical 19690564 UBE2N Two-hybrid physical 19549727 UBE2K Two-hybrid physical 19549727 UBE2D1 Two-hybrid physical 19549727 UBE2D2 Two-hybrid physical 19549727 UBE2D3 Two-hybrid physical 19549727 UBE2V2 Two-hybrid physical 19549727 PKD1 Two-hybrid physical 15284290 PKD1 Affinity Capture-Western physical 15284290 SNCAIP Reconstituted Complex physical 15064394 SNCAIP Affinity Capture-Western physical 15064394 SNCAIP Affinity Capture-Western physical 15064394 SNCAIP Biochemical Activity physical 15064394 SNCAIP Affinity Capture-Western physical 14506261 SNCAIP Reconstituted Complex physical 14506261 SNCAIP Reconstituted Complex physical 14506261 UBC Affinity Capture-Western physical 14506261 RUNX1 Affinity Capture-Western physical 18073335 RLIM Affinity Capture-Western physical 18073335 UBE2L6 Reconstituted Complex physical 18073335 RUNX1 Affinity Capture-Western physical 18073335 PML Affinity Capture-Western physical 18073335 RARA Affinity Capture-Western physical 18073335 PHC2 Affinity Capture-Western physical 20471960 PHC2 Reconstituted Complex physical 20471960 UBE2E2 Reconstituted Complex physical 18073335 UBE2E2 Affinity Capture-Western physical 18073335 PLCE1 Affinity Capture-Western physical 17998205 EEF1D Reconstituted Complex physical 21633900 EEF1D Affinity Capture-Western physical 21633900 HIPK2 Two-hybrid physical 19043406 HIPK2 Reconstituted Complex physical 19043406 HIPK2 Affinity Capture-Western physical 19043406 HIPK2 Reconstituted Complex physical 19043406 HIPK2 Affinity Capture-Western physical 19043406 HERPUD1 Affinity Capture-Western physical 20604806 HERPUD1 Affinity Capture-Western physical 20604806 CTNNB1 Biochemical Activity physical 20181957 CACYBP Biochemical Activity physical 20181957 XIAP Affinity Capture-Western physical 21185211 XIAP Affinity Capture-Western physical 21185211 SEPT4 Affinity Capture-Western physical 21185211 ATXN7 Two-hybrid physical 21078624 SNCA Reconstituted Complex physical 18065497 SNCA Affinity Capture-Western physical 18065497 UBE2E2 Affinity Capture-Western physical 18065497 SNCA Biochemical Activity physical 18070888 SNCA Affinity Capture-Western physical 18070888 SNCA Reconstituted Complex physical 19224863 SNCA Affinity Capture-Western physical 19224863 SNCA Biochemical Activity physical 19224863 UBC Affinity Capture-Western physical 19224863 SNCA Affinity Capture-Western physical 19224863 SIAH1 Biochemical Activity physical 19224863 UBC Reconstituted Complex physical 19224863 PSMC5 Affinity Capture-Western physical 20479273 PSMC6 Affinity Capture-Western physical 20479273 TERF2 Reconstituted Complex physical 21057505 TERF2 Biochemical Activity physical 21057505 FLT3 Reconstituted Complex physical 20508617 FLT3 Affinity Capture-Western physical 20508617 PARD3 Affinity Capture-Western physical 21109632 UBC Affinity Capture-Western physical 15273720