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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for BMP2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0001501 skeletal system development TAS GO:0001649 osteoblast differentiation IDA GO:0001658 branching involved in ureteric bud morphogenesis IEA GO:0001666 response to hypoxia IEA GO:0001701 in utero embryonic development IEA GO:0001837 epithelial to mesenchymal transition IDA GO:0001934 positive regulation of protein phosphorylation IDA GO:0001938 positive regulation of endothelial cell proliferation IDA GO:0003130 BMP signaling pathway involved in heart induction IDA GO:0003181 atrioventricular valve morphogenesis IEA GO:0003203 endocardial cushion morphogenesis IEA GO:0006355 regulation of transcription, DNA-dependent IDA GO:0006954 inflammatory response IEA GO:0007219 Notch signaling pathway IEA GO:0007267 cell-cell signaling TAS GO:0008285 negative regulation of cell proliferation IDA GO:0009612 response to mechanical stimulus IEA GO:0009790 embryo development IEA GO:0009887 organ morphogenesis IEA GO:0010628 positive regulation of gene expression IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP GO:0010922 positive regulation of phosphatase activity IDA GO:0021537 telencephalon development IDA GO:0021978 telencephalon regionalization IEA GO:0030335 positive regulation of cell migration IEA GO:0030501 positive regulation of bone mineralization IDA GO:0030509 BMP signaling pathway IDA GO:0030509 BMP signaling pathway IMP GO:0030509 BMP signaling pathway TAS GO:0031648 protein destabilization IEA GO:0032526 response to retinoic acid IEA GO:0033690 positive regulation of osteoblast proliferation IEA GO:0035051 cardiac cell differentiation IDA GO:0035051 cardiac cell differentiation IMP GO:0035054 embryonic heart tube anterior/posterior pattern specification IEA GO:0035630 bone mineralization involved in bone maturation IDA GO:0040007 growth IEA GO:0042475 odontogenesis of dentine-containing tooth IEA GO:0042482 positive regulation of odontogenesis IEA GO:0042698 ovulation cycle IEA GO:0043065 positive regulation of apoptosis IDA GO:0045165 cell fate commitment IEA GO:0045666 positive regulation of neuron differentiation IEA GO:0045669 positive regulation of osteoblast differentiation IDA GO:0045778 positive regulation of ossification IDA GO:0045786 negative regulation of cell cycle IDA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0048711 positive regulation of astrocyte differentiation IEA GO:0048762 mesenchymal cell differentiation IDA GO:0050769 positive regulation of neurogenesis IEA GO:0055008 cardiac muscle tissue morphogenesis IEA GO:0060039 pericardium development IEA GO:0060128 corticotropin hormone secreting cell differentiation IEA GO:0060129 thyroid-stimulating hormone-secreting cell differentiation IEA GO:0060317 cardiac epithelial to mesenchymal transition IDA GO:0060389 pathway-restricted SMAD protein phosphorylation IDA GO:0060395 SMAD protein signal transduction IDA GO:0060804 positive regulation of Wnt receptor signaling pathway by BMP signaling pathway IEA GO:0061036 positive regulation of cartilage development IDA GO:0071363 cellular response to growth factor stimulus IEA GO:0071407 cellular response to organic cyclic compound IEA cellular_component GO:0005576 extracellular region TAS GO:0005615 extracellular space IEA GO:0005737 cytoplasm IEA GO:0031988 membrane-bounded vesicle IEA GO:0043234 protein complex IEA molecular_function GO:0004675 transmembrane receptor protein serine/threonine kinase activity TAS GO:0004745 retinol dehydrogenase activity IEA GO:0005102 receptor binding TAS GO:0005125 cytokine activity IEA GO:0005515 protein binding IPI GO:0008083 growth factor activity IEA GO:0016362 activin receptor activity, type II TAS GO:0019211 phosphatase activator activity IDA GO:0019904 protein domain specific binding IEA GO:0042803 protein homodimerization activity IEA GO:0046332 SMAD binding IDA GO:0046982 protein heterodimerization activity IDA GO:0070700 BMP receptor binding IDA

Protein-protein interaction details for BMP2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BMPR1A Co-crystal Structure physical 11263668 BMPR2 Affinity Capture-Western physical 7791754 SOSTDC1 Affinity Capture-Western physical 15020244 COL2A1 Affinity Capture-Western physical 10085302 COL2A1 Reconstituted Complex physical 10085302 COL2A1 Affinity Capture-Western physical 10085302 ENG Affinity Capture-Western physical 9872992 BMPR1A Reconstituted Complex physical 10692589 BMPR1A Reconstituted Complex physical 10880444 BMPR2 Reconstituted Complex physical 10880444 ACTR2 Reconstituted Complex physical 10880444 MGP Affinity Capture-Western physical 11741887 BMPR1A Reconstituted Complex physical 10712517 BMPR1B Reconstituted Complex physical 10712517 BMPR2 Reconstituted Complex physical 10712517