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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SOX2 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001649osteoblast differentiationIDA
GO:0001654eye developmentIEP
GO:0001714endodermal cell fate specificationIDA
GO:0006325chromatin organizationNAS
GO:0006351transcription, DNA-dependentIDA
GO:0006351transcription, DNA-dependentNAS
GO:0006355regulation of transcription, DNA-dependentIDA
GO:0006355regulation of transcription, DNA-dependentNAS
GO:0007050cell cycle arrestIDA
GO:0007275multicellular organismal developmentIEA
GO:0009611response to woundingIEP
GO:0010468regulation of gene expressionIMP
GO:0021781glial cell fate commitmentNAS
GO:0021983pituitary gland developmentIEP
GO:0030900forebrain developmentIEP
GO:0035019somatic stem cell maintenanceIDA
GO:0035019somatic stem cell maintenanceIMP
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0043410positive regulation of MAPKKK cascadeIDA
GO:0045665negative regulation of neuron differentiationISS
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048839inner ear developmentIEP
GO:0050680negative regulation of epithelial cell proliferationIDA
GO:0070848response to growth factor stimulusIDA
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayIDA
cellular_component
GO:0005634nucleusIC
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005667transcription factor complexTAS
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
molecular_function
GO:0003677DNA bindingIDA
GO:0003677DNA bindingNAS
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0005515protein bindingIPI
GO:0035198miRNA bindingIDA
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA

Protein-protein interaction details for SOX2 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
POU5F1Reconstituted Complexphysical12923055
PAX6Affinity Capture-Westernphysical12710953
PAX6Affinity Capture-Westernphysical12710953
ALX4Two-hybridphysical20211142
MECP2Affinity Capture-Westernphysical20368621
MECP2Affinity Capture-Westernphysical20368621
ZNF281Affinity Capture-Westernphysical18757296
XPO1Reconstituted Complexphysical19591226