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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SOX9 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001501 skeletal system development IMP GO:0001502 cartilage condensation ISS GO:0001708 cell fate specification ISS GO:0001837 epithelial to mesenchymal transition ISS GO:0001894 tissue homeostasis ISS GO:0001934 positive regulation of protein phosphorylation ISS GO:0001942 hair follicle development ISS GO:0002053 positive regulation of mesenchymal cell proliferation ISS GO:0002683 negative regulation of immune system process ISS GO:0003170 heart valve development ISS GO:0003179 heart valve morphogenesis ISS GO:0003188 heart valve formation IEA GO:0003203 endocardial cushion morphogenesis ISS GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IMP GO:0003415 chondrocyte hypertrophy ISS GO:0006334 nucleosome assembly IDA GO:0006338 chromatin remodeling IDA GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent IMP GO:0006461 protein complex assembly IDA GO:0006468 protein phosphorylation ISS GO:0007165 signal transduction ISS GO:0007173 epidermal growth factor receptor signaling pathway ISS GO:0007283 spermatogenesis ISS GO:0008284 positive regulation of cell proliferation IMP GO:0008584 male gonad development IEP GO:0008584 male gonad development IMP GO:0010564 regulation of cell cycle process IMP GO:0010634 positive regulation of epithelial cell migration IMP GO:0014032 neural crest cell development IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade ISS GO:0019100 male germ-line sex determination ISS GO:0019933 cAMP-mediated signaling IDA GO:0030155 regulation of cell adhesion IEA GO:0030198 extracellular matrix organization IEA GO:0030279 negative regulation of ossification ISS GO:0030502 negative regulation of bone mineralization IEA GO:0030850 prostate gland development IEP GO:0030858 positive regulation of epithelial cell differentiation ISS GO:0030916 otic vesicle formation ISS GO:0031018 endocrine pancreas development IEA GO:0032331 negative regulation of chondrocyte differentiation ISS GO:0032332 positive regulation of chondrocyte differentiation IDA GO:0032332 positive regulation of chondrocyte differentiation IMP GO:0035019 somatic stem cell maintenance ISS GO:0035622 intrahepatic bile duct development IEA GO:0042127 regulation of cell proliferation ISS GO:0042981 regulation of apoptosis ISS GO:0043066 negative regulation of apoptosis IMP GO:0043066 negative regulation of apoptosis ISS GO:0045595 regulation of cell differentiation IEA GO:0045662 negative regulation of myoblast differentiation ISS GO:0045732 positive regulation of protein catabolic process IEA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0046533 negative regulation of photoreceptor cell differentiation ISS GO:0048709 oligodendrocyte differentiation IEA GO:0050679 positive regulation of epithelial cell proliferation IEP GO:0050679 positive regulation of epithelial cell proliferation ISS GO:0050680 negative regulation of epithelial cell proliferation ISS GO:0051216 cartilage development ISS GO:0060008 Sertoli cell differentiation ISS GO:0060009 Sertoli cell development IEA GO:0060018 astrocyte fate commitment IEA GO:0060041 retina development in camera-type eye ISS GO:0060221 retinal rod cell differentiation ISS GO:0060350 endochondral bone morphogenesis IEA GO:0060512 prostate gland morphogenesis IEA GO:0060517 epithelial cell proliferation involved in prostatic bud elongation ISS GO:0060729 intestinal epithelial structure maintenance ISS GO:0060784 regulation of cell proliferation involved in tissue homeostasis ISS GO:0061036 positive regulation of cartilage development IDA GO:0061138 morphogenesis of a branching epithelium ISS GO:0070168 negative regulation of biomineral tissue development ISS GO:0070371 ERK1 and ERK2 cascade ISS GO:0071260 cellular response to mechanical stimulus ISS GO:0071300 cellular response to retinoic acid IEP GO:0071347 cellular response to interleukin-1 IEP GO:0071364 cellular response to epidermal growth factor stimulus ISS GO:0071504 cellular response to heparin ISS GO:0071560 cellular response to transforming growth factor beta stimulus IDA GO:0072034 renal vesicle induction ISS GO:0072197 ureter morphogenesis IEA GO:0072289 metanephric nephron tubule formation ISS GO:0090090 negative regulation of canonical Wnt receptor signaling pathway ISS GO:0090103 cochlea morphogenesis ISS GO:0090184 positive regulation of kidney development ISS GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISS GO:2000020 positive regulation of male gonad development IDA GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IEA GO:2000741 positive regulation of mesenchymal stem cell differentiation IDA cellular_component GO:0005634 nucleus IDA GO:0005730 nucleolus IDA GO:0016585 chromatin remodeling complex IDA GO:0043234 protein complex IDA molecular_function GO:0001046 core promoter sequence-specific DNA binding IDA GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA GO:0001158 enhancer sequence-specific DNA binding ISS GO:0003677 DNA binding IEA GO:0003682 chromatin binding IDA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IMP GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IDA GO:0004672 protein kinase activity ISS GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IEA GO:0034236 protein kinase A catalytic subunit binding IPI GO:0035326 enhancer binding IDA GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for SOX9 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NR5A1 Two-hybrid physical 9774680 MAF Two-hybrid physical 12381733 MAF Affinity Capture-Western physical 12381733 MAF Affinity Capture-Western physical 12381733 MAF Reconstituted Complex physical 12381733 MAF Reconstituted Complex physical 12381733 NR5A1 Reconstituted Complex physical 9774680 NR5A1 Affinity Capture-Western physical 9774680 MED12 Two-hybrid physical 12136106 MED12 Reconstituted Complex physical 12136106 MED12 Reconstituted Complex physical 12136106 MED12 Affinity Capture-Western physical 12136106 HSPA1A Affinity Capture-Western physical 11356186 EP300 Affinity Capture-Western physical 19828133 EP300 Affinity Capture-Western physical 19828133 SCXA Affinity Capture-Western physical 19828133 EP300 Affinity Capture-Western physical 12732631 CREB3L4 Reconstituted Complex physical 12732631 SMAD2 Affinity Capture-Western physical 15623506 SMAD3 Affinity Capture-Western physical 15623506 EP300 Affinity Capture-Western physical 15623506 RUNX2 FRET physical 20593410