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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Lrrk2 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000165MAPKKK cascadeISO
GO:0000186activation of MAPKK activityISO
GO:0001934positive regulation of protein phosphorylationISO
GO:0006468protein phosphorylationISA
GO:0006979response to oxidative stressISO
GO:0007264small GTPase mediated signal transductionIEA
GO:0007406negative regulation of neuroblast proliferationISO
GO:0007528neuromuscular junction developmentISO
GO:0008340determination of adult lifespanISO
GO:0010508positive regulation of autophagyIMP
GO:0010942positive regulation of cell deathISO
GO:0014043negative regulation of neuron maturationISO
GO:0016310phosphorylationIEA
GO:0018105peptidyl-serine phosphorylationISO
GO:0021772olfactory bulb developmentISO
GO:0022028tangential migration from the subventricular zone to the olfactory bulbISO
GO:0031398positive regulation of protein ubiquitinationISO
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIMP
GO:0035564regulation of kidney sizeIMP
GO:0035640exploration behaviorISO
GO:0040012regulation of locomotionISO
GO:0042391regulation of membrane potentialISO
GO:0043068positive regulation of programmed cell deathISO
GO:0043547positive regulation of GTPase activityISO
GO:0046777protein autophosphorylationISA
GO:0046777protein autophosphorylationISO
GO:0048312intracellular distribution of mitochondriaISO
GO:0060161positive regulation of dopamine receptor signaling pathwayISO
GO:0061002negative regulation of dendritic spine morphogenesisISO
GO:0070997neuron deathISO
GO:2000173negative regulation of branching morphogenesis of a nerveISO
cellular_component
GO:0005622intracellularISO
GO:0005624membrane fractionISO
GO:0005737cytoplasmISO
GO:0005792microsomeISO
GO:0005802trans-Golgi networkIDA
GO:0005886plasma membraneIDA
GO:0008021synaptic vesicleIDA
GO:0019717synaptosomeISO
GO:0030424axonISO
GO:0030425dendriteISO
GO:0032473external side of mitochondrial outer membraneISO
GO:0045121membrane raftIDA
molecular_function
GO:0000166nucleotide bindingIEA
GO:0004672protein kinase activityISO
GO:0004674protein serine/threonine kinase activityISO
GO:0004708MAP kinase kinase activityISO
GO:0005096GTPase activator activityISO
GO:0005488bindingIEA
GO:0005524ATP bindingIEA
GO:0005525GTP bindingISA
GO:0005525GTP bindingISO
GO:0015631tubulin bindingISO
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsIEA
GO:0034211GTP-dependent protein kinase activityISA
GO:0034211GTP-dependent protein kinase activityISO
GO:0042803protein homodimerization activityISO

Protein-protein interaction details for Lrrk2 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Stub1Affinity Capture-Westernphysical19196961