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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TCF7L2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0001568 blood vessel development IMP GO:0006351 transcription, DNA-dependent IDA GO:0006357 regulation of transcription from RNA polymerase II promoter IDA GO:0006916 anti-apoptosis IDA GO:0007050 cell cycle arrest IMP GO:0007420 brain development IBA GO:0008283 cell proliferation IMP GO:0009749 response to glucose stimulus ISS GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process IMP GO:0022008 neurogenesis IBA GO:0031016 pancreas development TAS GO:0032024 positive regulation of insulin secretion IDA GO:0032024 positive regulation of insulin secretion IMP GO:0032092 positive regulation of protein binding IDA GO:0032350 regulation of hormone metabolic process IDA GO:0042593 glucose homeostasis IDA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0043570 maintenance of DNA repeat elements IMP GO:0044334 canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP GO:0045444 fat cell differentiation IDA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0046827 positive regulation of protein export from nucleus IMP GO:0048625 myoblast cell fate commitment IDA GO:0048660 regulation of smooth muscle cell proliferation IMP GO:0048699 generation of neurons IBA GO:0051897 positive regulation of protein kinase B signaling cascade IMP GO:0060070 canonical Wnt receptor signaling pathway IC GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IMP cellular_component GO:0005634 nucleus IDA GO:0005654 nucleoplasm IDA GO:0005667 transcription factor complex IBA GO:0016605 PML body IEA GO:0032993 protein-DNA complex IDA GO:0070369 beta-catenin-TCF7L2 complex IDA molecular_function GO:0003677 DNA binding IEA GO:0003682 chromatin binding IBA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IDA GO:0008013 beta-catenin binding IPI GO:0008134 transcription factor binding IPI GO:0019901 protein kinase binding IPI GO:0035257 nuclear hormone receptor binding IPI GO:0043565 sequence-specific DNA binding IDA GO:0043565 sequence-specific DNA binding IMP GO:0044212 transcription regulatory region DNA binding IDA GO:0045295 gamma-catenin binding IPI GO:0070016 armadillo repeat domain binding IPI

Protein-protein interaction details for TCF7L2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CTNNB1 Affinity Capture-Western physical 12861022 NLK Affinity Capture-Western physical 12556497 JUP Reconstituted Complex physical 11711551 PSEN1 Affinity Capture-Western physical 11504726 DAZAP2 Two-hybrid physical 19304756 DAZAP2 Affinity Capture-Western physical 19304756 DAZAP2 Reconstituted Complex physical 19304756 CTNNB1 Affinity Capture-Western physical 19304756 DAZAP2 Affinity Capture-Western physical 19304756 CTBP1 Reconstituted Complex physical 12711682 CTNNB1 Phenotypic Suppression genetic 12861022 CTNNB1 Phenotypic Enhancement genetic 12861022 NR5A1 Phenotypic Enhancement genetic 12861022 CEBPA Phenotypic Enhancement genetic 12861022 EP300 Phenotypic Enhancement genetic 12861022