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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TERT (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000723 telomere maintenance TAS GO:0006278 RNA-dependent DNA replication IEA GO:0006916 anti-apoptosis IMP GO:0007004 telomere maintenance via telomerase IMP GO:0007004 telomere maintenance via telomerase TAS GO:0022616 DNA strand elongation IDA GO:0032203 telomere formation via telomerase IDA GO:0090399 replicative senescence IMP cellular_component GO:0000781 chromosome, telomeric region IC GO:0000783 nuclear telomere cap complex IC GO:0005634 nucleus IEA GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005694 chromosome IEA GO:0005697 telomerase holoenzyme complex IDA GO:0005730 nucleolus IEA GO:0005737 cytoplasm IEA GO:0016605 PML body IDA molecular_function GO:0003677 DNA binding IEA GO:0003720 telomerase activity IDA GO:0003721 telomeric template RNA reverse transcriptase activity IDA GO:0003721 telomeric template RNA reverse transcriptase activity TAS GO:0003723 RNA binding IEA GO:0003964 RNA-directed DNA polymerase activity IEA GO:0005515 protein binding IPI GO:0016740 transferase activity IEA GO:0016779 nucleotidyltransferase activity IEA GO:0042162 telomeric DNA binding TAS GO:0042803 protein homodimerization activity IDA GO:0046872 metal ion binding IEA GO:0070034 telomeric RNA binding IDA

Protein-protein interaction details for TERT (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NCL Affinity Capture-Western physical 15371412 NCL Reconstituted Complex physical 15371412 MCRS1 Affinity Capture-Western physical 15044100 MCRS1 Reconstituted Complex physical 15044100 SMG6 Reconstituted Complex physical 12699629 SMG5 Reconstituted Complex physical 12699629 HSP90AA1 Affinity Capture-Western physical 12586360 XRCC5 Affinity Capture-Western physical 12377759 XRCC6 Affinity Capture-Western physical 12377759 XRCC5 Reconstituted Complex physical 12377759 XRCC6 Reconstituted Complex physical 12377759 TEP1 Affinity Capture-Western physical 11029039 RELA Affinity Capture-Western physical 12517770 AKT1 Affinity Capture-Western physical 15843522 MTOR Affinity Capture-Western physical 15843522 HSP90AA1 Affinity Capture-Western physical 15843522 RPS6KB1 Affinity Capture-Western physical 15843522 PINX1 Affinity Capture-Western physical 11701125 PINX1 Reconstituted Complex physical 11701125 PTGES3 Affinity Capture-Western physical 11274138 YWHAZ Two-hybrid physical 10835362 YWHAQ Two-hybrid physical 10835362 YWHAQ Reconstituted Complex physical 10835362 YWHAQ Reconstituted Complex physical 10835362 MUS81 Synthetic Rescue genetic 19363487 PML Affinity Capture-Western physical 19567472 PML Affinity Capture-Western physical 19567472 UBC Affinity Capture-Western physical 15805468 MKRN1 Affinity Capture-Western physical 15805468 NAT10 Affinity Capture-Western physical 18082603 MDM2 Affinity Capture-Western physical 20453884 MDM2 Affinity Capture-Western physical 20453884 MDM2 Reconstituted Complex physical 20453884 UBC Affinity Capture-Western physical 20453884 MDM2 Biochemical Activity physical 20453884 UBC Affinity Capture-Western physical 20453884 SMG6 Affinity Capture-Western physical 22011238 GNL3L Affinity Capture-Western physical 19487455 TERF1 Reconstituted Complex physical 19487455 PTGES3 Two-hybrid physical 10197982 HSP90AA1 Reconstituted Complex physical 10197982 PTGES3 Reconstituted Complex physical 10197982