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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TNFRSF1A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IEA GO:0006693 prostaglandin metabolic process IEA GO:0006915 apoptosis TAS GO:0006954 inflammatory response IEA GO:0006954 inflammatory response ISS GO:0007165 signal transduction IEA GO:0008624 induction of apoptosis by extracellular signals TAS GO:0009812 flavonoid metabolic process IEA GO:0010628 positive regulation of gene expression IEA GO:0010629 negative regulation of gene expression IEA GO:0016101 diterpenoid metabolic process IEA GO:0019221 cytokine-mediated signaling pathway ISS GO:0032496 response to lipopolysaccharide IEA GO:0032715 negative regulation of interleukin-6 production IEA GO:0032760 positive regulation of tumor necrosis factor production IEA GO:0033013 tetrapyrrole metabolic process IEA GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033209 tumor necrosis factor-mediated signaling pathway TAS GO:0042742 defense response to bacterium IEA GO:0042981 regulation of apoptosis IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0043200 response to amino acid stimulus IEA GO:0043279 response to alkaloid IEA GO:0044419 interspecies interaction between organisms IEA GO:0045471 response to ethanol IEA GO:0045766 positive regulation of angiogenesis IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0050729 positive regulation of inflammatory response IEA GO:0050729 positive regulation of inflammatory response ISS GO:0071260 cellular response to mechanical stimulus IEP GO:0071392 cellular response to estradiol stimulus IEA cellular_component GO:0005576 extracellular region IEA GO:0005576 extracellular region NAS GO:0005615 extracellular space IEA GO:0005634 nucleus IEA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane TAS GO:0009986 cell surface IEA GO:0030424 axon IEA GO:0043234 protein complex IEA GO:0045121 membrane raft IDA GO:0045121 membrane raft IEA molecular_function GO:0002020 protease binding IEA GO:0004872 receptor activity IEA GO:0005031 tumor necrosis factor receptor activity IEA GO:0005031 tumor necrosis factor receptor activity TAS GO:0005488 binding IEA GO:0005515 protein binding IPI

Protein-protein interaction details for TNFRSF1A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PSMD2 Two-hybrid physical 7601280 PSMD2 Two-hybrid physical 9126987 SUMO1 Two-hybrid physical 10187798 FANCD2 Affinity Capture-MS physical 14743216 TNF Affinity Capture-MS physical 14743216 TNFRSF10B Co-purification physical 15659383 BID Co-purification physical 15659383 EZR Co-purification physical 15659383 FADD Co-purification physical 15659383 FAS Co-purification physical 15659383 FASLG Co-purification physical 15659383 MAPK8 Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 RHOA Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 TRPC4AP Affinity Capture-Western physical 14585990 TRPC4AP Reconstituted Complex physical 14585990 TNF Affinity Capture-Western physical 12887920 BCL10 Two-hybrid physical 10400625 TRAP1 Reconstituted Complex physical 7876093 CASP10 Affinity Capture-Western physical 9045686 RIPK2 Affinity Capture-Western physical 9642260 GRB2 Affinity Capture-Western physical 10359574 LTA Co-crystal Structure physical 8387891 BAG4 Affinity Capture-Western physical 9915703 TRADD Affinity Capture-Western physical 9915703 JAK1 Reconstituted Complex physical 9510175 JAK2 Reconstituted Complex physical 9510175 JAK2 Affinity Capture-Western physical 9510175 SUMO1 Two-hybrid physical 8906799 SUMO1 Reconstituted Complex physical 8906799 STAT1 Affinity Capture-Western physical 10848577 DAPK1 Affinity Capture-Western physical 12911633 IKBKB Affinity Capture-Western physical 10755617 IKBKG Affinity Capture-Western physical 10755617 TRADD Affinity Capture-Western physical 10187805 CEP110 Affinity Capture-Western physical 10187805 RIPK1 Affinity Capture-Western physical 11002422 PSMD2 Affinity Capture-Western physical 9126987 UBE2I Two-hybrid physical 9563508 UBE2I Reconstituted Complex physical 9563508 TNFRSF1A Two-hybrid physical 8077196 TRADD Affinity Capture-Western physical 9082980 NSMAF Two-hybrid physical 8808629 NSMAF Affinity Capture-Western physical 8808629 IKBKB Biochemical Activity physical 11002417 NOL3 Phenotypic Suppression genetic 9560245 RIPK1 Affinity Capture-Western physical 8985253 CRADD Affinity Capture-Western physical 8985253 CASP2 Affinity Capture-Western physical 8985253 TNFSF13 Reconstituted Complex physical 10706119 RIPK3 Affinity Capture-Western physical 10339433 MADD Reconstituted Complex physical 9115275 TRADD Affinity Capture-Western physical 8612133 RIPK1 Affinity Capture-Western physical 8612133 TRAF2 Affinity Capture-Western physical 8612133 TRADD Affinity Capture-Western physical 8565075 TRADD Two-hybrid physical 8565075 TRAF1 Affinity Capture-Western physical 8565075 TRAF2 Affinity Capture-Western physical 8565075 FADD Affinity Capture-Western physical 8565075 TNFRSF1A Affinity Capture-Western physical 10875917 TNFRSF1A FRET physical 10875917 BAG4 Reconstituted Complex physical 11909948 HSPA8 Reconstituted Complex physical 11909948 PSMD2 Reconstituted Complex physical 7601280 PIP4K2B Two-hybrid physical 9038203 PIP4K2B Reconstituted Complex physical 9038203 PIP4K2B Affinity Capture-Western physical 9038203 CASP7 Biochemical Activity physical 11755217 TRADD Affinity Capture-Western physical 8943045 TRAF2 Affinity Capture-Western physical 8943045 BIRC2 Affinity Capture-Western physical 8943045 LTB Reconstituted Complex physical 7995952 JAK1 Affinity Capture-Western physical 11801527 RIPK1 Affinity Capture-Western physical 18939944 TRADD Affinity Capture-Western physical 18939944 BIRC3 Affinity Capture-Western physical 18939944 RIPK1 Affinity Capture-Western physical 18724939 RIPK1 Affinity Capture-Western physical 18621737 RIPK1 Affinity Capture-Western physical 16968706 BRE Affinity Capture-Western physical 15465831 BRE Affinity Capture-Western physical 15465831 FYN Co-fractionation physical 12753742 CAV1 Co-fractionation physical 12753742 TNF Affinity Capture-Western physical 12753742 FASLG Affinity Capture-Western physical 12753742 UBC Affinity Capture-Western physical 12753742 TNF Affinity Capture-MS physical 15485837 BIRC3 Affinity Capture-Western physical 19815541 RIPK1 Affinity Capture-Western physical 19815541 TRAF2 Affinity Capture-Western physical 19815541 BIRC2 Affinity Capture-Western physical 19815541 RIPK1 Affinity Capture-Western physical 21113135 RIPK1 Affinity Capture-Western physical 20825417 RIPK1 Affinity Capture-Western physical 19773432 RIPK1 Affinity Capture-Western physical 21737329 TNF Reconstituted Complex physical 22099304 USP2 Affinity Capture-Western physical 22179575 RIPK1 Affinity Capture-Western physical 22179575 TRAF2 Affinity Capture-Western physical 22179575 USP2 Affinity Capture-Western physical 22179575 MAPK1 Biochemical Activity physical 11606045 RIPK1 Affinity Capture-Western physical 20448643 TRAF2 Affinity Capture-Western physical 20448643 TNFAIP3 Affinity Capture-Western physical 20448643