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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TOP2B (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000712resolution of meiotic recombination intermediatesIBA
GO:0000819sister chromatid segregationIBA
GO:0001764neuron migrationIEA
GO:0006261DNA-dependent DNA replicationIBA
GO:0006265DNA topological changeIBA
GO:0006265DNA topological changeIEA
GO:0006312mitotic recombinationIBA
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0007409axonogenesisIEA
GO:0030900forebrain developmentIEA
GO:0070683mitotic cell cycle G2/M transition decatenation checkpointIBA
cellular_component
GO:0000792heterochromatinIDA
GO:0000795synaptonemal complexIBA
GO:0005634nucleusIDA
GO:0005634nucleusIEA
GO:0005654nucleoplasmIDA
GO:0005694chromosomeIEA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIEA
GO:0005829cytosolIDA
GO:0009330DNA topoisomerase complex (ATP-hydrolyzing)IBA
GO:0071778WINAC complexIDA
molecular_function
GO:0000166nucleotide bindingIEA
GO:0003677DNA bindingIEA
GO:0003682chromatin bindingIDA
GO:0003918DNA topoisomerase (ATP-hydrolyzing) activityIBA
GO:0003918DNA topoisomerase (ATP-hydrolyzing) activityIEA
GO:0005080protein kinase C bindingIPI
GO:0005524ATP bindingIEA
GO:0008022protein C-terminus bindingIPI
GO:0008094DNA-dependent ATPase activityIBA
GO:0016853isomerase activityIEA
GO:0019899enzyme bindingIPI
GO:0042826histone deacetylase bindingIPI
GO:0046982protein heterodimerization activityIPI

Protein-protein interaction details for TOP2B (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
TOPBP1Two-hybridphysical9461304
BAZ1BAffinity Capture-MSphysical12837248
BAZ1BAffinity Capture-Westernphysical12837248
HDAC1Affinity Capture-Westernphysical11062478
HDAC2Affinity Capture-Westernphysical11062478
MTA2Affinity Capture-Westernphysical11062478
HDAC1Reconstituted Complexphysical11062478
HDAC2Reconstituted Complexphysical11062478
HDAC1Reconstituted Complexphysical11136718
HDAC1Two-hybridphysical11136718
TOP2AReconstituted Complexphysical8710863
TP53Affinity Capture-Westernphysical10666337
TP53Reconstituted Complexphysical10666337
SUMO1Two-hybridphysical10862613
SUMO1Reconstituted Complexphysical10862613
SUMO1Affinity Capture-Westernphysical10862613
CD3EAffinity Capture-Westernphysical8626450
CD3EReconstituted Complexphysical8626450
CSNK2BTwo-hybridphysical11710515
ESR1Affinity Capture-Westernphysical16794079
PARP1Affinity Capture-Westernphysical16794079
SUMO2Affinity Capture-MSphysical19394292
SRRM1Affinity Capture-MSphysical16159877
PMLAffinity Capture-MSphysical18212063
RARAAffinity Capture-MSphysical18212063
RARAReconstituted Complexphysical18212063
USF1Affinity Capture-Westernphysical19303849
SUMO1Reconstituted Complexphysical19596686
UBCAffinity Capture-MSphysical22178446