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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TP73 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA GO:0000187 activation of MAPK activity IEA GO:0001822 kidney development IEA GO:0001836 release of cytochrome c from mitochondria IEA GO:0006298 mismatch repair TAS GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent TAS GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006915 apoptosis IEA GO:0006954 inflammatory response IEA GO:0006974 response to DNA damage stimulus IEA GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA GO:0007049 cell cycle IEA GO:0007050 cell cycle arrest IEA GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis TAS GO:0009791 post-embryonic development IEA GO:0010165 response to X-ray IBA GO:0010243 response to organic nitrogen IEA GO:0010332 response to gamma radiation IBA GO:0021766 hippocampus development IEA GO:0030900 forebrain development IEA GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint IBA GO:0033326 cerebrospinal fluid secretion IEA GO:0034644 cellular response to UV IBA GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IBA GO:0043065 positive regulation of apoptosis IEA GO:0043508 negative regulation of JUN kinase activity IBA GO:0043508 negative regulation of JUN kinase activity IEA GO:0043524 negative regulation of neuron apoptosis IBA GO:0043524 negative regulation of neuron apoptosis IEA GO:0045665 negative regulation of neuron differentiation IEA GO:0045793 positive regulation of cell size IEA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048546 digestive tract morphogenesis IEA GO:0048666 neuron development IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0051262 protein tetramerization IEA cellular_component GO:0000785 chromatin IBA GO:0000785 chromatin IEA GO:0005634 nucleus IEA GO:0005667 transcription factor complex IBA GO:0005829 cytosol IBA molecular_function GO:0002039 p53 binding IBA GO:0002039 p53 binding IEA GO:0003677 DNA binding IEA GO:0003682 chromatin binding IBA GO:0003684 damaged DNA binding IBA GO:0003690 double-stranded DNA binding IBA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0043565 sequence-specific DNA binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0044212 transcription regulatory region DNA binding IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for TP73 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MDM2 Reconstituted Complex physical 10435614 MDM2 Affinity Capture-Western physical 10435614 GNB2L1 Two-hybrid physical 12761493 GNB2L1 Reconstituted Complex physical 12761493 GNB2L1 Affinity Capture-Western physical 12761493 GNB2L1 Affinity Capture-Western physical 12761493 RB1 Affinity Capture-Western physical 12761493 SUMO1 Two-hybrid physical 10961991 UBE2I Two-hybrid physical 10961991 CHD3 Two-hybrid physical 10961991 HIPK3 Two-hybrid physical 10961991 TDG Two-hybrid physical 10961991 TP73 Two-hybrid physical 10961991 ABL1 Reconstituted Complex physical 10391251 ABL1 Affinity Capture-Western physical 10391251 ABL1 Affinity Capture-Western physical 10391250 YAP1 Reconstituted Complex physical 11278685 YAP1 Affinity Capture-Western physical 11278685 CEBPZ Affinity Capture-Western physical 12534345 CEBPZ Reconstituted Complex physical 12534345 MDM2 Affinity Capture-Western physical 10207051 MDM2 Reconstituted Complex physical 10207051 HMGB1 Reconstituted Complex physical 11748232 HIPK2 Two-hybrid physical 11925430 NFYB Affinity Capture-Western physical 12167641 NFYC Affinity Capture-Western physical 12167641 MYC Affinity Capture-Western physical 12080043 MYC Affinity Capture-Western physical 12080043 MYC Reconstituted Complex physical 12080043 UBC Affinity Capture-Western physical 17592138 ITCH Reconstituted Complex physical 17592138 CHUK Affinity Capture-Western physical 17452332 CHUK Reconstituted Complex physical 17452332 ITCH Affinity Capture-Western physical 17110958 YAP1 Affinity Capture-Western physical 17110958 YAP1 Affinity Capture-Western physical 17110958 UBC Affinity Capture-Western physical 17110958 ADH5 Affinity Capture-Western physical 20308539 AGBL2 Affinity Capture-Western physical 20308539 AHCY Affinity Capture-Western physical 20308539 AKAP1 Affinity Capture-Western physical 20308539 ASF1A Affinity Capture-Western physical 20308539 ASPM Affinity Capture-Western physical 20308539 BRD8 Affinity Capture-Western physical 20308539 NPRL3 Affinity Capture-Western physical 20308539 C22orf28 Affinity Capture-Western physical 20308539 C4orf41 Affinity Capture-Western physical 20308539 C6orf165 Affinity Capture-Western physical 20308539 CDT1 Affinity Capture-Western physical 20308539 DAB2IP Affinity Capture-Western physical 20308539 DDX23 Affinity Capture-Western physical 20308539 DNAJB6 Affinity Capture-Western physical 20308539 DPH1 Affinity Capture-Western physical 20308539 EIF2C1 Affinity Capture-Western physical 20308539 EIF2C2 Affinity Capture-Western physical 20308539 GAS8 Affinity Capture-Western physical 20308539 IGF2BP1 Affinity Capture-Western physical 20308539 LOC613037 Affinity Capture-Western physical 20308539 JPH1 Affinity Capture-Western physical 20308539 LRPPRC Affinity Capture-Western physical 20308539 MTHFSD Affinity Capture-Western physical 20308539 MYL9 Affinity Capture-Western physical 20308539 N4BP2 Affinity Capture-Western physical 20308539 PAX6 Affinity Capture-Western physical 20308539 PIWIL1 Affinity Capture-Western physical 20308539 RNF38 Affinity Capture-Western physical 20308539 SASS6 Affinity Capture-Western physical 20308539 SMARCD2 Affinity Capture-Western physical 20308539 SPSB1 Affinity Capture-Western physical 20308539 STAG1 Affinity Capture-Western physical 20308539 TPM3 Affinity Capture-Western physical 20308539 TRMT11 Affinity Capture-Western physical 20308539 TTLL5 Affinity Capture-Western physical 20308539 UBE4B Affinity Capture-Western physical 16170377 UBE4B Affinity Capture-Western physical 16170377 ITCH Reconstituted Complex physical 15678106 ITCH Affinity Capture-Western physical 15678106 ITCH Affinity Capture-Western physical 15678106 UBC Affinity Capture-Western physical 15678106 NEDD4 Affinity Capture-Western physical 15678106 ITCH Biochemical Activity physical 15678106 RANBP9 Reconstituted Complex physical 15558019 RANBP9 Affinity Capture-Western physical 15558019 KDM1A Affinity Capture-Western physical 18573881 YAP1 Affinity Capture-Western physical 15893728 EP300 Affinity Capture-Western physical 15893728 HECW2 Affinity Capture-Western physical 12890487 HECW2 Affinity Capture-Western physical 12890487 HECW2 Reconstituted Complex physical 12890487 UBC Affinity Capture-Western physical 12890487 CCNG1 Affinity Capture-Western physical 12642871 EP300 Affinity Capture-Western physical 15454570 NFYB Affinity Capture-Western physical 15454570 NFYC Affinity Capture-Western physical 15454570 HDAC1 Affinity Capture-Western physical 15454570 HDAC1 Affinity Capture-Western physical 15454570 HDAC1 Reconstituted Complex physical 15454570 MDM4 Affinity Capture-Western physical 11223036 HDAC1 Affinity Capture-Western physical 17353261 HDAC2 Affinity Capture-Western physical 17353261 MDM2 Affinity Capture-Western physical 20588255 CUL1 Affinity Capture-Western physical 19581926 FBXO45 Affinity Capture-Western physical 19581926 FBXO45 Biochemical Activity physical 19581926 MDM2 Reconstituted Complex physical 21088494 MDM4 Reconstituted Complex physical 21088494 UBC Affinity Capture-Western physical 20185758 AZI1 Affinity Capture-Western physical 20185758 EP300 Co-purification physical 10648616 EP300 Co-purification physical 10648616 EP300 Affinity Capture-Western physical 10648616 EP300 Affinity Capture-Western physical 10648616 EP300 Reconstituted Complex physical 10648616 CREBBP Reconstituted Complex physical 10648616