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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TRAF6 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0000187 activation of MAPK activity TAS GO:0000209 protein polyubiquitination IDA GO:0001503 ossification IEA GO:0002218 activation of innate immune response TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002726 positive regulation of T cell cytokine production IMP GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis TAS GO:0007165 signal transduction IEA GO:0007249 I-kappaB kinase/NF-kappaB cascade TAS GO:0007250 activation of NF-kappaB-inducing kinase activity IMP GO:0007254 JNK cascade TAS GO:0008063 Toll signaling pathway TAS GO:0008624 induction of apoptosis by extracellular signals TAS GO:0016567 protein ubiquitination EXP GO:0031293 membrane protein intracellular domain proteolysis TAS GO:0032147 activation of protein kinase activity IDA GO:0032743 positive regulation of interleukin-2 production IMP GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042981 regulation of apoptosis IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IDA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade TAS GO:0043507 positive regulation of JUN kinase activity IDA GO:0043507 positive regulation of JUN kinase activity NAS GO:0045087 innate immune response TAS GO:0045672 positive regulation of osteoclast differentiation IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0050852 T cell receptor signaling pathway IMP GO:0050852 T cell receptor signaling pathway TAS GO:0050870 positive regulation of T cell activation IC GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0051403 stress-activated MAPK cascade TAS GO:0051865 protein autoubiquitination IDA GO:0051865 protein autoubiquitination TAS GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070534 protein K63-linked ubiquitination IDA GO:0070534 protein K63-linked ubiquitination IGI GO:0070555 response to interleukin-1 IDA GO:2000679 positive regulation of transcription regulatory region DNA binding IDA cellular_component GO:0005634 nucleus IDA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0005938 cell cortex IEA GO:0009898 internal side of plasma membrane ISS GO:0010008 endosome membrane TAS GO:0031965 nuclear membrane IDA GO:0035631 CD40 receptor complex ISS GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0004842 ubiquitin-protein ligase activity EXP GO:0004842 ubiquitin-protein ligase activity IDA GO:0004842 ubiquitin-protein ligase activity TAS GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0016874 ligase activity IEA GO:0019901 protein kinase binding IPI GO:0031435 mitogen-activated protein kinase kinase kinase binding IPI GO:0042826 histone deacetylase binding IPI GO:0043422 protein kinase B binding IPI GO:0046872 metal ion binding IEA GO:0047485 protein N-terminus binding IPI

Protein-protein interaction details for TRAF6 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TRAF2 Two-hybrid physical 16189514 EPPK1 Affinity Capture-MS physical 17353931 PFAS Affinity Capture-MS physical 17353931 MTHFD1 Affinity Capture-MS physical 17353931 NASP Affinity Capture-MS physical 17353931 VARS Affinity Capture-MS physical 17353931 VCP Affinity Capture-MS physical 17353931 IARS Affinity Capture-MS physical 17353931 GANAB Affinity Capture-MS physical 17353931 DDX3X Affinity Capture-MS physical 17353931 EIF4E2 Affinity Capture-MS physical 17353931 TARS Affinity Capture-MS physical 17353931 PAICS Affinity Capture-MS physical 17353931 ASXL2 Affinity Capture-MS physical 17353931 TJP2 Affinity Capture-MS physical 17353931 VDAC1 Affinity Capture-MS physical 17353931 CTPS Affinity Capture-MS physical 17353931 MCM7 Affinity Capture-MS physical 17353931 KCNQ1 Affinity Capture-MS physical 14743216 PSMB5 Affinity Capture-MS physical 14743216 PSMC1 Affinity Capture-MS physical 14743216 PSMC2 Affinity Capture-MS physical 14743216 PSMC3 Affinity Capture-MS physical 14743216 PSMD1 Affinity Capture-MS physical 14743216 PSMD12 Affinity Capture-MS physical 14743216 PSMD13 Affinity Capture-MS physical 14743216 PSMD3 Affinity Capture-MS physical 14743216 PSMD7 Affinity Capture-MS physical 14743216 MAST2 Affinity Capture-Western physical 15308666 ZFAND5 Affinity Capture-Western physical 14754897 TAB2 Affinity Capture-Western physical 14633987 TAB3 Affinity Capture-Western physical 14633987 MAP3K7 Affinity Capture-Western physical 14633987 SIGIRR Affinity Capture-Western physical 12925853 SIGIRR Affinity Capture-Western physical 12925853 RIPK2 Affinity Capture-Western physical 9642260 SRC Affinity Capture-Western physical 10635328 MAP3K5 Affinity Capture-Western physical 9774977 CD40 Reconstituted Complex physical 9990007 SQSTM1 Affinity Capture-Western physical 10747026 SQSTM1 Affinity Capture-Western physical 10747026 PRKCZ Affinity Capture-Western physical 10747026 IRAK1 Affinity Capture-Western physical 10383454 IRAK2 Affinity Capture-Western physical 10383454 IRAK3 Affinity Capture-Western physical 10383454 TNFRSF11A Affinity Capture-Western physical 11809792 TDP2 Affinity Capture-Western physical 10764746 MAP3K5 Affinity Capture-Western physical 10523862 IRAK1 Affinity Capture-Western physical 11518704 NGFR Affinity Capture-Western physical 10514511 XIAP Affinity Capture-Western physical 12048196 STRADB Affinity Capture-Western physical 12048196 TNFRSF11A Reconstituted Complex physical 9685412 TNFRSF11A Reconstituted Complex physical 10075662 IRAK1 Affinity Capture-Western physical 8837778 EDA2R Affinity Capture-Western physical 12270937 SYK Affinity Capture-Western physical 11418661 CD40 Reconstituted Complex physical 9384571 TNFAIP3 Affinity Capture-Western physical 9928991 ZNF675 Affinity Capture-Western physical 11751921 ZNF675 Phenotypic Suppression genetic 11751921 ZNF675 Two-hybrid physical 11751921 ZNF675 Reconstituted Complex physical 11751921 ZNF675 Phenotypic Enhancement genetic 11751921 TNFRSF11A Reconstituted Complex physical 9852070 TNFRSF11A Reconstituted Complex physical 10025951 TNFRSF11A Affinity Capture-Western physical 10025951 TRAF3IP1 Reconstituted Complex physical 10791955 TNFRSF13B Two-hybrid physical 10880535 TNFRSF13B Affinity Capture-Western physical 10880535 TRIM37 Reconstituted Complex physical 11279055 USP7 Reconstituted Complex physical 11279055 SPOP Reconstituted Complex physical 11279055 TIFA Affinity Capture-Western physical 12566447 IRAK1 Affinity Capture-Western physical 12566447 IRAK1 Affinity Capture-Western physical 11960013 IRAK4 Affinity Capture-Western physical 11960013 IRAK4 Affinity Capture-Western physical 11960013 TAX1BP1 Two-hybrid physical 10920205 TAX1BP1 Affinity Capture-Western physical 10920205 TAX1BP1 Affinity Capture-Western physical 10920205 IRAK1 Affinity Capture-Western physical 10920205 IRAK1 Affinity Capture-Western physical 10920205 ZRANB1 Affinity Capture-Western physical 11463333 OTUD7B Affinity Capture-Western physical 11463333 TNFAIP3 Affinity Capture-Western physical 11463333 UBE2N Phenotypic Suppression genetic 11057907 UBE2N Reconstituted Complex physical 11057907 UBE2V1 Reconstituted Complex physical 11057907 TAB2 Affinity Capture-Western physical 10882101 TAB2 Affinity Capture-Western physical 10882101 TAB1 Affinity Capture-Western physical 10882101 MAP3K7 Affinity Capture-Western physical 10882101 IRAK1 Two-hybrid physical 11259596 TAB2 Two-hybrid physical 11259596 TAB1 Affinity Capture-Western physical 10094049 MAP3K7 Affinity Capture-Western physical 10094049 TAB2 Affinity Capture-Western physical 11259596 MAP3K7 Affinity Capture-Western physical 11259596 MAP3K7 Affinity Capture-Western physical 10921914 MAP3K5 Affinity Capture-Western physical 10921914 MAP3K7 Affinity Capture-Western physical 10921914 MAP3K14 Affinity Capture-Western physical 10921914 TIRAP Phenotypic Suppression genetic 11544529 MYD88 Phenotypic Suppression genetic 11544529 IRAK1 Affinity Capture-Western physical 9374458 IRAK2 Affinity Capture-Western physical 9374458 MAP3K7 Affinity Capture-Western physical 19112497 TAB2 Affinity Capture-Western physical 19112497 TAB1 Affinity Capture-Western physical 19112497 PSEN1 Affinity Capture-Western physical 19012753 HSPB2 Affinity Capture-Western physical 18950704 HSPB2 Affinity Capture-Western physical 18950704 RUNX1 Affinity Capture-Western physical 18768464 FHL2 Affinity Capture-Western physical 18768464 FHL2 Biochemical Activity physical 18768464 TGFBR1 Affinity Capture-Western physical 18758450 MAP3K7 Affinity Capture-Western physical 18758450 BMPR1B Affinity Capture-Western physical 18758450 UBC Affinity Capture-Western physical 18724939 PPP4C Two-hybrid physical 18634786 PPP4C Two-hybrid physical 18634786 PPP4C Affinity Capture-Western physical 18634786 PPP4C Affinity Capture-Western physical 18634786 UBC Affinity Capture-Western physical 18634786 UBC Affinity Capture-Western physical 18617513 TRAF6 Biochemical Activity physical 18617513 IKBKG Reconstituted Complex physical 18617513 NTRK2 Affinity Capture-Western physical 18457658 NTRK1 Affinity Capture-Western physical 18457658 UBC Affinity Capture-Western physical 18347055 PELI3 Affinity Capture-Western physical 18326498 UBC Affinity Capture-Western physical 18299187 TAB2 Affinity Capture-Western physical 18299187 SDCBP Affinity Capture-Western physical 18234474 SDCBP Affinity Capture-Western physical 18234474 IRAK1 Affinity Capture-Western physical 18234474 IKBKG Reconstituted Complex physical 18180283 TAB2 Affinity Capture-Western physical 18180283 TNFAIP3 Affinity Capture-Western physical 18164316 UBC Affinity Capture-Western physical 18164316 UBC Affinity Capture-Western physical 17942533 IRAK2 Affinity Capture-Western physical 17878161 IL17RA Affinity Capture-Western physical 17346928 IL17RA Affinity Capture-Western physical 17346928 UBC Affinity Capture-Western physical 17135271 IKBKG Biochemical Activity physical 17135271 ZMYND11 Affinity Capture-Western physical 16382137 UBE2N Two-hybrid physical 19549727 UBE2D1 Two-hybrid physical 19549727 UBE2D2 Two-hybrid physical 19549727 UBE2D3 Two-hybrid physical 19549727 UBE2D4 Two-hybrid physical 19549727 UEVLD Two-hybrid physical 19549727 MAP3K7 Affinity Capture-Western physical 16543409 SOCS3 Affinity Capture-Western physical 16543409 IRF8 Affinity Capture-Western physical 16484229 UBC Affinity Capture-Western physical 16484229 IRF7 Affinity Capture-Western physical 15361868 HSPA4 Affinity Capture-Western physical 16697380 UBC Affinity Capture-Western physical 16697380 MALT1 Affinity Capture-Western physical 15125833 MALT1 Reconstituted Complex physical 15125833 MAP3K7 Affinity Capture-Western physical 14633987 UBC Affinity Capture-Western physical 14550571 CYLD Biochemical Activity physical 12917691 UBC Affinity Capture-Western physical 12917689 SMURF1 Phenotypic Suppression genetic 19937093 IRAK1 Affinity Capture-Western physical 11287640 IRAK1 Affinity Capture-Western physical 11287640 UBC Affinity Capture-Western physical 17562858 NUMBL Affinity Capture-Western physical 20079715 NUMBL Reconstituted Complex physical 20079715 MARCH5 Affinity Capture-Western physical 21625535 TRAIP Affinity Capture-Western physical 17544371 UBE2N Co-fractionation physical 19810754 UBC Affinity Capture-Western physical 17314283 RANBP9 Two-hybrid physical 21805090 RANBP9 Reconstituted Complex physical 21805090 RANBP9 Affinity Capture-Western physical 21805090 RANBP9 Affinity Capture-Western physical 21805090 RANBP9 FRET physical 21805090 IRF7 Affinity Capture-Western physical 21183682 PARK7 Affinity Capture-Western physical 20634198 PARK7 Affinity Capture-Western physical 20634198 SNCA Affinity Capture-Western physical 20634198 UBE2N Two-hybrid physical 21113135 BIRC2 Affinity Capture-Western physical 20097753 BIRC3 Affinity Capture-Western physical 20097753 UBC Affinity Capture-Western physical 20097753 OTUB1 Affinity Capture-Western physical 19996094 OTUB2 Affinity Capture-Western physical 19996094 UBC Affinity Capture-Western physical 19996094 BECN1 Affinity Capture-Western physical 20501938 BECN1 Biochemical Activity physical 20501938 MAP3K11 Affinity Capture-Western physical 19586614 MAP3K3 Affinity Capture-Western physical 19903815 MAP3K3 Reconstituted Complex physical 19903815 MAP3K3 Co-localization physical 19903815 SQSTM1 Co-localization physical 19903815 TLR4 Affinity Capture-Western physical 21911421 TLR9 Affinity Capture-Western physical 21911421 TLR3 Affinity Capture-Western physical 21911421 STUB1 Reconstituted Complex physical 21911421 STUB1 Affinity Capture-Western physical 21911421 UBC Affinity Capture-Western physical 21896478 IRAK1 Affinity Capture-Western physical 21220427 UBC Affinity Capture-Western physical 21220427 UBC Affinity Capture-Western physical 21220427 IRAK1 Affinity Capture-Western physical 21220427 TNFAIP3 Affinity Capture-Western physical 21220427 RUSC1 Affinity Capture-Western physical 19365808 UBC Affinity Capture-Western physical 19825828 IL17A Affinity Capture-Western physical 19825828 TRAF3IP2 Biochemical Activity physical 19825828 UBC Affinity Capture-Western physical 17562285 UBE2N Co-crystal Structure physical 19465916 UBE2N Two-hybrid physical 19465916 UBC Two-hybrid physical 19465916 TRAF6 FRET physical 19465916 PEBP1 Affinity Capture-Western physical 20043910 IRAK1 Affinity Capture-Western physical 20043910 UBC Affinity Capture-Western physical 20043910 UBC Affinity Capture-Western physical 19201866 SQSTM1 Affinity Capture-Western physical 19201866 MAP3K7 Biochemical Activity physical 19675569 TAB2 Affinity Capture-Western physical 19675569 UBC Reconstituted Complex physical 19675569 TRAF6 Biochemical Activity physical 19675569 IKBKG Affinity Capture-Western physical 20529958 IKBKG Reconstituted Complex physical 20529958 UBC Affinity Capture-Western physical 20932475 ATM Reconstituted Complex physical 20932475 BIRC2 Affinity Capture-Western physical 20932475 IKBKG Affinity Capture-Western physical 20932475 TICAM1 Two-hybrid physical 20047764 TICAM1 Affinity Capture-Western physical 20047764 IRAK1 Affinity Capture-Western physical 22033459 UBC Affinity Capture-Western physical 22033459 HTT Affinity Capture-Western physical 21454471 HTT Affinity Capture-Western physical 21454471 MSR1 Affinity Capture-Western physical 21460221 UBC Affinity Capture-Western physical 21460221 UBC Affinity Capture-Western physical 19592251 USP4 Affinity Capture-Western physical 22029577 USP4 Affinity Capture-Western physical 22029577 USP4 Reconstituted Complex physical 22029577 UBC Affinity Capture-Western physical 22029577 USP4 Biochemical Activity physical 22029577 UBC Reconstituted Complex physical 22029577 FOXG1 Affinity Capture-Western physical 19683680 UBC Affinity Capture-Western physical 20512936 TRAF6 Affinity Capture-Western physical 20512936 IRF7 Affinity Capture-Western physical 22095711 UBC Affinity Capture-Western physical 21454471 IRAK2 Affinity Capture-MS physical 21903422 MAVS Affinity Capture-MS physical 21903422 TRAF2 Affinity Capture-MS physical 21903422 IRAK2 Affinity Capture-MS physical 21903422 WDR5 Affinity Capture-Western physical 20080758 USP7 Affinity Capture-Western physical 18952891 UBC Affinity Capture-Western physical 18952891 NLRX1 Affinity Capture-Western physical 21703539 UBC Affinity Capture-Western physical 21185369 UBC Affinity Capture-Western physical 21068390 NR0B2 Affinity Capture-Western physical 21725320 UBC Affinity Capture-Western physical 21078302