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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TSC2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IEA GO:0001843 neural tube closure IEA GO:0001843 neural tube closure ISS GO:0006469 negative regulation of protein kinase activity IEA GO:0006469 negative regulation of protein kinase activity ISS GO:0006606 protein import into nucleus IEA GO:0006606 protein import into nucleus ISS GO:0006897 endocytosis TAS GO:0006953 acute-phase response IEA GO:0007050 cell cycle arrest TAS GO:0007165 signal transduction IEA GO:0007507 heart development IEA GO:0007507 heart development ISS GO:0008104 protein localization ISS GO:0008285 negative regulation of cell proliferation IBA GO:0008285 negative regulation of cell proliferation ISS GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0014067 negative regulation of phosphatidylinositol 3-kinase cascade IEA GO:0014067 negative regulation of phosphatidylinositol 3-kinase cascade ISS GO:0016192 vesicle-mediated transport TAS GO:0030030 cell projection organization IEA GO:0030100 regulation of endocytosis IEA GO:0030100 regulation of endocytosis ISS GO:0030178 negative regulation of Wnt receptor signaling pathway IBA GO:0030178 negative regulation of Wnt receptor signaling pathway IEA GO:0032007 negative regulation of TOR signaling cascade IBA GO:0032007 negative regulation of TOR signaling cascade IEA GO:0043407 negative regulation of MAP kinase activity IEA GO:0043491 protein kinase B signaling cascade IBA GO:0043491 protein kinase B signaling cascade ISS GO:0043547 positive regulation of GTPase activity IDA GO:0045184 establishment of protein localization IEA GO:0045792 negative regulation of cell size IBA GO:0045792 negative regulation of cell size IEA GO:0046626 regulation of insulin receptor signaling pathway IBA GO:0046626 regulation of insulin receptor signaling pathway IEA GO:0046626 regulation of insulin receptor signaling pathway ISS GO:0048009 insulin-like growth factor receptor signaling pathway IBA GO:0048009 insulin-like growth factor receptor signaling pathway IEA GO:0048009 insulin-like growth factor receptor signaling pathway ISS GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050918 positive chemotaxis IEA GO:0050918 positive chemotaxis ISS GO:0051056 regulation of small GTPase mediated signal transduction IEA GO:0051260 protein homooligomerization IEA GO:0051291 protein heterooligomerization IEA GO:0051726 regulation of cell cycle IBA GO:0051726 regulation of cell cycle IEA GO:0051898 negative regulation of protein kinase B signaling cascade IEA GO:0051898 negative regulation of protein kinase B signaling cascade ISS cellular_component GO:0005622 intracellular IEA GO:0005624 membrane fraction IDA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005792 microsome IEA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol IDA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005901 caveola IEA GO:0016020 membrane IEA GO:0030425 dendrite IEA GO:0030426 growth cone IEA GO:0033596 TSC1-TSC2 complex IDA GO:0043025 neuronal cell body IEA GO:0043234 protein complex IEA GO:0044430 cytoskeletal part IEA GO:0048471 perinuclear region of cytoplasm IDA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0005096 GTPase activator activity IDA GO:0005096 GTPase activator activity IEA GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0042803 protein homodimerization activity IPI GO:0046982 protein heterodimerization activity IEA GO:0071889 14-3-3 protein binding IEA

Protein-protein interaction details for TSC2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID YWHAQ Affinity Capture-MS physical 17353931 RHEB Affinity Capture-Western physical 12842888 RAP1A Affinity Capture-Western physical 12842888 RALA Affinity Capture-Western physical 12842888 YWHAZ Two-hybrid physical 12176984 YWHAZ Reconstituted Complex physical 12176984 AKT1 Affinity Capture-Western physical 12167664 AKT1 Affinity Capture-Western physical 15342917 CAV1 Co-purification physical 12147258 FOXO1 Affinity Capture-Western physical 17077083 FOXO1 Reconstituted Complex physical 17077083 FOXO1 Co-localization physical 17077083 GSK3B Affinity Capture-Western physical 12511557 PAM Two-hybrid physical 14559897 PRKAA1 Affinity Capture-Western physical 14651849 PTK2 Affinity Capture-Western physical 17043358 PTK2 Reconstituted Complex physical 17043358 RAB5A Co-purification physical 12147258 RAP1A Co-purification physical 12147258 RHEB Biochemical Activity physical 12869586 RHEB Biochemical Activity physical 12820960 RHEB Biochemical Activity physical 12771962 RHEB Biochemical Activity physical 17077083 RHEB Biochemical Activity physical 12842888 RPS6KA1 Affinity Capture-Western physical 15342917 TSC1 Affinity Capture-Western physical 12167664 TSC1 Affinity Capture-Western physical 11741833 TSC1 Affinity Capture-Western physical 11290735 TSC1 Affinity Capture-Western physical 9580671 TSC1 Two-hybrid physical 12176984 TSC1 Affinity Capture-Western physical 15340059 TSC1 Affinity Capture-Western physical 12511557 TSC1 Two-hybrid physical 9580671 TSC1 Co-localization physical 9580671 TSC1 Affinity Capture-Western physical 15851026 TSC1 Affinity Capture-Western physical 16636147 TSC1 Affinity Capture-Western physical 17077083 AKT1 Reconstituted Complex physical 12167664 AKT1 Affinity Capture-Western physical 12167664 CCND1 Affinity Capture-Western physical 16357142 CCND2 Affinity Capture-Western physical 16357142 CCND3 Affinity Capture-Western physical 16357142 CDKN1B Affinity Capture-Western physical 15355997 FOXO1 Affinity Capture-Western physical 17077083 GSK3B Biochemical Activity physical 16959574 GSK3B Affinity Capture-Western physical 12511557 PAM Affinity Capture-Western physical 14559897 PAM Co-localization physical 14559897 PLK1 Affinity Capture-Western physical 16339216 PRKAA1 Reconstituted Complex physical 14651849 PRKAA1 Reconstituted Complex physical 15261145 PRKAA1 Affinity Capture-Western physical 14651849 MAPK1 Reconstituted Complex physical 15851026 MAPK1 Affinity Capture-Western physical 15851026 PTK2 Affinity Capture-Western physical 17043358 PTK2 Reconstituted Complex physical 17043358 RHEB Affinity Capture-Western physical 15854902 RHEB Reconstituted Complex physical 15854902 RPS6KA1 Reconstituted Complex physical 15757502 RPS6KA1 Reconstituted Complex physical 15342917 RPS6KA1 Affinity Capture-Western physical 15342917 SKP2 Phenotypic Suppression genetic 15355997 TSC1 Affinity Capture-Western physical 15851026 TSC1 Affinity Capture-Western physical 14651849 TSC1 Affinity Capture-MS physical 15963462 TSC1 Affinity Capture-Western physical 16424383 TSC1 Affinity Capture-Western physical 16339216 TSC1 Affinity Capture-Western physical 17077083 TSC1 Affinity Capture-Western physical 14551205 TSC1 Affinity Capture-Western physical 11741833 TSC1 Two-hybrid physical 11741833 TSC1 Affinity Capture-Western physical 11741832 TSC1 Affinity Capture-Western physical 11290735 TSC1 Affinity Capture-Western physical 10807585 TSC1 Affinity Capture-Western physical 9580671 TSC1 Affinity Capture-Western physical 12167664 UBE3A Reconstituted Complex physical 15175323 AXIN1 Affinity Capture-Western physical 12511557 AXIN1 Affinity Capture-Western physical 12511557 TSC1 Affinity Capture-Western physical 10915759 FBXW5 Affinity Capture-Western physical 18381890 UBC Affinity Capture-Western physical 18298802 UBE3A Affinity Capture-Western physical 18298802 UBE3A Reconstituted Complex physical 18298802 TBC1D7 Affinity Capture-Western physical 17658474 TSC1 Affinity Capture-Western physical 17658474 TBC1D7 Affinity Capture-Western physical 17658474 TSC1 Affinity Capture-Western physical 17658474 TBC1D7 Reconstituted Complex physical 17658474 YWHAB Affinity Capture-Western physical 12582162 YWHAB Affinity Capture-Western physical 12468542 YWHAB Affinity Capture-Western physical 12364343 YWHAB Two-hybrid physical 12176984 YWHAB Affinity Capture-Western physical 12468542 YWHAB Affinity Capture-Western physical 12364343 YWHAB Affinity Capture-Western physical 16636147 YWHAB Affinity Capture-Western physical 12176984 UBC Affinity Capture-Western physical 11175345 TSC1 Affinity Capture-Western physical 11175345 UBC Affinity Capture-MS physical 16196087 YWHAQ Affinity Capture-MS physical 20618440 YWHAQ Affinity Capture-MS physical 15161933 YWHAQ Affinity Capture-Western physical 15161933 YWHAB Affinity Capture-MS physical 15324660 GRB2 Two-hybrid physical 18624398 TK1 Two-hybrid physical 21900206 PIN1 Two-hybrid physical 21900206 UBC Affinity Capture-MS physical 21987572