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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for VAV1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006351 transcription, DNA-dependent TAS GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006909 phagocytosis IEA GO:0006915 apoptosis TAS GO:0006955 immune response IEA GO:0007229 integrin-mediated signaling pathway IEA GO:0007264 small GTPase mediated signal transduction TAS GO:0007596 blood coagulation TAS GO:0008624 induction of apoptosis by extracellular signals TAS GO:0030168 platelet activation TAS GO:0031295 T cell costimulation TAS GO:0035023 regulation of Rho protein signal transduction IEA GO:0035556 intracellular signal transduction IEA GO:0042110 T cell activation IEA GO:0043087 regulation of GTPase activity IEA GO:0045785 positive regulation of cell adhesion IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0051056 regulation of small GTPase mediated signal transduction TAS cellular_component GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS molecular_function GO:0003700 sequence-specific DNA binding transcription factor activity TAS GO:0005085 guanyl-nucleotide exchange factor activity IEA GO:0005085 guanyl-nucleotide exchange factor activity TAS GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA GO:0005515 protein binding IPI GO:0030676 Rac guanyl-nucleotide exchange factor activity IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for VAV1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID XRCC6 Two-hybrid physical 8524317 EZH2 Two-hybrid physical 8649418 EMD Two-hybrid physical 12755701 EZH2 Reconstituted Complex physical 8649418 EZH2 Affinity Capture-Western physical 8649418 PRKCQ Phenotypic Enhancement genetic 10725744 PRKCQ Affinity Capture-Western physical 10725744 PRKCQ Affinity Capture-Western physical 10725744 BLNK Affinity Capture-Western physical 9697839 PLCG1 Affinity Capture-Western physical 9891995 PIK3R1 Affinity Capture-Western physical 9891995 PIK3R1 Affinity Capture-Western physical 9891995 PLCG1 Affinity Capture-Western physical 9891995 PIK3R1 Reconstituted Complex physical 9891995 XRCC5 Affinity Capture-Western physical 10673353 TYK2 Affinity Capture-Western physical 10673353 TEC Affinity Capture-Western physical 11328862 PRLR Reconstituted Complex physical 11328862 RAC1 Affinity Capture-Western physical 11287617 CDC42 Affinity Capture-Western physical 11287617 JUN Biochemical Activity physical 11287617 SOCS1 Affinity Capture-Western physical 10022833 EPOR Affinity Capture-Western physical 9162069 PIK3R1 Affinity Capture-Western physical 9162069 PIK3R1 Affinity Capture-Western physical 9162069 PIK3R1 Reconstituted Complex physical 9162069 JAK2 Affinity Capture-Western physical 9162069 JAK2 Biochemical Activity physical 9162069 BTK Affinity Capture-Western physical 9201297 PRLR Affinity Capture-Western physical 7768923 PRLR Affinity Capture-Western physical 7768923 SH3BP2 Affinity Capture-Western physical 11390470 SH3BP2 Far Western physical 11390470 PDGFRB Affinity Capture-Western physical 10938113 EGFR Affinity Capture-Western physical 10938113 SLA Affinity Capture-Western physical 10662792 SLA Reconstituted Complex physical 10662792 SHB Affinity Capture-Western physical 12084069 SHB Reconstituted Complex physical 12084069 LAT Reconstituted Complex physical 11368773 ABL1 Reconstituted Complex physical 11790798 ABL1 Two-hybrid physical 11790798 ABL1 Affinity Capture-Western physical 11790798 ABL1 Biochemical Activity physical 11790798 RACGAP1 Reconstituted Complex physical 10748082 SYK Two-hybrid physical 8986718 SYK Affinity Capture-Western physical 8986718 SYK Reconstituted Complex physical 8986718 FCER1A Affinity Capture-Western physical 8900182 RAF1 Affinity Capture-Western physical 8900182 MAPK1 Affinity Capture-Western physical 8900182 MAP2K1 Affinity Capture-Western physical 8900182 GRB2 Affinity Capture-Western physical 8900182 SYK Affinity Capture-Western physical 8900182 ARHGDIB Two-hybrid physical 10664460 ARHGDIB Affinity Capture-Western physical 10664460 ARHGDIB Reconstituted Complex physical 10664460 FYN Affinity Capture-Western physical 9822663 JAK2 Affinity Capture-Western physical 7530656 HNRNPK Affinity Capture-Western physical 8051112 PAG1 Reconstituted Complex physical 10790433 CBLB Affinity Capture-Western physical 11857085 GRB2 Reconstituted Complex physical 7809090 GRB2 Affinity Capture-Western physical 7809090 CBL Affinity Capture-Western physical 9200440 CBL Affinity Capture-Western physical 9200440 CBL Reconstituted Complex physical 9200440 CBL Far Western physical 9200440 CD19 Affinity Capture-Western physical 7528218 CBL Affinity Capture-Western physical 11331248 SYK Affinity Capture-Western physical 11331248 SYK Biochemical Activity physical 11331248 LCP2 Affinity Capture-Western physical 9047237 PTPN6 Reconstituted Complex physical 8632004 SIAH2 Two-hybrid physical 10207103 GRB2 Two-hybrid physical 10207103 SIAH1 Two-hybrid physical 10207103 SIAH2 Reconstituted Complex physical 10207103 SIAH2 Affinity Capture-Western physical 10207103 IL6ST Reconstituted Complex physical 9013873 MAPK1 Affinity Capture-Western physical 9013873 GRB2 Affinity Capture-Western physical 9013873 S100B Affinity Capture-Western physical 10394361 S100B Affinity Capture-Western physical 10394361 S100B Reconstituted Complex physical 10394361 ZAP70 Reconstituted Complex physical 7798261 PLCG2 Affinity Capture-Western physical 10981967 LAT Reconstituted Complex physical 12186560 LAT Affinity Capture-Western physical 12186560 PTK2B Reconstituted Complex physical 10867021 DOCK2 Affinity Capture-Western physical 12393632 XRCC6 Reconstituted Complex physical 8524317 XRCC6 Affinity Capture-Western physical 8524317 LCP2 Reconstituted Complex physical 8703037 INSR Reconstituted Complex physical 7535775 EZH2 Affinity Capture-Western physical 15882624 SUZ12 Affinity Capture-Western physical 15882624 EED Affinity Capture-Western physical 15882624 PHAX Two-hybrid physical 21900206 TUBA1A Affinity Capture-Western physical 8530437 TUBB Affinity Capture-Western physical 8530437 TUBA1A Affinity Capture-Western physical 8530437 ZAP70 Affinity Capture-Western physical 8530437 TUBA1A Reconstituted Complex physical 8530437 UBC Affinity Capture-Western physical 12881521 CBL Affinity Capture-Western physical 12881521