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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ITCH (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001558 regulation of cell growth NAS GO:0002218 activation of innate immune response TAS GO:0002669 positive regulation of T cell anergy IEA GO:0006464 protein modification process IEA GO:0006511 ubiquitin-dependent protein catabolic process IDA GO:0006511 ubiquitin-dependent protein catabolic process NAS GO:0006954 inflammatory response NAS GO:0009615 response to virus IEA GO:0016567 protein ubiquitination IDA GO:0016567 protein ubiquitination NAS GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA GO:0032088 negative regulation of NF-kappaB transcription factor activity ISS GO:0032480 negative regulation of type I interferon production TAS GO:0035519 protein K29-linked ubiquitination IDA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA GO:0043066 negative regulation of apoptosis IMP GO:0044419 interspecies interaction between organisms IEA GO:0045087 innate immune response TAS GO:0045732 positive regulation of protein catabolic process IEA GO:0046329 negative regulation of JNK cascade IEA GO:0046329 negative regulation of JNK cascade ISS GO:0046642 negative regulation of alpha-beta T cell proliferation IEA GO:0046718 entry of virus into host cell TAS GO:0050687 negative regulation of defense response to virus IEA GO:0050687 negative regulation of defense response to virus IMP GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070534 protein K63-linked ubiquitination IDA GO:0070936 protein K48-linked ubiquitination IDA GO:0070936 protein K48-linked ubiquitination IEA GO:0090085 regulation of protein deubiquitination IEA GO:0090085 regulation of protein deubiquitination ISS cellular_component GO:0005622 intracellular IEA GO:0005624 membrane fraction IEA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005938 cell cortex IEA GO:0031410 cytoplasmic vesicle IEA molecular_function GO:0004842 ubiquitin-protein ligase activity IDA GO:0004842 ubiquitin-protein ligase activity NAS GO:0005515 protein binding IPI GO:0016874 ligase activity IEA GO:0016881 acid-amino acid ligase activity IEA GO:0043021 ribonucleoprotein binding IPI GO:0045236 CXCR chemokine receptor binding IPI

Protein-protein interaction details for ITCH (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NEDD9 Two-hybrid physical 15051726 SFN Affinity Capture-MS physical 15778465 NEDD9 Affinity Capture-Western physical 15051726 NEDD9 Reconstituted Complex physical 15051726 NEDD9 Reconstituted Complex physical 15051726 NUMB Reconstituted Complex physical 12682059 NUMB Affinity Capture-Western physical 12682059 NUMB Affinity Capture-Western physical 12682059 SCNN1A Far Western physical 11244092 SCNN1B Far Western physical 11244092 ATN1 Two-hybrid physical 9647693 ATN1 Reconstituted Complex physical 9647693 RIPK1 Affinity Capture-Western physical 19131965 RNF11 Affinity Capture-Western physical 19131965 CXCR4 Reconstituted Complex physical 19116316 CXCR4 Affinity Capture-Western physical 19116316 CXCR4 FRET physical 19116316 CXCR4 Reconstituted Complex physical 19116316 ARRB2 Affinity Capture-Western physical 18544533 ARRB1 Affinity Capture-Western physical 18544533 ITCH Biochemical Activity physical 18718449 ITCH Affinity Capture-Western physical 18718449 NFE2 Biochemical Activity physical 18718448 NFE2 Affinity Capture-Western physical 18718448 NUMB Reconstituted Complex physical 18628966 DTX1 Reconstituted Complex physical 18628966 CFLAR Affinity Capture-Western physical 18559494 TP53 Affinity Capture-Western physical 18559494 ERBB4 Affinity Capture-Western physical 18334649 ERBB4 Affinity Capture-Western physical 18334649 ERBB4 Reconstituted Complex physical 18334649 ARRB2 Affinity Capture-Western physical 17947233 ARR3 Affinity Capture-Western physical 17947233 ARRB2 Reconstituted Complex physical 17947233 N4BP1 Affinity Capture-Western physical 17592138 N4BP1 Reconstituted Complex physical 17592138 ITCH Biochemical Activity physical 17592138 TP73 Reconstituted Complex physical 17592138 UBE2L3 Reconstituted Complex physical 17719543 UBC Reconstituted Complex physical 17719543 USP13 Affinity Capture-MS physical 19615732 ERBB4 Far Western physical 17463226 ERBB4 Affinity Capture-Western physical 17463226 ERBB4 Reconstituted Complex physical 17463226 TP73 Affinity Capture-Western physical 17110958 YAP1 Affinity Capture-Western physical 17110958 USP9X Affinity Capture-Western physical 17038327 USP9X Reconstituted Complex physical 17038327 UBC Affinity Capture-Western physical 17038327 UBC Affinity Capture-Western physical 17038327 ITCH Biochemical Activity physical 17038327 JUN Reconstituted Complex physical 16901904 FYN Affinity Capture-Western physical 16387660 FYN Affinity Capture-Western physical 16387660 FYN Reconstituted Complex physical 16387660 SMAD7 Affinity Capture-Western physical 15946939 SMAD7 Affinity Capture-Western physical 15946939 MLANA Affinity Capture-Western physical 15703212 MLANA Reconstituted Complex physical 15703212 TP73 Reconstituted Complex physical 15678106 TP73 Affinity Capture-Western physical 15678106 TP73 Affinity Capture-Western physical 15678106 TP73 Biochemical Activity physical 15678106 NEDD9 Two-hybrid physical 15051726 SMAD3 Reconstituted Complex physical 15051726 NEDD9 Affinity Capture-Western physical 15051726 ARID1A Affinity Capture-MS physical 16055720 C19orf2 Affinity Capture-MS physical 16055720 EWSR1 Affinity Capture-MS physical 16055720 POLR2A Affinity Capture-MS physical 16055720 POLR2B Affinity Capture-MS physical 16055720 POLR2C Affinity Capture-MS physical 16055720 POLR2E Affinity Capture-MS physical 16055720 SMARCC1 Affinity Capture-MS physical 16055720 SMARCC2 Affinity Capture-MS physical 16055720 SMARCE1 Affinity Capture-MS physical 16055720 NUDT21 Affinity Capture-MS physical 16055720 CPSF6 Affinity Capture-MS physical 16055720 DAZAP1 Affinity Capture-MS physical 16055720 RPAP2 Affinity Capture-MS physical 16055720 HNRNPL Affinity Capture-MS physical 16055720 HNRNPUL1 Affinity Capture-MS physical 16055720 CPSF7 Affinity Capture-MS physical 16055720 PABPC1 Affinity Capture-MS physical 16055720 SF1 Affinity Capture-MS physical 16055720 ITCH Affinity Capture-MS physical 16055720 SPG20 Affinity Capture-MS physical 16055720 RPAP3 Affinity Capture-MS physical 16055720 UBAP2L Affinity Capture-MS physical 16055720 UBAP2 Affinity Capture-MS physical 16055720 WBP2 Affinity Capture-MS physical 16055720 POLR2A Affinity Capture-Western physical 16055720 POLR2A Affinity Capture-Western physical 16055720 CPSF6 Affinity Capture-Western physical 16055720 CPSF6 Affinity Capture-Western physical 16055720 NUDT21 Affinity Capture-Western physical 16055720 NUDT21 Reconstituted Complex physical 16055720 CPSF6 Reconstituted Complex physical 16055720 POLR2A Reconstituted Complex physical 16055720 UBAP2L Reconstituted Complex physical 16055720 SH3GL2 Affinity Capture-Western physical 14684745 HGS Affinity Capture-Western physical 14602072 CBLC Two-hybrid physical 12226085 CBLC Reconstituted Complex physical 12226085 CBLC Affinity Capture-Western physical 12226085 CBLC Affinity Capture-Western physical 12226085 NOTCH1 Affinity Capture-Western physical 10940313 NOTCH1 Affinity Capture-Western physical 10940313 TP63 Affinity Capture-Western physical 16908849 OCLN Affinity Capture-Western physical 19478092 CFLAR Affinity Capture-Western physical 21474069 TP53 Affinity Capture-Western physical 21474069 CFLAR Affinity Capture-Western physical 21474069 TP53 Affinity Capture-Western physical 21474069 UBC Affinity Capture-Western physical 17013377 SNX9 Reconstituted Complex physical 20491914 SNX9 Affinity Capture-Western physical 20491914 SNX9 Biochemical Activity physical 20491914 SNX9 Reconstituted Complex physical 20491914 SNX18 Affinity Capture-Western physical 20491914 BID Affinity Capture-Western physical 20392206 UBC Affinity Capture-Western physical 20484045 RNF11 Affinity Capture-Western physical 20676133 NDFIP2 Affinity Capture-Western physical 20522958 SPG20 Affinity Capture-MS physical 19765186 MAP2K4 Affinity Capture-Western physical 19737936 MAP2K4 Reconstituted Complex physical 19737936 MAP2K4 Biochemical Activity physical 19737936 SRC Affinity Capture-MS physical 16051665 TRPV4 Affinity Capture-Western physical 20650893 CYLD Affinity Capture-Western physical 22057290 CYLD Affinity Capture-Western physical 22057290 CYLD Reconstituted Complex physical 22057290 UBC Affinity Capture-Western physical 19341794 UBC Affinity Capture-Western physical 19341794 CBL Affinity Capture-Western physical 19341794 SH3GLB1 Affinity Capture-Western physical 19341794 USP9X Affinity Capture-Western physical 19341794 SPG20 Affinity Capture-Western physical 19580544 UBC Affinity Capture-Western physical 19343052 NUMB Reconstituted Complex physical 20818436 UBC Affinity Capture-Western physical 20818436 GLI1 Affinity Capture-Western physical 20818436 GLI1 Reconstituted Complex physical 20818436 GLI1 Reconstituted Complex physical 20818436 GLI1 Biochemical Activity physical 20818436 GLI1 Affinity Capture-Western physical 20818436 NUMB Affinity Capture-Western physical 20818436 UBC Affinity Capture-Western physical 19808964 CFLAR Affinity Capture-Western physical 19808964 CFLAR Affinity Capture-Western physical 19808964 TNFRSF10B Affinity Capture-Western physical 19808964 SPG20 Affinity Capture-Western physical 20504295 UBC Affinity Capture-Western physical 20504295 LATS1 Affinity Capture-Western physical 21212414 LATS1 Affinity Capture-Western physical 21212414 LATS1 Reconstituted Complex physical 21212414 LAPTM5 Affinity Capture-Western physical 22009753 LAPTM5 Biochemical Activity physical 22009753 TOLLIP Affinity Capture-MS physical 21903422 UBC Affinity Capture-MS physical 20639865 ARRDC1 Two-hybrid physical 21191027 UBC Affinity Capture-MS physical 21987572