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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for DOT1L (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0016568 chromatin modification IEA GO:0034968 histone lysine methylation IDA cellular_component GO:0005634 nucleus IEA molecular_function GO:0003677 DNA binding IEA GO:0005515 protein binding IPI GO:0008168 methyltransferase activity IEA GO:0016740 transferase activity IEA GO:0018024 histone-lysine N-methyltransferase activity IDA GO:0018024 histone-lysine N-methyltransferase activity IEA

Protein-protein interaction details for DOT1L (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MLLT10 Affinity Capture-Western physical 15851025 MLLT3 Two-hybrid physical 16636056 MLLT3 Reconstituted Complex physical 16636056 MLLT3 Affinity Capture-Western physical 16636056 MLLT3 Affinity Capture-Western physical 16636056 MLLT3 Reconstituted Complex physical 17332896 MLLT6 Two-hybrid physical 19864429 MLLT6 Two-hybrid physical 19864429 MLLT6 Reconstituted Complex physical 19864429 MLLT6 Affinity Capture-Western physical 19864429 SIRT1 Affinity Capture-Western physical 19491102 NPM1 Affinity Capture-MS physical 20431927 HNRNPM Affinity Capture-MS physical 20431927 MLLT3 Affinity Capture-MS physical 20431927 MLLT1 Affinity Capture-MS physical 20431927 MLLT10 Affinity Capture-MS physical 20431927 HIST1H1C Affinity Capture-MS physical 20431927 DDX21 Affinity Capture-MS physical 20431927 HIST1H2BB Affinity Capture-MS physical 20431927 GRWD1 Affinity Capture-MS physical 20431927 HNRNPU Affinity Capture-MS physical 20431927 HIST1H2AA Affinity Capture-MS physical 20431927 THOC4 Affinity Capture-MS physical 20431927 CSDA Affinity Capture-MS physical 20431927 SYNCRIP Affinity Capture-MS physical 20431927 GNL3 Affinity Capture-MS physical 20431927 H1FX Affinity Capture-MS physical 20431927 HIST1H1A Affinity Capture-MS physical 20431927 MLLT3 Affinity Capture-MS physical 20431927 MLLT1 Affinity Capture-MS physical 20431927 NPM1 Affinity Capture-Western physical 20431927 DDX21 Affinity Capture-Western physical 20431927 HNRNPM Affinity Capture-Western physical 20431927 MLLT1 Affinity Capture-Western physical 20431927 SIRT1 Affinity Capture-Western physical 20431927 MLLT1 Affinity Capture-Western physical 20153263 MLLT1 Affinity Capture-Western physical 20153263 MLLT3 Affinity Capture-MS physical 20854876 MLL Affinity Capture-Western physical 20854876 AFF1 Affinity Capture-MS physical 21030982 AFF1 Affinity Capture-Western physical 21030982 HIST2H3C Biochemical Activity physical 21726816