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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CUL4A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0006281 DNA repair IEA GO:0006511 ubiquitin-dependent protein catabolic process IEA GO:0007050 cell cycle arrest TAS GO:0007346 regulation of mitotic cell cycle IEA GO:0008285 negative regulation of cell proliferation TAS GO:0008629 induction of apoptosis by intracellular signals TAS GO:0044419 interspecies interaction between organisms IEA GO:0045750 positive regulation of S phase of mitotic cell cycle IEA GO:0051246 regulation of protein metabolic process IEA cellular_component GO:0031461 cullin-RING ubiquitin ligase complex IEA GO:0031464 Cul4A-RING ubiquitin ligase complex IDA molecular_function GO:0005515 protein binding IPI GO:0031625 ubiquitin protein ligase binding IEA

Protein-protein interaction details for CUL4A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RNF7 Two-hybrid physical 10230407 DET1 Affinity Capture-Western physical 14739464 RFWD2 Affinity Capture-Western physical 14739464 CAND1 Affinity Capture-Western physical 12609982 CAND1 Affinity Capture-MS physical 12609982 RBX1 Affinity Capture-MS physical 12481031 HSPA1A Affinity Capture-MS physical 12481031 HSP90AA1 Affinity Capture-MS physical 12481031 NEDD8 Affinity Capture-MS physical 12481031 TUBA1B Affinity Capture-MS physical 12481031 CDKN1A Affinity Capture-Western physical 18794347 CDKN1A Affinity Capture-Western physical 18794347 RBX1 Two-hybrid physical 10230407 DDB1 Affinity Capture-Western physical 18593899 DDB2 Affinity Capture-Western physical 18593899 RBX1 Affinity Capture-Western physical 18593899 CUL4B Affinity Capture-Western physical 18593899 DDB2 Affinity Capture-Western physical 18593899 DDB1 Affinity Capture-Western physical 18593899 FBXW5 Affinity Capture-Western physical 18381890 NF2 Affinity Capture-Western physical 18332868 NF2 Affinity Capture-Western physical 18332868 SAP130 Affinity Capture-Western physical 18173839 CDKN1B Affinity Capture-Western physical 19056892 COPS5 Affinity Capture-MS physical 19615732 COPS6 Affinity Capture-MS physical 19615732 PTGS2 Affinity Capture-Western physical 17429597 DDB1 Affinity Capture-MS physical 16964240 UBC Affinity Capture-MS physical 16964240 PCNA Affinity Capture-MS physical 16964240 CUL4B Affinity Capture-MS physical 16964240 TRPC4AP Affinity Capture-MS physical 16964240 DET1 Affinity Capture-MS physical 16964240 DDA1 Affinity Capture-MS physical 16964240 NEDD8 Affinity Capture-MS physical 16964240 CRBN Affinity Capture-MS physical 16964240 COPS3 Affinity Capture-MS physical 16964240 COPS4 Affinity Capture-MS physical 16964240 COPS5 Affinity Capture-MS physical 16964240 COPS2 Affinity Capture-MS physical 16964240 COPS8 Affinity Capture-MS physical 16964240 COPS7B Affinity Capture-MS physical 16964240 COPS7A Affinity Capture-MS physical 16964240 COPS6 Affinity Capture-MS physical 16964240 DDB1 Affinity Capture-MS physical 16964240 DDB2 Affinity Capture-MS physical 16964240 DCAF11 Affinity Capture-MS physical 16964240 DCAF5 Affinity Capture-MS physical 16964240 BRWD1 Affinity Capture-MS physical 16964240 PHIP Affinity Capture-MS physical 16964240 DCAF6 Affinity Capture-MS physical 16964240 DCAF12 Affinity Capture-MS physical 16964240 DCAF10 Affinity Capture-MS physical 16964240 DCAF4 Affinity Capture-MS physical 16964240 WDTC1 Affinity Capture-MS physical 16964240 CAND1 Affinity Capture-MS physical 16964240 DDB1 Affinity Capture-MS physical 16949367 VprBP Reconstituted Complex physical 16949367 AMBRA1 Reconstituted Complex physical 16949367 DCAF4 Reconstituted Complex physical 16949367 DCAF6 Reconstituted Complex physical 16949367 DCAF16 Reconstituted Complex physical 16949367 DCAF17 Reconstituted Complex physical 16949367 WDTC1 Reconstituted Complex physical 16949367 DCAF5 Reconstituted Complex physical 16949367 DCAF11 Reconstituted Complex physical 16949367 DCAF8 Reconstituted Complex physical 16949367 DCAF15 Reconstituted Complex physical 16949367 DTL Reconstituted Complex physical 16949367 DDA1 Reconstituted Complex physical 16949367 DDB2 Reconstituted Complex physical 16949367 DET1 Reconstituted Complex physical 16949367 ERCC8 Reconstituted Complex physical 16949367 DDB1 Affinity Capture-MS physical 16678110 NEDD8 Affinity Capture-MS physical 16620772 SKP2 Affinity Capture-Western physical 16537899 CDKN1B Affinity Capture-Western physical 16537899 DDB2 Affinity Capture-Western physical 16473935 DDB1 Affinity Capture-Western physical 16473935 TOR1AIP2 Affinity Capture-MS physical 16964240 COPS3 Affinity Capture-MS physical 16036220 BANF1 Affinity Capture-Western physical 19759913 EMD Affinity Capture-Western physical 19759913 DDB1 Affinity Capture-Western physical 15811626 DDB2 Affinity Capture-Western physical 15811626 DDB2 Affinity Capture-Western physical 17041588 DTL Affinity Capture-Western physical 17041588 WDR26 Affinity Capture-Western physical 17041588 GRWD1 Affinity Capture-Western physical 17041588 RBBP5 Affinity Capture-Western physical 17041588 RFWD2 Affinity Capture-Western physical 17041588 WDR5B Affinity Capture-Western physical 17041588 POC1B Affinity Capture-Western physical 17041588 SNRNP40 Affinity Capture-Western physical 17041588 WDR61 Affinity Capture-Western physical 17041588 WDR76 Affinity Capture-Western physical 17041588 WDR82 Affinity Capture-Western physical 17041588 WDR5 Affinity Capture-Western physical 17041588 TLE2 Affinity Capture-Western physical 17041588 EED Affinity Capture-Western physical 17041588 HIST1H3A Affinity Capture-Western physical 17041588 HIST1H3A Reconstituted Complex physical 17041588 KEAP1 Affinity Capture-Western physical 15572695 DDB1 Affinity Capture-Western physical 15448697 CAND1 Affinity Capture-Western physical 15448697 DDB1 Affinity Capture-Western physical 15448697 DDB1 Two-hybrid physical 15448697 RBX1 Two-hybrid physical 15448697 CDT1 Affinity Capture-Western physical 15448697 CDT1 Biochemical Activity physical 15448697 RBX1 Affinity Capture-Western physical 11861641 DDB2 Affinity Capture-Western physical 11564859 CHEK1 Affinity Capture-Western physical 19276361 COMMD1 Reconstituted Complex physical 21778237 COMMD1 Reconstituted Complex physical 21778237 DNMT3B Affinity Capture-Western physical 20847044 DDB1 Reconstituted Complex physical 20870715 VprBP Reconstituted Complex physical 20870715 UBXN7 Affinity Capture-MS physical 18775313 NEDD8 Affinity Capture-MS physical 18274552 RBX1 Affinity Capture-Western physical 19287380 DDB1 Affinity Capture-Western physical 19287380 MYC Affinity Capture-Western physical 20551172 TRPC4AP Affinity Capture-Western physical 20551172 KAT2A Affinity Capture-Western physical 21987584 KAT2A Biochemical Activity physical 21987584 CRBN Affinity Capture-Western physical 20223979 DDB2 Affinity Capture-Western physical 20368362 RASSF1 Affinity Capture-Western physical 21205828 RASSF1 Affinity Capture-Western physical 21205828 DDB1 Co-crystal Structure physical 22118460 DDB2 Affinity Capture-Western physical 22118460 RAG1 Affinity Capture-Western physical 22157821 UBC Affinity Capture-MS physical 18781797 CAND1 Affinity Capture-Western physical 21249194 UBC Affinity Capture-MS physical 21987572 SALL2 Reconstituted Complex physical 21228219