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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SHANK3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001838 embryonic epithelial tube formation IEA GO:0021773 striatal medium spiny neuron differentiation ISS GO:0035176 social behavior IEA GO:0035176 social behavior ISS GO:0035641 locomotory exploration behavior ISS GO:0045794 negative regulation of cell volume ISS GO:0048170 positive regulation of long-term neuronal synaptic plasticity IEA GO:0048170 positive regulation of long-term neuronal synaptic plasticity ISS GO:0048854 brain morphogenesis ISS GO:0051259 protein oligomerization IEA GO:0051835 positive regulation of synapse structural plasticity IEA GO:0051835 positive regulation of synapse structural plasticity ISS GO:0051968 positive regulation of synaptic transmission, glutamatergic ISS GO:0060997 dendritic spine morphogenesis IEA GO:0060997 dendritic spine morphogenesis ISS GO:0071625 vocalization behavior IEA GO:0071625 vocalization behavior ISS GO:0097107 postsynaptic density assembly ISS GO:2000463 positive regulation of excitatory postsynaptic membrane potential ISS GO:2000822 regulation of behavioral fear response ISS GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS cellular_component GO:0005737 cytoplasm IEA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane ISS GO:0014069 postsynaptic density IEA GO:0014069 postsynaptic density ISS GO:0030054 cell junction IEA GO:0044309 neuron spine IEA GO:0044309 neuron spine ISS GO:0045202 synapse IEA GO:0045211 postsynaptic membrane IEA molecular_function GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IEA GO:0008022 protein C-terminus binding ISS GO:0008270 zinc ion binding IEA GO:0017124 SH3 domain binding IEA GO:0030160 GKAP/Homer scaffold activity ISS GO:0035255 ionotropic glutamate receptor binding IEA GO:0035255 ionotropic glutamate receptor binding ISS GO:0043621 protein self-association IEA GO:0097110 scaffold protein binding ISS

Protein-protein interaction details for SHANK3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ARHGEF7 Two-hybrid physical 12626503 ARHGEF7 Affinity Capture-Western physical 12626503 DLGAP1 Two-hybrid physical 10527873 DLGAP2 Two-hybrid physical 10527873 DLGAP3 Two-hybrid physical 10527873 DLGAP4 Two-hybrid physical 10527873 SPTAN1 Two-hybrid physical 11509555