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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for SPHK1 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0001568
blood vessel development
IEA
GO:0006457
protein folding
TAS
GO:0006665
sphingolipid metabolic process
TAS
GO:0006670
sphingosine metabolic process
IDA
GO:0006916
anti-apoptosis
TAS
GO:0006954
inflammatory response
IEA
GO:0007165
signal transduction
TAS
GO:0007205
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
IEA
GO:0007420
brain development
IEA
GO:0010803
regulation of tumor necrosis factor-mediated signaling pathway
IDA
GO:0019722
calcium-mediated signaling
IDA
GO:0030307
positive regulation of cell growth
IDA
GO:0030335
positive regulation of cell migration
IDA
GO:0031398
positive regulation of protein ubiquitination
IDA
GO:0032651
regulation of interleukin-1 beta production
IEA
GO:0035556
intracellular signal transduction
TAS
GO:0042346
positive regulation of NF-kappaB import into nucleus
IMP
GO:0043066
negative regulation of apoptosis
IDA
GO:0044267
cellular protein metabolic process
TAS
GO:0045766
positive regulation of angiogenesis
IDA
GO:0045931
positive regulation of mitotic cell cycle
IDA
GO:0045987
positive regulation of smooth muscle contraction
IDA
GO:0046521
sphingoid catabolic process
NAS
GO:0048146
positive regulation of fibroblast proliferation
IDA
GO:0051084
'de novo' posttranslational protein folding
TAS
GO:0051092
positive regulation of NF-kappaB transcription factor activity
IMP
cellular_component
GO:0005624
membrane fraction
IDA
GO:0005624
membrane fraction
TAS
GO:0005625
soluble fraction
IDA
GO:0005634
nucleus
IEA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
TAS
GO:0005886
plasma membrane
IDA
molecular_function
GO:0000166
nucleotide binding
IEA
GO:0000287
magnesium ion binding
IDA
GO:0000287
magnesium ion binding
ISS
GO:0003677
DNA binding
IDA
GO:0004143
diacylglycerol kinase activity
IEA
GO:0005515
protein binding
IPI
GO:0005516
calmodulin binding
IDA
GO:0005524
ATP binding
IDA
GO:0008481
sphinganine kinase activity
IDA
GO:0016740
transferase activity
IEA
GO:0017050
D-erythro-sphingosine kinase activity
IDA
GO:0051721
protein phosphatase 2A binding
IPI
Protein-protein interaction details for SPHK1 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
RPS6KC1
Affinity Capture-Western
physical
12077123
TRAF2
Affinity Capture-Western
physical
11777919
TRAF2
Reconstituted Complex
physical
11777919
EP300
Biochemical Activity
physical
22227192
UBC
Biochemical Activity
physical
22227192