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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SPHK1 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001568blood vessel developmentIEA
GO:0006457protein foldingTAS
GO:0006665sphingolipid metabolic processTAS
GO:0006670sphingosine metabolic processIDA
GO:0006916anti-apoptosisTAS
GO:0006954inflammatory responseIEA
GO:0007165signal transductionTAS
GO:0007205activation of protein kinase C activity by G-protein coupled receptor protein signaling pathwayIEA
GO:0007420brain developmentIEA
GO:0010803regulation of tumor necrosis factor-mediated signaling pathwayIDA
GO:0019722calcium-mediated signalingIDA
GO:0030307positive regulation of cell growthIDA
GO:0030335positive regulation of cell migrationIDA
GO:0031398positive regulation of protein ubiquitinationIDA
GO:0032651regulation of interleukin-1 beta productionIEA
GO:0035556intracellular signal transductionTAS
GO:0042346positive regulation of NF-kappaB import into nucleusIMP
GO:0043066negative regulation of apoptosisIDA
GO:0044267cellular protein metabolic processTAS
GO:0045766positive regulation of angiogenesisIDA
GO:0045931positive regulation of mitotic cell cycleIDA
GO:0045987positive regulation of smooth muscle contractionIDA
GO:0046521sphingoid catabolic processNAS
GO:0048146positive regulation of fibroblast proliferationIDA
GO:0051084'de novo' posttranslational protein foldingTAS
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
cellular_component
GO:0005624membrane fractionIDA
GO:0005624membrane fractionTAS
GO:0005625soluble fractionIDA
GO:0005634nucleusIEA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
molecular_function
GO:0000166nucleotide bindingIEA
GO:0000287magnesium ion bindingIDA
GO:0000287magnesium ion bindingISS
GO:0003677DNA bindingIDA
GO:0004143diacylglycerol kinase activityIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIDA
GO:0005524ATP bindingIDA
GO:0008481sphinganine kinase activityIDA
GO:0016740transferase activityIEA
GO:0017050D-erythro-sphingosine kinase activityIDA
GO:0051721protein phosphatase 2A bindingIPI

Protein-protein interaction details for SPHK1 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
RPS6KC1Affinity Capture-Westernphysical12077123
TRAF2Affinity Capture-Westernphysical11777919
TRAF2Reconstituted Complexphysical11777919
EP300Biochemical Activityphysical22227192
UBCBiochemical Activityphysical22227192