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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CD3E (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002669 positive regulation of T cell anergy IEA GO:0006461 protein complex assembly NAS GO:0007166 cell surface receptor linked signaling pathway IEA GO:0007166 cell surface receptor linked signaling pathway NAS GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS GO:0007172 signal complex assembly TAS GO:0007186 G-protein coupled receptor protein signaling pathway TAS GO:0007584 response to nutrient IEA GO:0008624 induction of apoptosis by extracellular signals IEA GO:0031295 T cell costimulation TAS GO:0032729 positive regulation of interferon-gamma production IEA GO:0032753 positive regulation of interleukin-4 production IEA GO:0033077 T cell differentiation in thymus IEA GO:0042102 positive regulation of T cell proliferation IMP GO:0042110 T cell activation NAS GO:0042981 regulation of apoptosis NAS GO:0045060 negative thymic T cell selection IEA GO:0045086 positive regulation of interleukin-2 biosynthetic process IEA GO:0045879 negative regulation of smoothened signaling pathway IEA GO:0046641 positive regulation of alpha-beta T cell proliferation IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050776 regulation of immune response TAS GO:0050850 positive regulation of calcium-mediated signaling IEA GO:0050852 T cell receptor signaling pathway TAS cellular_component GO:0001772 immunological synapse IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane NAS GO:0009897 external side of plasma membrane IDA GO:0016020 membrane IEA GO:0042101 T cell receptor complex IDA GO:0042101 T cell receptor complex NAS GO:0042105 alpha-beta T cell receptor complex IEA molecular_function GO:0004872 receptor activity IEA GO:0004888 transmembrane signaling receptor activity IEA GO:0004888 transmembrane signaling receptor activity NAS GO:0005057 receptor signaling protein activity TAS GO:0017124 SH3 domain binding IPI GO:0019901 protein kinase binding NAS GO:0030159 receptor signaling complex scaffold activity NAS GO:0042608 T cell receptor binding NAS GO:0046982 protein heterodimerization activity IPI

Protein-protein interaction details for CD3E (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NCL Reconstituted Complex physical 11115514 PIK3R1 Affinity Capture-Western physical 9312149 ZAP70 Reconstituted Complex physical 7761456 SYK Reconstituted Complex physical 7761456 CD3EAP Affinity Capture-Western physical 10373416 CD3EAP Reconstituted Complex physical 10373416 NCK2 Reconstituted Complex physical 12110186 NCK2 Reconstituted Complex physical 12110186 NCK1 Reconstituted Complex physical 12110186 NCK2 Two-hybrid physical 12110186 JAK3 Affinity Capture-Western physical 11349123 CD3G Affinity Capture-Western physical 9582308 TOP2B Affinity Capture-Western physical 8626450 TOP2B Reconstituted Complex physical 8626450