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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SLIT2 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001657ureteric bud developmentIMP
GO:0001933negative regulation of protein phosphorylationIDA
GO:0002042cell migration involved in sprouting angiogenesisIMP
GO:0002689negative regulation of leukocyte chemotaxisIDA
GO:0007275multicellular organismal developmentIEA
GO:0007399nervous system developmentIEA
GO:0007411axon guidanceIDA
GO:0007411axon guidanceTAS
GO:0008045motor axon guidanceIDA
GO:0010593negative regulation of lamellipodium assemblyIDA
GO:0010596negative regulation of endothelial cell migrationIDA
GO:0014912negative regulation of smooth muscle cell migrationIDA
GO:0021834chemorepulsion involved in embryonic olfactory bulb interneuron migrationIDA
GO:0021836chemorepulsion involved in postnatal olfactory bulb interneuron migrationIDA
GO:0021972corticospinal neuron axon guidance through spinal cordIMP
GO:0030154cell differentiationIEA
GO:0030308negative regulation of cell growthIMP
GO:0030336negative regulation of cell migrationIDA
GO:0030336negative regulation of cell migrationIMP
GO:0030837negative regulation of actin filament polymerizationIDA
GO:0031290retinal ganglion cell axon guidanceIDA
GO:0032870cellular response to hormone stimulusIEP
GO:0035385Roundabout signaling pathwayIC
GO:0035385Roundabout signaling pathwayIMP
GO:0043065positive regulation of apoptosisIMP
GO:0043116negative regulation of vascular permeabilityIDA
GO:0048754branching morphogenesis of a tubeIDA
GO:0048754branching morphogenesis of a tubeIMP
GO:0048846axon extension involved in axon guidanceIDA
GO:0050772positive regulation of axonogenesisTAS
GO:0050919negative chemotaxisIDA
GO:0050919negative chemotaxisIMP
GO:0050929induction of negative chemotaxisIDA
GO:0051058negative regulation of small GTPase mediated signal transductionIDA
GO:0051414response to cortisol stimulusIEP
GO:0061364apoptosis involved in luteolysisIEP
GO:0070100negative regulation of chemokine-mediated signaling pathwayIMP
GO:0071504cellular response to heparinIDA
GO:0071672negative regulation of smooth muscle cell chemotaxisIDA
GO:0071676negative regulation of mononuclear cell migrationIDA
GO:0090024negative regulation of neutrophil chemotaxisIDA
GO:0090260negative regulation of retinal ganglion cell axon guidanceIDA
GO:0090288negative regulation of cellular response to growth factor stimulusIDA
cellular_component
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005737cytoplasmIDA
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIDA
GO:0016020membraneNAS
molecular_function
GO:0005095GTPase inhibitor activityIDA
GO:0005509calcium ion bindingNAS
GO:0005515protein bindingIPI
GO:0008201heparin bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0043237laminin-1 bindingIDA
GO:0043394proteoglycan bindingIPI
GO:0048495Roundabout bindingIPI

Protein-protein interaction details for SLIT2 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
ROBO4Affinity Capture-Westernphysical12941633
GPC1Affinity Capture-Westernphysical11375980
GPC1Reconstituted Complexphysical11375980
MYCAffinity Capture-MSphysical17314511