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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CD74 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity IEA GO:0001516 prostaglandin biosynthetic process IDA GO:0001961 positive regulation of cytokine-mediated signaling pathway IMP GO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA GO:0002792 negative regulation of peptide secretion IDA GO:0002830 positive regulation of type 2 immune response IEA GO:0002906 negative regulation of mature B cell apoptosis IEA GO:0006461 protein complex assembly ISS GO:0006886 intracellular protein transport IEA GO:0006886 intracellular protein transport ISS GO:0006952 defense response IEA GO:0006955 immune response IEA GO:0007165 signal transduction IDA GO:0008283 cell proliferation IDA GO:0016064 immunoglobulin mediated immune response ISS GO:0019221 cytokine-mediated signaling pathway IDA GO:0019882 antigen processing and presentation IEA GO:0019883 antigen processing and presentation of endogenous antigen NAS GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA GO:0030890 positive regulation of B cell proliferation IMP GO:0035691 macrophage migration inhibitory factor signaling pathway IEA GO:0043030 regulation of macrophage activation NAS GO:0043066 negative regulation of apoptosis IDA GO:0043066 negative regulation of apoptosis IMP GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA GO:0045058 T cell selection NAS GO:0045059 positive thymic T cell selection IEA GO:0045060 negative thymic T cell selection IEA GO:0045581 negative regulation of T cell differentiation IEA GO:0045582 positive regulation of T cell differentiation IEA GO:0048146 positive regulation of fibroblast proliferation IMP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA GO:0051085 chaperone mediated protein folding requiring cofactor IEA GO:0060907 positive regulation of macrophage cytokine production ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP GO:0090023 positive regulation of neutrophil chemotaxis ISS GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production ISS cellular_component GO:0005622 intracellular ISS GO:0005622 intracellular TAS GO:0005764 lysosome IEA GO:0005771 multivesicular body IEA GO:0005773 vacuole IDA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005794 Golgi apparatus IEA GO:0005886 plasma membrane IEA GO:0009897 external side of plasma membrane IEA GO:0009986 cell surface IDA GO:0016020 membrane IEA GO:0016021 integral to membrane IDA GO:0035692 macrophage migration inhibitory factor receptor complex IEA GO:0035693 NOS2-CD74 complex IEA GO:0042613 MHC class II protein complex ISS GO:0043235 receptor complex IDA molecular_function GO:0001540 beta-amyloid binding IPI GO:0004896 cytokine receptor activity IDA GO:0019955 cytokine binding IPI GO:0042289 MHC class II protein binding IEA GO:0042289 MHC class II protein binding ISS GO:0042289 MHC class II protein binding NAS GO:0042802 identical protein binding TAS GO:0050998 nitric-oxide synthase binding IEA

Protein-protein interaction details for CD74 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MIF Reconstituted Complex physical 12782713 MIF Affinity Capture-Western physical 12782713 CD74 Co-purification physical 2391366 UBC Affinity Capture-Western physical 21059907