| Entrez gene ID | | 1026 |
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| Official gene symbol | | CDKN1A |
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| Full name | | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
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| Aliases | | ,CAP20,CDKN1,CIP1,MDA-6,P21,SDI1,WAF1,p21CIP1, |
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| Gene summary | | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 6 Locus: 6p21.2 |
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| Gene position | | 36646459 - 36655109 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 8651 bp |
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| Gene sequence |
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| OMIM ID | | 116899 |
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