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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDKN1A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000079 regulation of cyclin-dependent protein kinase activity TAS GO:0000080 G1 phase of mitotic cell cycle TAS GO:0000082 G1/S transition of mitotic cell cycle IDA GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000084 S phase of mitotic cell cycle TAS GO:0000086 G2/M transition of mitotic cell cycle IMP GO:0000278 mitotic cell cycle TAS GO:0006974 response to DNA damage stimulus IMP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0007049 cell cycle EXP GO:0007050 cell cycle arrest IDA GO:0007050 cell cycle arrest IMP GO:0007265 Ras protein signal transduction IEP GO:0007346 regulation of mitotic cell cycle IEA GO:0008285 negative regulation of cell proliferation IDA GO:0008285 negative regulation of cell proliferation IMP GO:0008629 induction of apoptosis by intracellular signals TAS GO:0009411 response to UV IEA GO:0009636 response to toxin IEA GO:0010243 response to organic nitrogen IEA GO:0010629 negative regulation of gene expression IEA GO:0014070 response to organic cyclic compound IEA GO:0016310 phosphorylation TAS GO:0030308 negative regulation of cell growth IDA GO:0030890 positive regulation of B cell proliferation IEA GO:0031100 organ regeneration IEA GO:0031668 cellular response to extracellular stimulus IMP GO:0033158 regulation of protein import into nucleus, translocation IEA GO:0042326 negative regulation of phosphorylation IDA GO:0042493 response to drug IEA GO:0043066 negative regulation of apoptosis IEA GO:0043068 positive regulation of programmed cell death IEA GO:0045736 negative regulation of cyclin-dependent protein kinase activity IEA GO:0045768 positive regulation of anti-apoptosis IEA GO:0046685 response to arsenic-containing substance IEA GO:0048146 positive regulation of fibroblast proliferation IMP GO:0051412 response to corticosterone stimulus IEA GO:0055093 response to hyperoxia IEA GO:0071479 cellular response to ionizing radiation IMP GO:0090398 cellular senescence IMP GO:0090400 stress-induced premature senescence TAS GO:2000278 regulation of DNA biosynthetic process IEA GO:2000379 positive regulation of reactive oxygen species metabolic process IMP cellular_component GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0070557 PCNA-p21 complex IDA molecular_function GO:0004693 cyclin-dependent protein kinase activity EXP GO:0004693 cyclin-dependent protein kinase activity TAS GO:0004860 protein kinase inhibitor activity IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity IEA GO:0005515 protein binding IPI GO:0016301 kinase activity TAS GO:0019912 cyclin-dependent protein kinase activating kinase activity IDA GO:0030332 cyclin binding IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for CDKN1A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TSG101 Two-hybrid physical 11943869 TEX11 Two-hybrid physical 16189514 CCND2 Two-hybrid physical 16189514 CCDC85B Two-hybrid physical 16189514 CCND3 Two-hybrid physical 16189514 PCNA Two-hybrid physical 16189514 GADD45A Affinity Capture-Western physical 10912791 GADD45A Reconstituted Complex physical 10912791 CHEK1 Affinity Capture-Western physical 11896572 CDK2 Affinity Capture-Western physical 10878006 GADD45G Two-hybrid physical 11022036 GADD45G Reconstituted Complex physical 11022036 GADD45G Affinity Capture-Western physical 11022036 GADD45A Affinity Capture-Western physical 10973963 TP53 Affinity Capture-Western physical 11896572 GADD45A Affinity Capture-Western physical 10973963 BCCIP Two-hybrid physical 10878006 BCCIP Reconstituted Complex physical 10878006 CCNA2 Affinity Capture-Western physical 12947099 PARP1 Reconstituted Complex physical 12930846 PCNA Reconstituted Complex physical 12930846 CDK2 Affinity Capture-Western physical 12839982 CCNE1 Affinity Capture-Western physical 12839982 CCNE1 Affinity Capture-Western physical 12839982 CDK2 Reconstituted Complex physical 12839982 GET4 Two-hybrid physical 16169070 GNB2L1 Two-hybrid physical 16169070 HDAC11 Two-hybrid physical 16169070 RAB1A Two-hybrid physical 16169070 CSNK2B Reconstituted Complex physical 10679299 HERC5 Reconstituted Complex physical 10581175 PCNA Reconstituted Complex physical 9465025 CDK2 Affinity Capture-Western physical 12417722 PCNA Reconstituted Complex physical 8861969 PCNA Reconstituted Complex physical 9545252 MAP3K5 Affinity Capture-Western physical 12820963 CDK2 Two-hybrid physical 8242751 CDK2 Reconstituted Complex physical 8242751 GADD45G Affinity Capture-Western physical 10455148 TSG101 Affinity Capture-Western physical 11943869 PCNA Co-crystal Structure physical 8861913 CIZ1 Two-hybrid physical 10529385 CIZ1 Affinity Capture-Western physical 10529385 CIZ1 Affinity Capture-Western physical 10529385 TK1 Affinity Capture-Western physical 11389691 TK1 Reconstituted Complex physical 11389691 PIM1 Biochemical Activity physical 12431783 PIM1 Reconstituted Complex physical 12431783 STAT3 Affinity Capture-Western physical 10764767 CCND1 Reconstituted Complex physical 8657154 SET Reconstituted Complex physical 12407107 PSMA3 Reconstituted Complex physical 11350925 PCNA Reconstituted Complex physical 11350925 CDK2 Affinity Capture-Western physical 9858587 CUL4A Affinity Capture-Western physical 18794347 DDB1 Affinity Capture-Western physical 18794347 CUL4A Affinity Capture-Western physical 18794347 DDB1 Affinity Capture-Western physical 18794347 DTL Affinity Capture-Western physical 18794347 DTL Biochemical Activity physical 18794347 PCNA Two-hybrid physical 11313979 PCNA Affinity Capture-Western physical 11313979 BCCIP Affinity Capture-Western physical 10878006 CDC20 Affinity Capture-Western physical 17679094 SKP2 Affinity Capture-Western physical 17679094 CDC27 Affinity Capture-Western physical 17679094 CCNA2 Affinity Capture-Western physical 17679094 CCNB1 Affinity Capture-Western physical 17679094 CDK1 Affinity Capture-Western physical 17679094 PSME3 Affinity Capture-Western physical 17588519 PSME3 Affinity Capture-Western physical 17588519 PCNA Affinity Capture-Western physical 17588519 PCNA Affinity Capture-Western physical 17588519 UBC Affinity Capture-Western physical 17477906 UBC Reconstituted Complex physical 17477906 SKP2 Affinity Capture-Western physical 17477906 HDAC1 Reconstituted Complex physical 20154723 HDAC1 Affinity Capture-Western physical 20154723 CDK2 Affinity Capture-Western physical 20102411 CDK4 Affinity Capture-Western physical 20102411 CDK6 Affinity Capture-Western physical 20102411 MAPK8 Affinity Capture-Western physical 20102411 JUN Affinity Capture-Western physical 20102411 JUN Affinity Capture-Western physical 20102411 MAPK8 Affinity Capture-Western physical 20102411 UBC Affinity Capture-Western physical 16262255 PCNA Affinity Capture-Western physical 17115032 CCND1 Affinity Capture-Western physical 15695403 CDK4 Affinity Capture-Western physical 15695403 DTL Affinity Capture-Western physical 18703516 DDB1 Affinity Capture-Western physical 18703516 GAPDH Affinity Capture-MS physical 16474839 SET Reconstituted Complex physical 16474839 PCNA Reconstituted Complex physical 16474839 GAPDH Reconstituted Complex physical 16474839 MGMT Affinity Capture-Western physical 16226712 UBC Affinity Capture-Western physical 14761977 MDM2 Affinity Capture-Western physical 14761977 MDM2 Affinity Capture-Western physical 14761977 MDM2 Reconstituted Complex physical 14761977 PCNA Reconstituted Complex physical 16082198 CCNB1 Reconstituted Complex physical 16082198 HDAC1 Reconstituted Complex physical 16082198 HDAC4 Reconstituted Complex physical 16082198 HDAC6 Reconstituted Complex physical 16082198 CCND1 Reconstituted Complex physical 16082198 HDAC2 Reconstituted Complex physical 16082198 UBC Affinity Capture-Western physical 12052868 E2F1 Co-localization physical 15964998 ESR1 Reconstituted Complex physical 15743834 CREBBP Affinity Capture-Western physical 15743834 RNF144B Affinity Capture-Western physical 12853982 RNF144B Reconstituted Complex physical 12853982 RNF144B Affinity Capture-Western physical 12853982 CDK2 Affinity Capture-Western physical 15647383 CDK2 Affinity Capture-Western physical 15557281 EP300 Reconstituted Complex physical 18263614 EP300 Affinity Capture-Western physical 18263614 UBC Affinity Capture-Western physical 10837373 CCNE1 Affinity Capture-Western physical 17293600 CDK2 Affinity Capture-Western physical 20587660 PARP1 Reconstituted Complex physical 20303835 PARP1 Affinity Capture-Western physical 20303835 PARP1 Affinity Capture-Western physical 20302655 PCNA Affinity Capture-Western physical 19704162 UBC Affinity Capture-Western physical 17292858 CCND1 Affinity Capture-MS physical 17081987 MDM4 Affinity Capture-Western physical 18086887 MDM4 Affinity Capture-Western physical 18086887 MDM4 Reconstituted Complex physical 18086887 MDM4 Reconstituted Complex physical 18086887 UBC Affinity Capture-Western physical 18086887 PSMC5 Co-fractionation physical 18086887 PCNA Co-fractionation physical 18086887 MDM4 Co-fractionation physical 18086887 PSMD2 Co-fractionation physical 18086887 PSMD2 Affinity Capture-Western physical 18086887 PCNA Affinity Capture-Western physical 19895794 SKP2 Affinity Capture-Western physical 19686743 UBC Affinity Capture-Western physical 19686743 DTL Affinity Capture-Western physical 20606006 DTL Reconstituted Complex physical 20606006 PCNA Affinity Capture-Western physical 20606006 UBC Affinity Capture-Western physical 20606006 UBC Reconstituted Complex physical 20606006 CDK4 Affinity Capture-Western physical 17556661 CCND1 Affinity Capture-Western physical 17556661 CDK4 Affinity Capture-Western physical 17556661 CCND1 Affinity Capture-Western physical 17556661 NCOR1 Affinity Capture-RNA physical 21088000 NCOR2 Affinity Capture-RNA physical 21088000 POLR2A Affinity Capture-RNA physical 21088000 VDR Affinity Capture-RNA physical 21088000 CDC42 Reconstituted Complex physical 18057010 IKBKG Two-hybrid physical 19609363 OPTN Two-hybrid physical 19609363 OPTN Affinity Capture-Western physical 19609363 OPTN Affinity Capture-Western physical 19609363 NPM1 Affinity Capture-Western physical 19221506 NPM1 Affinity Capture-Western physical 19221506 NPM1 Reconstituted Complex physical 19221506 NPM1 Co-localization physical 19221506 UBC Affinity Capture-Western physical 19221506 MDM4 Affinity Capture-Western physical 21148311 MDM4 Affinity Capture-Western physical 21148311 SPRED1 Two-hybrid physical 21900206 ATXN3 Two-hybrid physical 21900206 ATP6V1A Two-hybrid physical 21900206 HMGXB3 Two-hybrid physical 21900206 TP53 Two-hybrid physical 21900206 CSAD Two-hybrid physical 21900206 S100A8 Two-hybrid physical 21900206 CPNE6 Two-hybrid physical 21900206 GNB2 Two-hybrid physical 21900206 EXT2 Two-hybrid physical 21900206 SDF4 Two-hybrid physical 21900206 FLAD1 Two-hybrid physical 21900206 CPNE2 Two-hybrid physical 21900206 OTUB1 Two-hybrid physical 21900206 HADHB Two-hybrid physical 21900206 WIZ Two-hybrid physical 21900206 TAF5L Two-hybrid physical 21900206 CCT7 Two-hybrid physical 21900206 BAT3 Two-hybrid physical 21900206 UBE2D1 Two-hybrid physical 21900206 C7orf64 Two-hybrid physical 21900206 GDF9 Two-hybrid physical 21900206 DEAF1 Two-hybrid physical 21900206 ZBTB48 Two-hybrid physical 21900206 ZBTB16 Two-hybrid physical 21900206 TUBA1A Two-hybrid physical 21900206 KLHL23 Two-hybrid physical 21900206 F13A1 Two-hybrid physical 21900206 SUMO3 Two-hybrid physical 21900206 VIM Two-hybrid physical 21900206 PDHB Two-hybrid physical 21900206 TMSB4X Two-hybrid physical 21900206 DDAH2 Two-hybrid physical 21900206 ADAMTS10 Two-hybrid physical 21900206 WDR73 Two-hybrid physical 21900206 ALAS1 Two-hybrid physical 21900206 TLE1 Two-hybrid physical 21900206 TRMT2A Two-hybrid physical 21900206 ACTB Two-hybrid physical 21900206 COPS6 Two-hybrid physical 21900206 USP4 Two-hybrid physical 21900206 RPS2 Two-hybrid physical 21900206 CTSB Two-hybrid physical 21900206 A2M Two-hybrid physical 21900206 MED31 Two-hybrid physical 21900206 CENPB Two-hybrid physical 21900206 SP110 Two-hybrid physical 21900206 A1BG Two-hybrid physical 21900206 COL4A5 Two-hybrid physical 21900206 RAI1 Two-hybrid physical 21900206 ATP5B Two-hybrid physical 21900206 DYNC1I1 Two-hybrid physical 21900206 EEF1A1 Two-hybrid physical 21900206 FBN3 Two-hybrid physical 21900206 NPRL2 Two-hybrid physical 21900206 APLP1 Two-hybrid physical 21900206 INPP5K Two-hybrid physical 21900206 UNC119 Two-hybrid physical 21900206 CELF3 Two-hybrid physical 21900206 GNB5 Two-hybrid physical 21900206 MSH2 Two-hybrid physical 21900206 C1orf103 Two-hybrid physical 21900206 ANGPT2 Two-hybrid physical 21900206 TUBB3 Two-hybrid physical 21900206 CHGB Two-hybrid physical 21900206 ZNF431 Two-hybrid physical 21900206 PDE4DIP Two-hybrid physical 21900206 ACTL6B Two-hybrid physical 21900206 PKM2 Two-hybrid physical 21900206 NGFR Two-hybrid physical 21900206 DOCK7 Two-hybrid physical 21900206 QARS Two-hybrid physical 21900206 ING5 Two-hybrid physical 21900206 ZNF135 Two-hybrid physical 21900206 MLL4 Two-hybrid physical 21900206 TUBB2B Two-hybrid physical 21900206 FGB Two-hybrid physical 21900206 RBBP4 Two-hybrid physical 21900206 HOXD8 Two-hybrid physical 21900206 CLEC3B Two-hybrid physical 21900206 NRBP1 Two-hybrid physical 21900206 FAF1 Two-hybrid physical 21900206 SETDB1 Two-hybrid physical 21900206 ESR1 Reconstituted Complex physical 17911387 ESR1 Reconstituted Complex physical 17911387 PCNA Affinity Capture-Western physical 11559705 CDK1 Affinity Capture-Western physical 11559705 CCNB1 Affinity Capture-Western physical 11559705 PCNA Affinity Capture-Western physical 11559705 PCNA Affinity Capture-Western physical 11254741 NFE2L2 Affinity Capture-Western physical 19560419 PCNA Affinity Capture-Western physical 21415862 PCNA Affinity Capture-Western physical 20605778 PCNA Affinity Capture-Western physical 20605778 PCNA Protein-peptide physical 15576034 FKBPL Reconstituted Complex physical 15664193 FKBPL Affinity Capture-Western physical 15664193 FKBPL Affinity Capture-Western physical 15664193 HSP90AA1 Affinity Capture-Western physical 15664193