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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPARGC1A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10891
Official gene symbolPPARGC1A
Full nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Aliases,LEM6,PGC-1(alpha),PGC-1v,PGC1,PGC1A,PPARGC1,
Gene summaryThe protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq]
LocationChromosome: 4   Locus: 4p15.1
Gene position23891700 - 23793644  Map Viewer
Gene orientationminus
Gene size98057 bp
Gene sequence
OMIM ID604517