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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PPARGC1A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001659 temperature homeostasis TAS GO:0001678 cellular glucose homeostasis NAS GO:0006094 gluconeogenesis NAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006397 mRNA processing TAS GO:0006461 protein complex assembly TAS GO:0007005 mitochondrion organization NAS GO:0007586 digestion TAS GO:0008380 RNA splicing TAS GO:0010941 regulation of cell death IDA GO:0014850 response to muscle activity ISS GO:0019395 fatty acid oxidation NAS GO:0022904 respiratory electron transport chain IEA GO:0030521 androgen receptor signaling pathway NAS GO:0034599 cellular response to oxidative stress IEA GO:0035066 positive regulation of histone acetylation TAS GO:0042594 response to starvation NAS GO:0043524 negative regulation of neuron apoptosis IEA GO:0045333 cellular respiration TAS GO:0045722 positive regulation of gluconeogenesis TAS GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent NAS GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0046321 positive regulation of fatty acid oxidation TAS GO:0050821 protein stabilization TAS GO:0050873 brown fat cell differentiation TAS GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA GO:0070997 neuron death IDA cellular_component GO:0005634 nucleus TAS GO:0005665 DNA-directed RNA polymerase II, core complex TAS GO:0005829 cytosol IEA molecular_function GO:0000166 nucleotide binding IEA GO:0001104 RNA polymerase II transcription cofactor activity TAS GO:0003677 DNA binding TAS GO:0003713 transcription coactivator activity IDA GO:0003723 RNA binding TAS GO:0004872 receptor activity IEA GO:0005515 protein binding IPI GO:0008134 transcription factor binding TAS GO:0016922 ligand-dependent nuclear receptor binding IPI GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA GO:0050681 androgen receptor binding NAS

Protein-protein interaction details for PPARGC1A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NR1H4 Reconstituted Complex physical 14729567 NR1H4 Affinity Capture-Western physical 14729567 MED1 Affinity Capture-Western physical 14636573 MED16 Affinity Capture-Western physical 14636573 MED17 Affinity Capture-Western physical 14636573 MED21 Affinity Capture-Western physical 14636573 MED12 Affinity Capture-Western physical 14636573 MED14 Affinity Capture-Western physical 14636573 MED20 Affinity Capture-Western physical 14636573 MED1 Reconstituted Complex physical 14636573 MED12 Reconstituted Complex physical 14636573 MED14 Reconstituted Complex physical 14636573 MED17 Reconstituted Complex physical 14636573 MED1 Reconstituted Complex physical 14636573 PPARG Reconstituted Complex physical 14636573 PPARG Reconstituted Complex physical 14636573 HCFC1 Affinity Capture-Western physical 11733490 ESR1 Reconstituted Complex physical 10748020 THRB Reconstituted Complex physical 11751919 THRB Affinity Capture-Western physical 11751919 NRF1 Reconstituted Complex physical 10412986 NRF1 Affinity Capture-Western physical 10412986 SRSF5 Affinity Capture-Western physical 10983978 SRSF6 Affinity Capture-Western physical 10983978 SRSF4 Affinity Capture-Western physical 10983978 SRSF2 Affinity Capture-Western physical 10983978 PPARA Reconstituted Complex physical 10669761 RXRA Affinity Capture-Western physical 11714715 RXRA Reconstituted Complex physical 11714715 RXRA Two-hybrid physical 11714715 RXRA Two-hybrid physical 11714715 NR3C1 Two-hybrid physical 10713165 NCOA1 Affinity Capture-Western physical 10558993 NCOA1 Reconstituted Complex physical 10558993 NCOA1 Reconstituted Complex physical 10558993 CREBBP Reconstituted Complex physical 10558993 NCOA1 Affinity Capture-Western physical 10558993 CREBBP Affinity Capture-Western physical 10558993 CREBBP Reconstituted Complex physical 10558993 CREBBP Affinity Capture-Western physical 10558993 PPARG Reconstituted Complex physical 10558993 FBXW7 Affinity Capture-Western physical 18198341 FBXW7 Affinity Capture-Western physical 18198341 FBXW7 Reconstituted Complex physical 18198341 UBC Affinity Capture-Western physical 18198341 GSK3B Biochemical Activity physical 18198341 EP300 Affinity Capture-MS physical 17050673 IQGAP1 Affinity Capture-MS physical 17050673 LRPPRC Affinity Capture-MS physical 17050673 LRPPRC Reconstituted Complex physical 17050673 LRPPRC Reconstituted Complex physical 17050673 LRPPRC Affinity Capture-Western physical 17050673 SIRT1 Co-localization physical 19553684 MYOD1 Co-localization physical 19553684 HNF4A Reconstituted Complex physical 18552123 NCOA6 Reconstituted Complex physical 18552123 ESRRG Reconstituted Complex physical 15821111 ESRRA Co-crystal Structure physical 15337744 NR1I2 Reconstituted Complex physical 15322103 NR1I2 Reconstituted Complex physical 15322103 HNF4A Reconstituted Complex physical 15322103 HNF4A Reconstituted Complex physical 15322103 NR1I2 Affinity Capture-Western physical 15322103 MYEF2 Affinity Capture-Western physical 15111488 HNF4A Affinity Capture-Western physical 17636037 SF1 Affinity Capture-Western physical 20133449 NR5A2 Affinity Capture-Western physical 20133449 HNF4A Reconstituted Complex physical 20926756 BCL6 Affinity Capture-MS physical 16147992 NR1I2 Two-hybrid physical 15604093 ESR2 Two-hybrid physical 15604093 UBC Affinity Capture-Western physical 22064484 RNF34 Affinity Capture-Western physical 22064484 ESRRA Two-hybrid physical 12181319 ESRRA Reconstituted Complex physical 12181319