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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for COPS5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10987
Official gene symbolCOPS5
Full nameCOP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Aliases,CSN5,JAB1,MGC3149,MOV-34,SGN5,
Gene summaryThe protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q13.1
Gene position67974562 - 67955314  Map Viewer
Gene orientationminus
Gene size19249 bp
Gene sequence
OMIM ID604850