Entrez gene ID | | 11213 |
Official gene symbol | | IRAK3 |
Full name | | interleukin-1 receptor-associated kinase 3 |
Aliases | | ,ASRT5,FLJ13601,IRAKM, |
Gene summary | | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q14.3 |
Gene position | | 66582978 - 66648402 Map Viewer |
Gene orientation | | plus |
Gene size | | 65425 bp |
Gene sequence |
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OMIM ID | | 604459 |
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