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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IRAK3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001960 negative regulation of cytokine-mediated signaling pathway IC GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0006468 protein phosphorylation IDA GO:0007165 signal transduction IEA GO:0009615 response to virus IC GO:0010933 positive regulation of macrophage tolerance induction ISS GO:0010936 negative regulation of macrophage cytokine production ISS GO:0019221 cytokine-mediated signaling pathway ISS GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP GO:0032494 response to peptidoglycan ISS GO:0032496 response to lipopolysaccharide ISS GO:0032695 negative regulation of interleukin-12 production IMP GO:0032695 negative regulation of interleukin-12 production ISS GO:0032715 negative regulation of interleukin-6 production IMP GO:0032715 negative regulation of interleukin-6 production ISS GO:0032720 negative regulation of tumor necrosis factor production IMP GO:0034122 negative regulation of toll-like receptor signaling pathway ISS GO:0042177 negative regulation of protein catabolic process IMP GO:0043242 negative regulation of protein complex disassembly IMP GO:0043244 regulation of protein complex disassembly ISS GO:0043330 response to exogenous dsRNA ISS GO:0043407 negative regulation of MAP kinase activity IMP GO:0045824 negative regulation of innate immune response ISS GO:0046777 protein autophosphorylation IEA GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP GO:0070498 interleukin-1-mediated signaling pathway IMP GO:0070555 response to interleukin-1 IMP cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA molecular_function GO:0000166 nucleotide binding IEA GO:0000287 magnesium ion binding IDA GO:0004674 protein serine/threonine kinase activity IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0042803 protein homodimerization activity IPI GO:0046982 protein heterodimerization activity IPI

Protein-protein interaction details for IRAK3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MYD88 Affinity Capture-Western physical 10383454 TRAF6 Affinity Capture-Western physical 10383454 IRAK1 Affinity Capture-MS physical 21903422 IRAK2 Affinity Capture-MS physical 21903422 IRAK4 Affinity Capture-MS physical 21903422