Entrez gene ID | | 1398 |
Official gene symbol | | CRK |
Full name | | v-crk sarcoma virus CT10 oncogene homolog (avian) |
Aliases | | ,CRKII, |
Gene summary | | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13.3 |
Gene position | | 1359544 - 1325440 Map Viewer |
Gene orientation | | minus |
Gene size | | 34105 bp |
Gene sequence |
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OMIM ID | | 164762 |