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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CRK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1398
Official gene symbolCRK
Full namev-crk sarcoma virus CT10 oncogene homolog (avian)
Aliases,CRKII,
Gene summaryThis gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq]
LocationChromosome: 17   Locus: 17p13.3
Gene position1359544 - 1325440  Map Viewer
Gene orientationminus
Gene size34105 bp
Gene sequence
OMIM ID164762