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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CTLA4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1493 Official gene symbol CTLA4 Full name cytotoxic T-lymphocyte-associated protein 4 Aliases ,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,ICOS,IDDM12, Gene summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq] Location Chromosome: 2   Locus: 2q33 Gene position 204732509 - 204738683  Map Viewer Gene orientation plus Gene size 6175 bp Gene sequence >CTLA4:54941927..54948101:Length=6175 GCCTTCTGTGTGTGCACATGTGTAATACATATCTGGGATCAAAGCTATCTATATAAAGTC CTTGATTCTGTGTGGGTTCAAACACATTTCAAAGCTTCAGGATCCTGAAAGGTTTTGCTC TACTTCCTGAAGACCTGAACACCGCTCCCATAAAGCCATGGCTTGCCTTGGATTTCAGCG GCACAAGGCTCAGCTGAACCTGGCTACCAGGACCTGGCCCTGCACTCTCCTGTTTTTTCT TCTCTTCATCCCTGTCTTCTGCAAAGGTGAGTGAGACTTTTGGAGCATGAAGATGGAGGA GGTGTTTCTCCTACCTGGGTTTCATTTGTTTCAGCAGTCAAAGGCAGTGATTTATAGCAA AGCCAGAAGTTAAAGGTAAAACTCCAATCTGGCTTGGCTGGCTCTGTATTCCAGGGCCAG CAGGGAGCAGTTGGGCGGCAGCAAATAAGGCAAAGAGATAGCTCAGAACAGAGCGCCAGG TATTTAGTAGGGGCTTCATGAATGCATGTGAGTTGGTTTAGTAGAGAGACACAGGCAATT TCAGACCCTTCTATGAGACTGGAAGTGATTTAAGAGGGAAAGGATAGCCATAGTCCTGAA TACATTTGAGCTGGGTTTCAGGATGAGCTCACAAGTTCCTTTAAAAAAAATTGACTTAAG CAAATCCTGGGAAGAGTTTTTTTGCTATACAATTCAAGGTTTTAAGGTCCTCGGATTCAT ATACTTTATAAATGAATTAGCCAGCTTGTTTAAAATGTAGGGAAATTGTGGGAAGAATGC CTTCTTTACTTAATTCAAGGTTTTAAGGTTCTCTTAATCAATTCTACTAGCTAATTAGCC AATTATTTAAAAATAAAAGTTTGAAATTGCCAAAAAAAAAAGACAAGGAAAAGGAAAGAA AGAAAGCCACCAGTCTGTTTGGCATACAATACTTAATTGTTGCCTGACCTACGTGTGGGT TTCAGATGCAGATCCTCAGTTTTCAGCTCTTCAGAGACTGACACCAGGTTTGTTACACGG CTTAAAATGATGAGTATATCCATTGAATCTCAACCTTATCTCTCTCTAGACCTTCTTGGT TAAGAAACCATGTAGTTTGTATGAAGTAGGTACTCAAAAGATATTTGATGATTTAATTTT TACTGGAGAAGAAATATTCATATATGTTTTCTTATTTTTACATGTTTTAAATATGTAAAG ATTAAATAAACACTCTTAGAAGTATTTAAATTTCCTAAAGTAAATTTATCTCAACCAGTA ACAGGACCCTCCCAATACTGGAAAGTTGAGTGTGACCGCATTTAGTGGTGATGAGTGTGA GCTTGCTTGGGGAGAGGGCAGGACATTTAGGATTTCTTAAGCTTAGAGTCAATACAATAA AGATTATTGAGTGCTCACTTGGGTGGGCTATAATCACTGCTCACAGGAGTTCATGAACCA CAAGTAAAAGAGTGAGGAGATATGATTAGCTCACAAATAACTTTAATACAGAGCAGAAAG TAATGAACTACTGCAATGGAGTTATCACAGTGCTAAGGATGCTCAGAGGGCATCTCTGAT AGGCAGAGGTGAGGGTTAGGGAAGGAAGCTGTAGTCTAGCTAGCTAGAGCTGCTGGAATA GACATGACAATGGCTGCTGCCAAACTGTTTTCTCTTCTGAGGACAGATGTCCCGTGCAAG TGGCTTGGTGGAAGGGACTAGTGTCTCTAATATAGGGTGATTTATAAGCAGGAAAGTGTG TCCTAGAAATTCAGACCAGAGTGATAGATTGGAATTGGATCATGGGGGACTCATTGAATG TTATTTATTGTATTTGTTTTTGCGATCAGTGTTAGTAAAGTGTCAAAGGGATTGAGCAGA TGAGTGACATCATGCAACACAAGTTTTGAGTTTCACTTGTCAGACTGACTGGAGAGGGGC CTGGTTAGTTACAGGAAGGTAATTTGGCATGCAGCCACTATTTTTGAGTTGATGCAAGCC TCTCTGTATGGAGAGCTGGTCTCCTTTATCCTGTGGGAAAAGAGAACAAAGGAGCATGGG AGTGTTCAAGGGAAGGAGAAATAAAGGGCAGAGAGGCAGCGGTGGTGTCAGGGGAAGCCC ACAGGAGTTAACAGCAGGGTTGCCTCAACCTAGAGAGGAAGCGACCTGGTGCCCTCGGCT CTGTGGCTTCCTTCATCTAACAACATCTTCCACTCTACAACAATGCCAGGGAAGGCGGAG GCTGGTACAGTGCATCAAGACACAGCTACTCCTGGGTGACAGAGGTTCAGGGCCAGCTCA CTAAGTAGGCAGAAGTTTTTGACATATACTTTGAGAGATAAAGCAAGATTCTGTACCTCA ACCTTCAGAATTTCCCCTACCACTCATTATAGTTCCGGAGCTATATAGCTCCTATCATTC TATCATAACCTTAGAATACCAGAGAACATATCATCTCATCTAATTATCTCTTACTATATG TGAAAAAAATGAAGGACATGGGGGAAGTGTGACTTGCCCCAAATCACATATTTCATGGTA GAGCCAGGTCTTCTGTTTGTCATATCAGTGTTCTTCCTGCCACAACCATCTTGAAGAATC TATTTCTCAGTAAGAAAATATCTTTATGGAGAGTAGCTGGAAAACAGTTGAGAGATGGAG GGGAGGCTGGGGGTGTGGAGAGGGGAAGGGGTAAGTGATAGATTCGTTGAAGGGGGGAGA AAAGGCCGTGGGGATGAAGCTAGAAGGCAGAAGGGCTTGCCTGGGCTTGGCCATGAAGGA GCATGAGTTCACTGAGTTCCCTTTGGCTTTTCCATGCTAGCAATGCACGTGGCCCAGCCT GCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTATGCATCTCCA GGCAAAGCCACTGAGGTCCGGGTGACAGTGCTTCGGCAGGCTGACAGCCAGGTGACTGAA GTCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGC ACGGGCACCTCCAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGAC ACGGGACTCTACATCTGCAAGGTGGAGCTCATGTACCCACCGCCATACTACCTGGGCATA GGCAACGGAACCCAGATTTATGTAATTGGTGAGCAAAGCCATTTCACTGAGTTGACACCT GTTGCATTGCAGTCTTCTATGCACAAAAACAGTTTTGTTCCTTAATTTCAGGAGGTTTAC TTTTAGGACTGTGGACATTCTCTTTAAGAGTTCTGTACCACATGGTAGCCTTGCTTATTG TGGGTGGCAACCTTAATAGCATTCTGACTGTAAAATAAAATGATTTGGGGAAGTTGGGGC TCTCGCTCTGGAGTGCTAACCATCATGACGTTTGATCTGTACTTTTGATATGATATGATG CTCCTGGGGAAGTAGTCCCAAATAGCCAAACCTATTGGTGGGCTACCCATGCAATTTAGG GGTGGACCTCAAGGCCTGGAAGCTCTAATGTCCTTTTTTCACCAATGTTGGGGAGTAGAG CCCTAGAGTTTAAAACTGTCTCAGGGAGGCTCTGCTTTGTTTTCTGTTGCAGATCCAGAA CCGTGCCCAGATTCTGACTTCCTCCTCTGGATCCTTGCAGCAGTTAGTTCGGGGTTGTTT TTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGGTGAGTGTGGTGCTGATG GTGCACCATGTCTGATGGGGATACCTTTAGTGGTATCAACTGGCCAAAAGATGATGTTGA GTTTAGTGTTCTTGAGATGAGATGAGGCAATAAATGAAGAGGAAGGACAGTGGTAAAGAA CGCACTAGAACCGTAGGCATTGGCATTTGAGGTTTCAGAATGACTAATATTTTAGATGAA TTTGTTTGACATTGAATGTTCATGTGCTTCTGAGCAGGGTTTCAATTTGAGTAACCGTTG CAATAACATGGGGCAGCTGTTTTGCTCTTTGTCTTCATGACAACTGTACTTAAGCTAACA GCCCTGAAACATGAGATTAGGCTGGGCAGAATGCTGCTAGAGAGGACCACTTGGATGGTC TTTATTCTCCTTCTCCATGTCCCTCTCCATCACCTGGAAGTCACCTCTGGGTGCCACTCT GGTGCCTTCCTTGTCGAAGCTGTAGCTGCTCACATGACACCTATCCCTGTTATCCAGTTT GCTTGACTGGGACGTTTTGCCTTCCCCTTCAGCCAGGAAGTGAAAGTCCCAGTTTTTATT TATCACAGGTGTTGGTATTGGTGGTAGAAGAGGTAGAATTATGGAATCAGGCCTCCTGTC AGGATTTCTTTTTGACAGTCCCTCTCAGACACCTCTGCCTAAGGCCAGCTTTGCCATTAC AAACTCTCCCTTCTCCCTCTCTCCCTTCTTCTCTTCCTCTTCCTTCTTCTCGCTCTTTCT CTCTCTCTCTTTCTCCCTCTCTGTCTCTTATACACATACACAAAGATATACTCTATTCCA ACATCCTCTACCCAACCTGACAGAGATGTCCTTTGCTGTAGGTTCAGCAGTGGGGATGAG AAATACAGCTCTCAAACAGGATAACTAAAGCTTATTATCTTATCAAGCTTGTTCCCTTGC AGACAAGATTGATCAATTATCATAGGCTTTCTGGGTGTTCTTTCTGAAGCTTTCTCAAAG TCTCTTTCTCCTATCTTCCATTCAAGGCAAATGATTGCCATTTAACATCAAAATCACAGT TATTTATCTAAAATAAATTTTAATAGCTGAATCAAGAAAATCTCCTGAGGTTTATAATTC TGTATGCTGTGAACATTCATTTTTAACCAGCTAGGGACCCAATATGTGTTGAGTTCTATT ATGGTTAGAAGTGGCTTCCGTATTCCTCAGTAGTAATTACTGTTTCTTTTTGTGTTTGAC AGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCCCAACAGAGC CAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCATCAATTGAGAAACCATTATGA AGAAGAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCC AGCTATTTTTATTTGTTTGTGCATTTGGGGGGAATTCATCTCTCTTTAATATAAAGTTGG ATGCGGAACCCAAATTACGTGTACTACAATTTAAAGCAAAGGAGTAGAAAGACAGAGCTG GGATGTTTCTGTCACATCAGCTCCACTTTCAGTGAAAGCATCACTTGGGATTAATATGGG GATGCAGCATTATGATGTGGGTCAAGGAATTAAGTTAGGGAATGGCACAGCCCAAAGAAG GAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACACACCTTATATTTACGTATGAGA CGTTTATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAA TGTATGATTACATCAAGGCTTCAAAAATACTCACATGGCTATGTTTTAGCCAGTGATGCT AAAGGTTGTATTGCATATATACATATATATATATATATATATATATATATATATATATAT ATATATATATATATATATTTTAATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTG TGTATTTGTTAATGGTTTGAATATAAACACTATATGGCAGTGTCTTTCCACCTTGGGTCC CAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACACCAGGTAGAACACAAGGTCATT TGCTAACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTGGAATTGTGC TGAGTTGGTGTTGACATGTGCTTTGGGGCTTTTACACCAGTTCCTTTCAATGGTTTGCAA GGAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGAACACTGTCTTGAAGACAATGG CTTACTCCAGGAGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAAT TCTTACAAACATGTGGTTAATGCCATGGACAGAAGAAGGCAGCAGGTGGCAGAATGGGGT GCATGAAGGTTTCTGAAAATTAACACTGCTTGTGTTTTTAACTCAATATTTTCCATGAAA ATGCAACAACATGTATAATATTTTTAATTAAATAAAAATCTGTGGTGGTCGTTTT OMIM ID 123890