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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CTLA4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006955 immune response IEA GO:0006974 response to DNA damage stimulus IMP GO:0030889 negative regulation of B cell proliferation IMP GO:0031295 T cell costimulation TAS GO:0043065 positive regulation of apoptosis IMP GO:0045590 negative regulation of regulatory T cell differentiation IDA GO:0050853 B cell receptor signaling pathway IMP cellular_component GO:0005794 Golgi apparatus IDA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane TAS GO:0009897 external side of plasma membrane IDA GO:0045334 clathrin-coated endocytic vesicle IDA GO:0048471 perinuclear region of cytoplasm IDA molecular_function

Protein-protein interaction details for CTLA4 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CD80 Reconstituted Complex physical 7545666 AP2M1 Co-crystal Structure physical 11583591 CD86 Co-crystal Structure physical 11279501 CTLA4 Co-crystal Structure physical 11279502 CD80 Co-crystal Structure physical 11279502 FYN Affinity Capture-Western physical 9712716 LCK Affinity Capture-Western physical 9712716 LYN Affinity Capture-Western physical 9712716 PPP2R5A Affinity Capture-Western physical 11994459 PPP2R5A Two-hybrid physical 11994459 AP2M1 Affinity Capture-Western physical 9200449 AP2M1 Reconstituted Complex physical 9200449 AP2M1 Two-hybrid physical 9200449 AP1M1 Co-crystal Structure physical 9812899 JAK2 Affinity Capture-Western physical 10842319