Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CYP3A4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1576
Official gene symbolCYP3A4
Full namecytochrome P450, family 3, subfamily A, polypeptide 4
Aliases,CP33,CP34,CYP3A,CYP3A3,HLP,MGC126680,NF-25,P450C3,P450PCN1,
Gene summaryThis gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q21.1
Gene position99381808 - 99354604  Map Viewer
Gene orientationminus
Gene size27205 bp
Gene sequence
OMIM ID124010