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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DAXX (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1616 Official gene symbol DAXX Full name death-domain associated protein Aliases ,BING2,DAP6,EAP1,MGC126245,MGC126246, Gene summary This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 33290793 - 33286335  Map Viewer Gene orientation minus Gene size 4459 bp Gene sequence >DAXX:complement(4730149..4734611):Length=4463 ACGACAATATGGCGGCGCTTAGTTGCATGAAGGCGGAAACTCTGTGACTTCCGGTCCGTA GTGGGGCCTGCGGTGGGAGTGGGAAGGAAGGCGGAGGGAACCATGCGAGGTTCTGAGAAT TGCGGCGAGGGTCGCCTCGAGAGACGGTTTCTGAGGTGGGGGCCGGACGGTGCGGGGATC AGAGGCGGGGGCGGGGATATAGAGGGAGAGGTATTGGGGAGAGCTGGGCGCTGAGTCTGA GGGGAATGCTGTGGTACCTTCCTGTCCCTGAAAGGGAGTGGAGCGGCCGGGGGCTGAACT GGGGGAGGGGGATTTGGCGGGAAGCGCATCTAGCGGACCGGCCGGACCCACGGTTGGGAT CTAAGAGGAATCGCGAGAGCGTAGCGCGGTGTGGGGGGACTTTTGATCAGTTACGGGTCA CCGAGAGAATGGGGAAAATTAGGGTGGGGTGAAAGGGAGGGGACTTGGGTAAAATATCTT CAACCTAAAGCCCCAGTTTGAGGAGACTCATCGGAGGGTGAAATATGGAGATAATTCAAG GAGGAGAAAAGAGAACGGACTGTTGGGAGGGAACCTCTTTCACCTCAGAGAGTCTAGGAG TTGGGGTGATCATTCAGGATAGGGTGGGTGTGGGGTTGACTTGTTTGAGAGCAGAGGGGG CAAACACATGAGGTGGCGCCCACAGGAGTGTGTTGTCTGTGCAAGGGGGTGTCAGGACGA TTTGGGGTGCAGTGTGGGAGGAAGAATCAACTTGCCAACTCTAAGAAATAGGGGGGAAAT GCAACAGAAAGACCGGAAATCGACGTGAGGGGTGGAGCAGAAGGTGGCAACTTAAGGTGT GGGGGTGGTTTGCCCCCCCCCCCCACACCACTTGAAGGGCCCCAAAAAGCATATAGAACT AATGGTTATTGAAATCAGGTGGTGAAGACAGTGTTGGTCAGGGCTGGATGTTACTGAAAC CCAAGGAGTTCAGAAAATGTGTGAGGTGAAGGGATGGGGCTATGCTGGAGGGGCTCATTC TGAGGCCCCATCCCCTTCCAGCAGGAATTCTGAAATCCCCACCACTTCCTCCCTCCGGGG GATTTGATCCCCTATGGCCACCGCTAACAGCATCATCGTGCTGGATGATGATGACGAAGA TGAAGCAGCTGCTCAGCCAGGGCCCTCCCACCCACTCCCCAATGCGGCCTCACCTGGGGC AGAAGCCCCTAGCTCCTCTGAGCCTCATGGGGCCAGAGGAAGCAGTAGTTCGGGCGGCAA GAAATGCTACAAGCTGGAGAATGAGAAGCTGTTCGAAGAGGTGAGCTTTAGCGGGGAAGA TTGTTGTACCCCAGGGAGGGGGATGGCTGACTGGTTCTCCTGTCCTTTCTTTCCCACTAA CCCCACCTCCCCTTTCTCTCAACCCCCTCCCTTGTCTCTCTTCCCCTTCCTTCTTCCCCT GAACCTTCTAGTTCCTTGAACTTTGTAAGATGCAGACAGCAGACCACCCTGAGGTGGTCC CATTCCTCTATAACCGGCAGCAACGTGCCCACTCTCTGTTTTTGGCCTCGGCGGAGTTCT GCAACATCCTCTCTAGGGTCCTGTCTCGGGCCCGGAGCCGGCCAGCCAAGCTCTATGTCT ACATCAATGAGCTCTGCACTGTTCTCAAGGCCCACTCAGCCAAAAAGAAGCTGAACTTGG CCCCTGCCGCCACCACCTCCAATGAGCCCTCTGGGAATAACCCTCCCACACACCTCTCCT TGGACCCCACAAATGCTGAAAACACTGCCTCTCAGTCTCCAAGGACCCGTGGTTCCCGGC GGCAGATCCAGCGTTTGGAGCAGCTGCTGGCGCTCTATGTGGCAGAGATCCGGCGGCTGC AGGAAAAGGAGTTGGATCTCTCAGAATTGGATGACCCAGACTCCGCATACCTGCAGGAGG CACGGTTGAAGCGTAAGCTGATCCGCCTCTTTGGGCGACTATGTGAGCTGAAAGACTGCT CTTCACTGACCGGCCGTGTCATAGAGCAGCGCATCCCCTACCGTGGCACCCGCTACCCAG AGGTTAACAGGCGCATTGAGCGGCTCATCAACAAGCCAGGGCCTGATACCTTCCCTGACT ATGGGGATGTGCTTCGGGCTGTAGAGAAGGCAGCTGCCCGACACAGCCTTGGCCTCCCCC GACAGCAGCTCCAGCTCATGGCTCAGGATGCCTTCCGAGATGTGGGCATCAGGTTACAGG AGCGACGTCACCTCGATCTCATCTACAACTTTGGCTGCCACCTCACAGATGACTATAGGC CAGGTAGGGGGTTGGTGGGATGCCTCTCAGTGACCCTTATATGTCAGGTATGAGGCGGAT GGGGCATCTCTCTAGTCCTTTCTAGGGTTTTTACTCTTCTAGTCCCTTCAAGGGCTGAGT GCTCTGACTTTATGTCTTCCCACGTAGGCGTTGACCCTGCACTATCAGATCCTGTGTTGG CCCGGCGCCTTCGGGAAAACCGGAGTTTGGCCATGAGTCGGCTGGATGAGGTCATCTCCA AATACGCAATGTTGCAAGACAAAAGTGAGGAGGGCGAGAGAAAAAAGAGAAGAGCTCGGC TCCAAGGCACCTCTTCCCACTCTGCAGACACCCCCGAAGCCTCCTTGGATTCTGGTGAGG TGTGGATGGGGTACAGCCTTCAGAGAGACATTGTCCTTCCCCTGCACTGGCCACCAGGGA GTCCAGGTTGACTGATGGGGTAGCATGAGAAGGAAAGCAAGAACCAAACCCTCTGGGGCA AGGGATTCCTTAGAGAAACTTCTTTGTCTCCCAGGGCCCTAGTGGAATGGCATCCCAGGG GTGCCCTTCTGCCTCCAGAGCTGAGACAGATGACGAAGACGATGAGGAGAGTGATGAGGA AGAGGAGGAGGAGGAGGAAGAAGAAGAGGAGGAGGCCACAGATTCTGAAGAGGAGGAGGA TCTGGAACAGATGCAGGAGGGTCAGGAGGATGATGAAGAGGAGGACGAAGAGGAAGAAGC AGCAGCAGGTATGTCAAGGGAACATTCTCCTCACCTGTCATTTCTGTTTTGTTAGGCATG AGCCACCTGTTTGAAACCTTTCCCTTCCTCCTCCTAGTGTCCTCTCAGCAGTATTTTTTC CCCCTCATTCTCAGGCTACCCTCTCCCCTTTTCTTCTTTTCCAGGTAAAGATGGAGACAA GAGCCCCATGTCCTCACTACAGATCTCCAATGAAAAGAACCTGGAACCTGGCAAACAGAT CAGCAGATCTTCAGGGGAGCAGCAAAACAAAGGACGCATAGTGTCACCATCGTTACTGTC AGAAGAACCCCTGGCCCCCTCCAGCATAGATGCTGAAAGCAATGGAGAACAGCCTGAGGA GCTGACCCTGGAGGAAGAAAGCCCTGTGTCTCAGCTCTTTGAGCTAGAGATTGAAGCTTT GCCCCTGGATACCCCTTCCTCTGTGGAGACGGACATTTCCTCTTCCAGGAAGCAATCAGA GGAGCCCTTCACCACTGTCTTAGAGAATGGAGCAGGCATGGTCTCTTCTACTTCCTTCAA TGGAGGCGTCTCTCCTCACAACTGGGGAGATTCTGGTCCCCCCTGCAAAAAATCTCGGAA GGAGAAGAAGCAAACAGGATCAGGGCCATTAGGAAACAGGTAATAACAAGAGGAGGAGGA AGAGGGAAGCCAAGGAGGGATTGCAGGGGACTTTCGGAGAGCAATACTGGGGAACTGAGT CTGCTGGGAGAGACTGGACTGCCCCCCTCCAGCCTCAGTCTTCCCGTACCCCTCCACATA TTTATGTTTCTGTTTCTAGCTATGTGGAAAGGCAAAGGTCAGTGCATGAGAAGAATGGGA AAAAGATATGTACCCTGCCCAGCCCACCTTCCCCCTTGGCTTCCTTGGCCCCAGTTGCTG ATTCCTCCACGAGGGTGGACTCTCCCAGCCATGGCCTGGTGACCAGCTCCCTCTGCATCC CTTCTCCAGCCCGGCTGTCCCAAACCCCCCATTCACAGCCTCCTCGGCCTGGTACTTGCA AGGTAAGAAGGGGAGGGCGTGTTTCCTCTGACAATTTGTTCTCTTTCATTGGCTGTTTCA GCTGCTCTGTCTGAATATTCCACGTGCCACATCCTGTCTCTTCCTTTTTCCCACCCATTT TATCCTCTAAATCCTCCTGTTTCTTTTCTCCTGTACTCCAGATCTCTTTGACTCTTTGTC TCTCACTTCCCTGCAGACAAGTGTGGCCACACAATGCGATCCAGAAGAGATCATCGTGCT CTCAGACTCTGATTAGCTGCCTCCCCTTCTCCCTGCCTCCAGAATGTTCTGGGATAACAT TTGGAGGAAGGTGGGAAGCAGATGACTGAGGAAGGGATGGACTAAGCTAATCCCCTTTTG GTGGTGTTTCTTTAAAAAAAAAAAAAAAAGCTTAAGTTTTACACAGAAACATTAATAAAC AATAAAGTTCTTTTCTTACTGTA OMIM ID 603186