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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP6 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1848 Official gene symbol DUSP6 Full name dual specificity phosphatase 6 Aliases ,MKP3,PYST1, Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 12   Locus: 12q22-q23 Gene position 89746296 - 89741837  Map Viewer Gene orientation minus Gene size 4460 bp Gene sequence >DUSP6:complement(51885143..51889602):Length=4460 GAGACGCTCGCTGTTTGTATCCATTGAGGAGCTGCCTCGCGCAGGGGGTGTGCGAGGCTG AGTCCAAGAGATAGCAAATCGAGTCTTAAATAATCCGGGGAGAAAGACGCCCGGGTAGAT TTGAGGTGCAGCCTTGGAGGGAGGGATTAGAAGCCGCTAGACTTTTTTTCCTCCCCTCTC AGTAGCACGGAGTCCGAATTAATTGGATTTCATTCACTGGGGAGGAACAAAAACTATCTG GGCAGCTTCATTGAGAGAGATTCATTGACACTAAGAGCCAGCGGCTGCAGCTGGGTGCAG AGAGAACCTCCGGCTTTACTTCTGTCTCGTCTGCCCCAACCGCTAGCCTCGGCTTGGGTA AGGCGAGGCGGAATTAAACCCCGCTCCGAGAGCGGCAGCTTCGCGCGCGGTGCGCTCGGC CTATGCCTGCCCCGAGGGGCGTCTGGTAGGCACCCCGCCCTCTCCCGCAGCTCGACCCCC ATGATAGATACGCTCAGACCCGTGCCCTTCGCGTCGGAAATGGCGATCAGCAAGACGGTG GCGTGGCTCAACGAGCAGCTGGAGCTGGGCAACGAGCGGCTGCTGCTGATGGACTGCCGG CCGCAGGAGCTATACGAGTCGTCGCACATCGAGTCGGCCATCAACGTGGCCATCCCGGGC ATCATGCTGCGGCGCCTGCAGAAGGGTAACCTGCCGGTGCGCGCGCTCTTCACGCGCGGC GAGGACCGGGACCGCTTCACCCGGCGCTGTGGCACCGACACAGTGGTGCTCTACGACGAG AGCAGCAGCGACTGGAACGAGAATACGGGCGGCGAGTCGGTGCTCGGGCTGCTGCTCAAG AAGCTCAAGGACGAGGGCTGCCGGGCGTTCTACCTGGAAGGTACGCGCCCAGGGAACTCC GCGCGCGGGGCAGGGCTAGGGGCGCAGGGCTGCGGGCGGGGCGCGTGGATTGAAAATACC TCTGCTCCGCTCAGCTGGAGCTTCGGAGCCGCGCTGCCCGCCTAGGGACCGGCAGCCGGC GAGGTAGGGGCCGCGAACCGCGCGTTCCGCACCAGAGAACCGGGCCGGCTCAGAATCCAC TCGCTTCCGGCTGCGGGTACCGGCGGTTTCTTTCTAACGGGTTCTGCGCCTTCTTAGCCA GAACATCCTCCACCATCACCCTGTTTTCTATCGTTCGATTTTGAATTAAGATTTGCAGGA CGGGAGAGATTGTTGGGGATGCAAATTGGCACATCTTAGCTCTCAAAATATTCCAAAAAG TTGCCATTTTGTCTATTTCCGGATTCAAGCGAATAAGGGTTCCCTGGCGAGGCGGGCCCG TTCGTTCCATTCCCGATGGTGCACATTTAAAGTGTGTTTCTCTTATAGATGGTTCTGTAT GTAGGGGGTTCGTAGGATGCTTGTGGTGTTTCTTGCGCCGGGCTGCGGTTCTTACAAGCT GTGAAAACTACTACGGCTTCTCAGGTTAGATGATTGCTTTTCTCGTTCTGGCAGGTGGCT TCAGTAAGTTCCAAGCCGAGTTCTCCCTGCATTGCGAGACCAATCTAGACGGCTCGTGTA GCAGCAGCTCGCCGCCGTTGCCAGTGCTGGGGCTCGGGGGCCTGCGGATCAGCTCTGACT CTTCCTCGGACATCGAGTCTGACCTTGACCGAGACCCCAATAGTGCAACAGACTCGGATG GTAGTCCGCTGTCCAACAGCCAGCCTTCCTTCCCAGTGGAGATCTTGCCCTTCCTCTACT TGGGCTGTGCCAAAGACTCCACCAACTTGGACGTGTTGGAGGAATTCGGCATCAAGTACA TCTTGAACGTCACCCCCAATTTGCCGAATCTCTTTGAGAACGCAGGAGAGTTTAAATACA AGCAAATCCCCATCTCGGATCACTGGAGCCAAAACCTGTCCCAGTTTTTCCCTGAGGCCA TTTCTTTCATAGGTGAGACTAATTAATAGTCGTCGCTCTGACATTTAAATGCAAAATTCC TAGCCATTCATAGAGTTTAAGCTGTTAATCGTTCTTGCTGCTTGCTAATTTGTCTGACTG CAGGTCTCTAATGTTCCTAGAGCGTCCTTAATTCTGGTTTATCTTCTTGCTAAAGGAAGA AAACCTGCCTTTTGACATGGCTGCAGATCACAGGTGTATTTGAAACGCTGTTTCTTGAAT CTTTGAATTCAGTCATTGACAGTCGTTCATAATCGGACAACAGATTTTTCCCCCCAGTCT TTGGACTCAGGGGAAGGGTCAGATAGAAGTACTCACTATAGACAGGAATTCCAGCATTGC TTTATAATTTAAAAACATCTAGGAGTTATTTTAGGACATCAAGTTAGTTGTTGGAAAGCA GTATGAATGCTGAATGTTATCCAGTTGAATGATGCGGTGATACTGGTAACAGTGAGACAG TGGGTAACCTGAGCCCAGCAGGAAGAACTGTGGGCTGGAAGCCTGGGAGAAGTGAATCTC CAGGCATTGTAATGCATTTCCTATTACAAAGGAACTCATTTTCAGGCCGTGTCGACATCC TGTTCCTCCTAATGGGCCGTCCCCTGTGACTTCCCTCTCTCTTTTAAAATGCCTGAATAC CTCCATTGTTAGCTGCACAACATTTGGAGCATAATTTAATAGACCCTTGCAGTCTGGTTG TCTGTGTAAAAGGCATTCACGAACATATTGCAGGGTTTCTGGTATTCACATGCCGAGGCA AAGAATGCACCCATTAAGGAGTTTTTTGTTGGCAGAAACTTAATACAAAAGCTCTCTTTT CAGAAAATATCTGAAATATGTAATTGTGTCCAGTGTACATGTTTCATTTCAGTGATACAT TTTCTGCTGCTTGTAGGGCTCAACTGCCACACACAACTATTATTATTATTATGTTTTCAA GTTCAGTTTTTAGACTGATCATTCACAAAGGGTGGTTTTCAGTCTGCTGAGATCTTGCTT TTCTTTTTGTGTTCACAGATGAAGCCCGGGGCAAGAACTGTGGTGTCTTGGTACATTGCT TGGCTGGCATTAGCCGCTCAGTCACTGTGACTGTGGCTTACCTTATGCAGAAGCTCAATC TGTCGATGAACGACGCCTATGACATTGTCAAAATGAAAAAATCCAACATATCCCCTAACT TCAACTTCATGGGTCAGCTGCTGGACTTCGAGAGGACGCTGGGACTCAGCAGCCCATGTG ACAACAGGGTTCCAGCACAGCAGCTGTATTTTACCACCCCTTCCAACCAGAATGTATACC AGGTGGACTCTCTGCAATCTACGTGAAAGACCCCACACCCCTCCTTGCTGGAATGTGTCT GGCCCTTCAGCAGTTTCTCTTGGCAGCATCAGCTGGGCTGCTTTCTTTGTGTGTGGCCCC AGGTGTCAAAATGACACCAGCTGTCTGTACTAGACAAGGTTACCAAGTGCGGAATTGGTT AATACTAACAGAGAGATTTGCTCCATTCTCTTTGGAATAACAGGACATGCTGTATAGATA CAGGCAGTAGGTTTGCTCTGTACCCATGTGTACAGCCTACCCATGCAGGGACTGGGATTC GAGGACTTCCAGGCGCATAGGGTAGAACCAAATGATAGGGTAGGAGCATGTGTTCTTTAG GGCCTTGTAAGGCTGTTTCCTTTTGCATCTGGAACTGACTATATAATTGTCTTCAATGAA GACTAATTCAATTTTGCATATAGAGGAGCCAAAGAGAGATTTCAGCTCTGTATTTGTGGT ATCAGTTTGGAAAAAAAAATCTGATACTCCATTTGATTATTGTAAATATTTGATCTTGAA TCACTTGACAGTGTTTGTTTGAATTGTGTTTGTTTTTTCCTTTGATGGGCTTAAAAGAAA TTATCCAAAGGGAGAAAGAGCAGTATGCCACTTCTTAAAACAGAACAAAACAAAAAAAGA AAATTGTGCTCTTTTCTAATCCAAAGGGTATATTTGCAGCATGCTTGACTTTACCAATTC TGATGACATCTTTACGGACACTATTATCACTAAGACCTTGTTATGGCGAAGTCTTTAGTC TTTTTCATGTATTTTCCTCATGATTTTTTCTCTTTATGTAGTTTGACTATGCCTTACCTT TGTAAATATTTTTGCTTGTGTTGTCGCAAAGGGGATAATCTGGGAAAGACACCAAATCAT GGGCTCACTTTAAAAAAAGAAAGAATAAAAAAACCTTCAGCTGTGCTAAACAGTATATTA CCTCTGTATAAAATTCTTCAGGGAGTGTCACCTCAAATGCAATACTTTGGGTTGGTTTCT TTCCTTTAAAAAAATTTGTATAAAACTGGAAGTGTGTGTGTGTGAGCATGGGTACCCATT TGATAAGAGAAATGCATTTGATTGTGAAGAAGGGAGAGTTAAATTCTCCATTATGTTCGT GGTGTAAAGTTTAGAGCTGGAATTTATTATAAGAATGTAAAACCTTAAATTATTAATAAA TAACTATTTTGGCTATTGAA OMIM ID 602748