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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF4E (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1977
Official gene symbolEIF4E
Full nameeukaryotic translation initiation factor 4E
Aliases,CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573,
Gene summaryAll eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM]
LocationChromosome: 4   Locus: 4q21-q25
Gene position99851786 - 99799607  Map Viewer
Gene orientationminus
Gene size52180 bp
Gene sequence
OMIM ID133440