Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ERBB3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2065
Official gene symbolERBB3
Full namev-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Aliases,ErbB-3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB-3,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3,
Gene summaryThis gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q13
Gene position56473892 - 56497128  Map Viewer
Gene orientationplus
Gene size23237 bp
Gene sequence
OMIM ID190151