Entrez gene ID | | 2150 |
Official gene symbol | | F2RL1 |
Full name | | coagulation factor II (thrombin) receptor-like 1 |
Aliases | | ,GPR11,PAR2, |
Gene summary | | Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q13 |
Gene position | | 76114833 - 76131140 Map Viewer |
Gene orientation | | plus |
Gene size | | 16308 bp |
Gene sequence |
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OMIM ID | | 600933 |