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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FEN1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2237 Official gene symbol FEN1 Full name flap structure-specific endonuclease 1 Aliases ,FEN-1,MF1,RAD2, Gene summary The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq] Location Chromosome: 11   Locus: 11q12 Gene position 61560150 - 61564710  Map Viewer Gene orientation plus Gene size 4561 bp Gene sequence >FEN1:6865945..6870505:Length=4561 AGTCCTGCGATTTCGGGTGTAGAGGGAGCAGGGGCCTGCGGGGACCTGGTGTGGGTGGAG TGGGGACAAGCGGTGGAGAAGGGTACGCCAGGGTCGCTGAGAGACTCTGTTCTCCCTGGA GGGACTGGTTGCCATGAGAGCAGCCGTCTGAGGGGACGCAGCCTGCACTACGCGCCCCAA GAGGCTGTGCGTGGCGAGCAGGTCACGTGACGGGAGCGCGGGCTTTGGAAGGCGGCTGAA CGTCAGGCCACCCGCCGCTAAGCTGAGAAGGGAGAGCGAGCTTAGGACCGCCTGCCCGGG GCAACCCCGAACCAAGCTTTAGCCGCCGAGGCCGCGTGTCCCAAAGGCCAGGTGAGACCC CATGGGAAGCGCCTCCGGGAGCGACGGGGTCCGCTTGGCGCTGGGGGCCGTGGGGAGCCG GGGTCTGGAGTGCGCGGGATTCGCAGTCAAGAGGTCCCGCCACTTTTCCCCCTGTGAGCC TTGGGCCAGTCGCGTAAGCTCCGAGCCTCTCTTTCCTCCATTGTAGAAAAGCGGTAATAA GTTCCACCTTATGGGGTCGTGTTGTATTTTTCCTAAGACCTTGGACGAGAAACATTTCTG ACACTTGAGTTGTTTAGGCCCCTTTCCTGCCTACCTGTCTGTGGGACGCCGTGAGGGGAT CAAGGGCTACATGGTCTGGTCCTCAGTCCACACTCCAGCAGCGCGGCCGGCTTGAGGCAA GAGCCGAAGGGTTGAACAGGCCTGGAGAGGGGACATTAGAGGTTTCTGTCTGTTGTCTCA GTTAACCCTGGCAGCAGCCCTGAGAGACAGGCATGGTAATCGTTCTTCTTCTGTAGACGA GAAAATAAACCTCAGTGGCTTGGTAATGTCACACGGATGGTAAATGCCGCGCCTAGATTC AAGGCCAGAGCTTTTGCCGCTGCAGTTCACAGGGGAATTATTCATATTAATCAAATGAAT AATTCATTGTCAATTAATTATTAATTGATTAATAATCCAGGGATGGACCTGGAAGGACGC GTGAGAGGATGGCGAGAGGAGGGCACAGCTAAGGAAAAGTGGGAAAAGGCGGGCCTTATT CCAGCTTTCTGTTGAGATCCCAGAATGTAGGGTTAGGTTGGGAACCAGAACATGAAAGAT CGTGATGCCATGCTGAAGTGTTTGGACTGAATTAGAAGGAAGAATTGAACAGTCATTGAT GCTCTAGAAAGAACCCTGTGAAGAAAGAGTGGGAACAATGAAAAGGCCTGATGGAGTCTT TCGTTTCTTCTTTCTCTTTTCTTTTGTCTTCTTTTCTTTTCTTGACAGGGTCTTGCTCTG TTGCCCAGGCTGGAGTGTGGTGGCACAATCATAGCTCACTGTAGCCTGGAACTCCTGGGC TCATGTGATCCTCCCACCACGGCCTCCCAAAGTGCTGGGATTACTGCCCAGAGCCTCTGT GCCTGGCCCCAGTAGAATATTTCTTGGAGTATTGGACACATACCAACAGTGGGCACAAGA TGAGTTTTTTATTTTTTTGAGACGGAGTCTCACTCTCTTGCTAGGCTGGAGTGCAGCGGC ACAATCTCGGCTCACTGCATTCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCC TCCCGAGTAGCTGGGATTACAGGTGCACACCACCACACCCAGCTAATTTTTTTTTTTTTT GTATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCCAGGATGGCAAGATGATTTTAAAT TGCACCCCCTAAAAATCCTTTTTAATAGTTATACATTTAATACATATTAAAATATAACTA ATAGAACACAAATATTATTGCTTATGAGTTTTCCAGTTTAGTTTTTTAAAAAAAATTCTA AGTGAATGAAAGTACGGGTTTTAGTTGGAAGTAGCAAAAATCGTGAGGGTGATTTGGGAA ACACTGCTATCTGGGAAACACTGAACTCTGAAGTGCAATACTCTTTTGAGCCCAGTGACT ACAGCATGCCAGACCCCTAAATCAGGACCTGGGGAGGAGCCATGGAGTTAACATTTCAGA CTGAGTGGTGGCGAGAAAACGCAAAGGGAAAGACTTGAAACTCTAGCAACATTATAATAA AAGTAGAAACTCTTATGTGCTGAGGCGATGATGAAGAGAGTTTAGAGAAGCTTGTGAGAA AGCCACATCACCTCCATTCAGATATGTTTGCAATCCTTTTTCAAGGCTGCCTTATTAGTC AGGGTTCTCCAGAGACTCAAAACAAATCAGATCTGTTTGTTTAGCTGGTGTATTTGCCTG TCTTTCAGGTCTGCCATTATGGTCCCTGGACTCCTCAAGCCAGGCCAAGCATCCTGGCCT TCTGTGGTCCTTGATGGAGACCTATGTTGCAGGTTTTTTTTGTGTAATAAATAATGCTGC TACCTTAGAATATCAACAGTATCTTATTTCTCTAAGCACGTGGTTCAATTTCTGGTACTC GTTGAGCCTTACTATTGAGTAAATTCTCCTGCTAGACTGAGTTTTTTGAGAATGGGGACC TTGTTCATCTTTTTATCTTTAGCAGTGCTGACATGGTGTCCTTTTTGTTGTGTGGAATTT AGTTGAAGGCATGAAGTTGGTGAGATAACACCAGTTATAACCTTTCTCCTTTCCTCCGTC TCTGACTTGCCTTTCTTTTTTAGTCATCCCTCCTCTGTGTTGCCATGGGAATTCAAGGCC TGGCCAAACTAATTGCTGATGTGGCCCCCAGTGCCATCCGGGAGAATGACATCAAGAGCT ACTTTGGCCGTAAGGTGGCCATTGATGCCTCTATGAGCATTTATCAGTTCCTGATTGCTG TTCGCCAGGGTGGGGATGTGCTGCAGAATGAGGAGGGTGAGACCACCAGCCACCTGATGG GCATGTTCTACCGCACCATTCGCATGATGGAGAACGGCATCAAGCCCGTGTATGTCTTTG ATGGCAAGCCGCCACAGCTCAAGTCAGGCGAGCTGGCCAAACGCAGTGAGCGGCGGGCTG AGGCAGAGAAGCAGCTGCAGCAGGCTCAGGCTGCTGGGGCCGAGCAGGAGGTGGAAAAAT TCACTAAGCGGCTGGTGAAGGTCACTAAGCAGCACAATGATGAGTGCAAACATCTGCTGA GCCTCATGGGCATCCCTTATCTTGATGCACCCAGTGAGGCAGAGGCCAGCTGTGCTGCCC TGGTGAAGGCTGGCAAAGTCTATGCTGCGGCTACCGAGGACATGGACTGCCTCACCTTCG GCAGCCCTGTGCTAATGCGACACCTGACTGCCAGTGAAGCCAAAAAGCTGCCAATCCAGG AATTCCACCTGAGCCGGATTCTGCAGGAGCTGGGCCTGAACCAGGAACAGTTTGTGGATC TGTGCATCCTGCTAGGCAGTGACTACTGTGAGAGTATCCGGGGTATTGGGCCCAAGCGGG CTGTGGACCTCATCCAGAAGCACAAGAGCATCGAGGAGATCGTGCGGCGACTTGACCCCA ACAAGTACCCTGTGCCAGAAAATTGGCTCCACAAGGAGGCTCACCAGCTCTTCTTGGAAC CTGAGGTGCTGGACCCAGAGTCTGTGGAGCTGAAGTGGAGCGAGCCAAATGAAGAAGAGC TGATCAAGTTCATGTGTGGTGAAAAGCAGTTCTCTGAGGAGCGAATCCGCAGTGGGGTCA AGAGGCTGAGTAAGAGCCGCCAAGGCAGCACCCAGGGCCGCCTGGATGATTTCTTCAAGG TGACCGGCTCACTCTCTTCAGCTAAGCGCAAGGAGCCAGAACCCAAGGGATCCACTAAGA AGAAGGCAAAGACTGGGGCAGCAGGGAAGTTTAAAAGGGGAAAATAAATGTGTTTCCCCA TTATACCTCCTTCACCCCAGAATATTTGCCGTCTTGTACCCTTAAGAGCTACAGCTAGAG AAACCTTCACGGGGTGGAGAGAGGATTCTAAGGCTTTTCTAGCGTGACCCTTTTCAGTAG TGCTAGTCCCTTTTTTACTTGATCTTAATGGCAAGAAGGCCACAGAGGTACTTTTCCTTT TTTAGCTCAGGAAAATATGTCAGGCTCAAACCACTTCTCAGGCAGTTTAATGGACACTAA GTCCATTGTTACATGAAAGTGATAGATAGCAACAAGTTTTGGAGAAGAGAGAGGGAGATA AAAGGGGGAGACAAAAGATGTACAGAAATGATTTCCTGGCTGGCCAACTGGTGGCCAGTG GGAGGTGATGGTGGACCTAGACTGTGCTTTTCTGTCTTGTTCAGCCTTGACCCACCTTGA GAGAGAGCCACCAGGAAGGCGCATCTTAGCAGATGGGAGGAACTGCTGAGAGAAGATGGG CAGAAAGCTGGAGCCCCTGGAGTTGGCTGTGTCTGTGTTTGTGACTGATTACTGGCTGTG TCTTGGGTGGGCAGAAACTCGAACTTGCTATGTAATTTGTGTCTAGTTATTCAGAGGAGT AAGATGGTGATGTTCACCTGGCAATCAGCTGAGTTGAGACTTTGGAATAAGACACTGGTT TTCATGCGCTGTTTTTGTTTTAAAGTTATGAAGAAAAAAGTCAATAAAATTCTAAAAGTA A OMIM ID 600393