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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FEN1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000084 S phase of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0000722 telomere maintenance via recombination TAS GO:0000723 telomere maintenance TAS GO:0006260 DNA replication IEA GO:0006260 DNA replication NAS GO:0006271 DNA strand elongation involved in DNA replication TAS GO:0006281 DNA repair IEA GO:0006281 DNA repair NAS GO:0006281 DNA repair TAS GO:0006284 base-excision repair TAS GO:0006302 double-strand break repair TAS GO:0009650 UV protection TAS GO:0032201 telomere maintenance via semi-conservative replication TAS GO:0043137 DNA replication, removal of RNA primer IDA GO:0048015 phosphatidylinositol-mediated signaling NAS cellular_component GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IEA GO:0005739 mitochondrion IDA molecular_function GO:0000287 magnesium ion binding IEA GO:0003677 DNA binding IEA GO:0003677 DNA binding IMP GO:0003684 damaged DNA binding TAS GO:0003690 double-stranded DNA binding TAS GO:0004519 endonuclease activity IEA GO:0004523 ribonuclease H activity IDA GO:0004527 exonuclease activity IEA GO:0004527 exonuclease activity TAS GO:0005515 protein binding IPI GO:0008309 double-stranded DNA specific exodeoxyribonuclease activity TAS GO:0008409 5'-3' exonuclease activity IDA GO:0017108 5'-flap endonuclease activity IDA GO:0017108 5'-flap endonuclease activity IMP GO:0030145 manganese ion binding IEA GO:0048256 flap endonuclease activity IEA

Protein-protein interaction details for FEN1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID HNRNPA1 Two-hybrid physical 14690413 BLM Affinity Capture-Western physical 14688284 BLM Reconstituted Complex physical 14688284 WRN Reconstituted Complex physical 14688284 HNRNPA1 Affinity Capture-Western physical 14690413 HNRNPA1 Reconstituted Complex physical 14690413 HNRNPA1 Two-hybrid physical 14690413 CDK2 Biochemical Activity physical 12853968 CCNA2 Biochemical Activity physical 12853968 CCNA2 Reconstituted Complex physical 12853968 CDK1 Reconstituted Complex physical 12853968 CDK2 Reconstituted Complex physical 12853968 PCNA Reconstituted Complex physical 12853968 CCNA2 Affinity Capture-Western physical 12853968 EP300 Affinity Capture-Western physical 11430825 EP300 Affinity Capture-Western physical 11430825 EP300 Reconstituted Complex physical 11430825 EP300 Biochemical Activity physical 11430825 PCNA Reconstituted Complex physical 11430825 ARHGDIA Two-hybrid physical 16169070 EEF1G Two-hybrid physical 16169070 PCNA Reconstituted Complex physical 9545252 PCNA Reconstituted Complex physical 9305916 PCNA Two-hybrid physical 8876181 PCNA Reconstituted Complex physical 8876181 PCNA Reconstituted Complex physical 8876181 PCNA Co-purification physical 8876181 PCNA Affinity Capture-Western physical 8876181 PCNA Reconstituted Complex physical 11601988 APEX1 Reconstituted Complex physical 11601988 APEX1 Affinity Capture-Western physical 11601988 PCNA Affinity Capture-Western physical 11601988 WRN Affinity Capture-Western physical 11598021 WRN Reconstituted Complex physical 11598021 PCNA Two-hybrid physical 11313979 HUS1 Affinity Capture-Western physical 16216273 RAD9A Affinity Capture-Western physical 16216273 RAD1 Affinity Capture-Western physical 16216273 PCNA Affinity Capture-Western physical 16216273 PCNA Affinity Capture-Western physical 17115032 NCAPG Affinity Capture-Western physical 16543152 WRN Reconstituted Complex physical 16326861 BLM Reconstituted Complex physical 16326861 WRN Affinity Capture-Luminescence physical 16326861 EP300 Biochemical Activity physical 16326861 DDX11 Affinity Capture-Western physical 18499658 DDX11 Affinity Capture-Western physical 18499658 ENDOG Affinity Capture-Western physical 16133872 GSK3B Two-hybrid physical 21900206 PCNA Far Western physical 9178907 PCNA Affinity Capture-Western physical 9178907 UBC Affinity Capture-MS physical 18781797 PCNA Co-crystal Structure physical 15576034 PCNA Protein-peptide physical 15576034 UBC Affinity Capture-MS physical 21987572