Entrez gene ID | | 2244 |
Official gene symbol | | FGB |
Full name | | fibrinogen beta chain |
Aliases | | ,MGC104327,MGC120405, |
Gene summary | | The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q28 |
Gene position | | 155484132 - 155493915 Map Viewer |
Gene orientation | | plus |
Gene size | | 9784 bp |
Gene sequence |
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OMIM ID | | 134830 |
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