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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FGB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2244
Official gene symbolFGB
Full namefibrinogen beta chain
Aliases,MGC104327,MGC120405,
Gene summaryThe protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q28
Gene position155484132 - 155493915  Map Viewer
Gene orientationplus
Gene size9784 bp
Gene sequence
OMIM ID134830