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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SPEN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23013
Official gene symbolSPEN
Full namespen homolog, transcriptional regulator (Drosophila)
Aliases,KIAA0929,MINT,RBM15C,RP1-134O19.1,SHARP,
Gene summaryThis gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.33-p36.11
Gene position16174359 - 16266950  Map Viewer
Gene orientationplus
Gene size92592 bp
Gene sequence
OMIM ID613484