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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SPEN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0007219 Notch signaling pathway IEA GO:0044419 interspecies interaction between organisms IEA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IEA cellular_component GO:0005634 nucleus IDA GO:0005730 nucleolus IDA molecular_function GO:0000166 nucleotide binding IEA GO:0003676 nucleic acid binding IEA GO:0003677 DNA binding IEA GO:0003697 single-stranded DNA binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0003714 transcription corepressor activity IEA GO:0003723 RNA binding IEA GO:0005515 protein binding IPI

Protein-protein interaction details for SPEN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NCOR2 Two-hybrid physical 11331609 PPARD Affinity Capture-Western physical 11867749 NCOR2 Reconstituted Complex physical 11331609 NCOR2 Affinity Capture-Western physical 11331609 HDAC1 Affinity Capture-Western physical 11331609 NCOR2 Reconstituted Complex physical 11331609 HDAC1 Reconstituted Complex physical 11331609 SRA1 Reconstituted Complex physical 11331609 SRA1 Affinity Capture-Western physical 11331609 RBPJ Reconstituted Complex physical 12374742 NCOR1 Reconstituted Complex physical 12897056 NCOR2 Two-hybrid physical 15604093 CTBP1 Affinity Capture-Western physical 16287852 CTBP1 Reconstituted Complex physical 16287852 RBBP8 Reconstituted Complex physical 16287852 RBBP8 Affinity Capture-Western physical 16287852 SUMO1 Reconstituted Complex physical 19596686