Entrez gene ID | | 23118 |
Official gene symbol | | TAB2 |
Full name | | TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
Aliases | | ,FLJ21885,KIAA0733,MAP3K7IP2, |
Gene summary | | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q25.1-q25.3 |
Gene position | | 149639436 - 149732747 Map Viewer |
Gene orientation | | plus |
Gene size | | 93312 bp |
Gene sequence |
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OMIM ID | | 605101 |
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