Entrez gene ID | | 23133 |
Official gene symbol | | PHF8 |
Full name | | PHD finger protein 8 |
Aliases | | ,DKFZp686E0868,JHDM1F,KIAA1111,MRXSSD,ZNF422, |
Gene summary | | The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xp11.22 |
Gene position | | 54071569 - 53963113 Map Viewer |
Gene orientation | | minus |
Gene size | | 108457 bp |
Gene sequence |
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OMIM ID | | 300560 |
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