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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FLNA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2316
Official gene symbolFLNA
Full namefilamin A, alpha
Aliases,ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2,
Gene summaryThe protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
LocationChromosome: X   Locus: Xq28
Gene position153603006 - 153576900  Map Viewer
Gene orientationminus
Gene size26107 bp
Gene sequence
OMIM ID300017