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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FLT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2321
Official gene symbolFLT1
Full namefms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Aliases,FLT,VEGFR1,
Gene summaryThis gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
LocationChromosome: 13   Locus: 13q12
Gene position29069265 - 28874483  Map Viewer
Gene orientationminus
Gene size194783 bp
Gene sequence
OMIM ID165070