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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SIRT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23411
Official gene symbolSIRT1
Full namesirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Aliases,SIR2L1,
Gene summaryThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q21.3
Gene position69644427 - 69678147  Map Viewer
Gene orientationplus
Gene size33721 bp
Gene sequence
OMIM ID604479