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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIRT1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000183 chromatin silencing at rDNA IDA GO:0001542 ovulation from ovarian follicle IEA GO:0006260 DNA replication TAS GO:0006281 DNA repair TAS GO:0006342 chromatin silencing IEA GO:0006342 chromatin silencing TAS GO:0006343 establishment of chromatin silencing IDA GO:0006344 maintenance of chromatin silencing IMP GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006364 rRNA processing IEA GO:0006471 protein ADP-ribosylation TAS GO:0006476 protein deacetylation IDA GO:0006476 protein deacetylation IEA GO:0006476 protein deacetylation IMP GO:0006642 triglyceride mobilization ISS GO:0006974 response to DNA damage stimulus IDA GO:0007275 multicellular organismal development IEA GO:0007283 spermatogenesis IEA GO:0007517 muscle organ development IEA GO:0007569 cell aging TAS GO:0009267 cellular response to starvation ISS GO:0016575 histone deacetylation IDA GO:0016575 histone deacetylation IEA GO:0018394 peptidyl-lysine acetylation IMP GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IMP GO:0031937 positive regulation of chromatin silencing IMP GO:0032071 regulation of endodeoxyribonuclease activity IMP GO:0033158 regulation of protein import into nucleus, translocation IMP GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor ISS GO:0034983 peptidyl-lysine deacetylation IDA GO:0042127 regulation of cell proliferation IMP GO:0042981 regulation of apoptosis ISS GO:0043066 negative regulation of apoptosis IMP GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA GO:0044419 interspecies interaction between organisms IEA GO:0045599 negative regulation of fat cell differentiation ISS GO:0045739 positive regulation of DNA repair IMP GO:0045768 positive regulation of anti-apoptosis IMP GO:0045768 positive regulation of anti-apoptosis TAS GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0050872 white fat cell differentiation ISS GO:0051097 negative regulation of helicase activity IDA GO:0060766 negative regulation of androgen receptor signaling pathway IMP GO:0070301 cellular response to hydrogen peroxide IDA GO:0070932 histone H3 deacetylation IDA GO:0070932 histone H3 deacetylation IMP GO:0080134 regulation of response to stress IDA GO:2000655 negative regulation of cellular response to testosterone stimulus IMP cellular_component GO:0000790 nuclear chromatin IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005635 nuclear envelope IDA GO:0005637 nuclear inner membrane IDA GO:0005654 nucleoplasm IDA GO:0005677 chromatin silencing complex IDA GO:0005719 nuclear euchromatin IDA GO:0005720 nuclear heterochromatin IDA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0016605 PML body IDA GO:0033553 rDNA heterochromatin IDA molecular_function GO:0002039 p53 binding IPI GO:0003714 transcription corepressor activity IDA GO:0003714 transcription corepressor activity ISS GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0004407 histone deacetylase activity IDA GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0008270 zinc ion binding IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA GO:0017136 NAD-dependent histone deacetylase activity IDA GO:0017136 NAD-dependent histone deacetylase activity IEA GO:0019213 deacetylase activity IDA GO:0033558 protein deacetylase activity IDA GO:0034979 NAD-dependent protein deacetylase activity IDA GO:0034979 NAD-dependent protein deacetylase activity IMP GO:0042393 histone binding IPI GO:0042802 identical protein binding IPI GO:0043398 HLH domain binding IPI GO:0043425 bHLH transcription factor binding IPI GO:0046872 metal ion binding IEA GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) ISS GO:0051019 mitogen-activated protein kinase binding IPI GO:0070403 NAD+ binding IEA

Protein-protein interaction details for SIRT1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID HES1 Affinity Capture-Western physical 12535671 HES1 Affinity Capture-Western physical 12535671 HEY2 Affinity Capture-Western physical 12535671 HES1 Reconstituted Complex physical 12535671 HEY2 Reconstituted Complex physical 12535671 HES1 Reconstituted Complex physical 12535671 NR1H3 Affinity Capture-Western physical 17936707 NR1H2 Affinity Capture-Western physical 17936707 USP22 Affinity Capture-MS physical 19615732 KAT5 Affinity Capture-Western physical 20100829 KAT5 Biochemical Activity physical 20100829 MAPK8 Affinity Capture-Western physical 20027304 MAPK8 Biochemical Activity physical 20027304 ZBTB7A Affinity Capture-Western physical 19244234 HSF1 Affinity Capture-Western physical 19229036 SUV39H1 Affinity Capture-Western physical 19218236 KAT2B Biochemical Activity physical 19188449 KAT2B Affinity Capture-Western physical 19188449 E2F1 Affinity Capture-Western physical 19188449 KAT2B Affinity Capture-Western physical 19188449 NUDT21 Affinity Capture-Western physical 17172643 PAPOLA Affinity Capture-Western physical 17172643 KAT5 Affinity Capture-Western physical 19895790 KAT5 Affinity Capture-Western physical 19895790 PPARGC1A Co-localization physical 19553684 MEF2C Co-localization physical 19553684 MYOD1 Co-localization physical 19553684 RELA Affinity Capture-Western physical 17041012 CTTN Affinity Capture-Western physical 18850005 CTTN Reconstituted Complex physical 18850005 CTTN Biochemical Activity physical 18850005 C11orf17 Affinity Capture-Western physical 16998474 NEDD8 Affinity Capture-Western physical 16998474 AR Affinity Capture-Western physical 16923962 AR Affinity Capture-Western physical 16923962 AR Reconstituted Complex physical 16923962 AR Biochemical Activity physical 16923962 NCOR1 Reconstituted Complex physical 18829436 NCOR1 Affinity Capture-Western physical 18829436 JUN Affinity Capture-Western physical 18823944 DOT1L Affinity Capture-Western physical 19491102 CLOCK Affinity Capture-Western physical 18662547 ARNTL Affinity Capture-Western physical 18662547 CLOCK Reconstituted Complex physical 18662547 ARNTL Biochemical Activity physical 18662547 HDAC4 Affinity Capture-Western physical 16166628 FOXO1 Affinity Capture-Western physical 16154098 RRP8 Affinity Capture-Western physical 18485871 EZH2 Affinity Capture-Western physical 15684044 EZH2 Affinity Capture-Western physical 15684044 SUZ12 Affinity Capture-Western physical 15684044 BCL11A Affinity Capture-Western physical 15639232 BCL11A Reconstituted Complex physical 15639232 DBC1 Affinity Capture-Western physical 18235502 DBC1 Reconstituted Complex physical 18235502 TP53 Affinity Capture-Western physical 18235502 SIRT2 Affinity Capture-Western physical 18193082 RBP1 Affinity Capture-Western physical 18193082 ARID4B Affinity Capture-Western physical 18193082 ING2 Affinity Capture-Western physical 18193082 ING1 Affinity Capture-Western physical 18193082 FOXO4 Affinity Capture-Western physical 15126506 FOXO3 Affinity Capture-Western physical 15126506 FOXO3 Affinity Capture-Western physical 15126506 SUV39H1 Affinity Capture-Western physical 18004385 BHLHE41 Reconstituted Complex physical 17487425 TLE1 Two-hybrid physical 17680780 TLE1 Affinity Capture-Western physical 17680780 ESRRA Reconstituted Complex physical 20484414 ESRRA Biochemical Activity physical 20484414 NBN Affinity Capture-Western physical 17612497 NBN Reconstituted Complex physical 17612497 NBN Biochemical Activity physical 17612497 HIC1 Affinity Capture-Western physical 17283066 DVL1 Affinity Capture-Western physical 20439735 DVL2 Affinity Capture-Western physical 20439735 DVL2 Affinity Capture-Western physical 20439735 CSNK2A1 Affinity Capture-Western physical 20439735 CTNNB1 Affinity Capture-Western physical 20439735 MLLT3 Affinity Capture-MS physical 20431927 MLLT1 Affinity Capture-MS physical 20431927 NPM1 Affinity Capture-MS physical 20431927 DOT1L Affinity Capture-Western physical 20431927 NR0B2 Reconstituted Complex physical 20375098 NR0B2 Affinity Capture-Western physical 20375098 NR0B2 Affinity Capture-Western physical 20375098 HNF4A Affinity Capture-Western physical 20375098 SETD7 Affinity Capture-Western physical 21245319 SETD7 Affinity Capture-Western physical 21245319 SETD7 Reconstituted Complex physical 21245319 TP53 Affinity Capture-Western physical 21245319 STK4 Biochemical Activity physical 21212262 SMAD7 Affinity Capture-Western physical 17098745 SMAD7 Affinity Capture-Western physical 17098745 SMAD7 Reconstituted Complex physical 17098745 MAPT Reconstituted Complex physical 20869593 MAPT Affinity Capture-Western physical 20869593 NR1H4 Reconstituted Complex physical 19883617 NR1H4 Biochemical Activity physical 19883617 VDR Affinity Capture-Western physical 20733005 FOXO3 Affinity Capture-Western physical 20733005 FOXO3 Affinity Capture-Western physical 20733005 VDR Reconstituted Complex physical 20733005 SREBF1 Biochemical Activity physical 20595232 HNF1A Reconstituted Complex physical 21176092 HNF1A Affinity Capture-Western physical 21176092 HNF1A Affinity Capture-Western physical 21176092 SKI Affinity Capture-Western physical 21149449 TP53 Affinity Capture-Western physical 21149449 DBC1 Affinity Capture-Western physical 21030595 GAPDH Affinity Capture-Western physical 20972425 GAPDH Reconstituted Complex physical 20972425 ACACA Affinity Capture-Western physical 19343720 HSPA4 Affinity Capture-Western physical 19343720 WRN Affinity Capture-Western physical 19343720 ACACA Affinity Capture-MS physical 19343720 HSPD1 Affinity Capture-MS physical 19343720 CHCHD2 Affinity Capture-MS physical 19343720 DIAPH3 Affinity Capture-MS physical 19343720 YBX1 Affinity Capture-MS physical 19343720 DYNC1H1 Affinity Capture-MS physical 19343720 HSPA1L Affinity Capture-MS physical 19343720 HSPA5 Affinity Capture-MS physical 19343720 HIST1H2BC Affinity Capture-MS physical 19343720 HIST2H2AB Affinity Capture-MS physical 19343720 HSPA9 Affinity Capture-MS physical 19343720 HDAC2 Affinity Capture-MS physical 19343720 CMYA5 Affinity Capture-MS physical 19343720 KPNA2 Affinity Capture-MS physical 19343720 KPNA3 Affinity Capture-MS physical 19343720 LAMA3 Affinity Capture-MS physical 19343720 EEF1G Affinity Capture-MS physical 19343720 ARHGAP29 Affinity Capture-MS physical 19343720 MCF2L2 Affinity Capture-MS physical 19343720 ELL3 Affinity Capture-MS physical 19343720 USP9Y Affinity Capture-MS physical 19343720 NAT10 Affinity Capture-MS physical 19343720 UGDH Affinity Capture-MS physical 19343720 CACNA1C Affinity Capture-MS physical 19343720 WRN Affinity Capture-MS physical 19343720 LANCL1 Affinity Capture-MS physical 19343720 ATG7 Affinity Capture-Western physical 18296641 ATG5 Affinity Capture-Western physical 18296641 GABARAPL1 Affinity Capture-Western physical 18296641